Seroprevalence of Neutralizing Antibodies Against Japanese Encephalitis Virus Among 6 Years Old Children With 5 Different Immunization Strategies in Zhejiang Province
Japanese Encephalitis, Vaccine Preventable Disease, Vaccine Reaction
About this trial
This is an interventional prevention trial for Japanese Encephalitis focused on measuring Japanese Encephalitis, Seroprevalence, Immunogenicity, Immunization schedule, Safety
Eligibility Criteria
Inclusion Criteria:
- Participants aged ≥ 72 months to < 75 months.
- Participants have completed routine immunization schedules in time.
- Participants are healthy native residents.
- Parents/guardians can understand the protocol requirements, provide informed consent, accept all scheduled visits, and comply with all trial procedures.
Exclusion Criteria:
- History of neurological diseases or related symptoms.
- An acute illness with fever (temperature ≥ 37.1℃) or any acute onset of chronic diseases.
- Known impairment of immunologic function, or receipt of immunosuppressive therapy or immunoglobulin in the past 3 months.
- Known allergy to any constituent of the vaccine.
- Have been injected with other vaccines or any clinical trial drugs in the past 4 weeks.
- Any condition which, in the opinion of the investigator, would pose a health risk to the subject or interfere with the vaccine.
Sites / Locations
- Liandu center for disease control and prevention
- Kecheng center for disease control and prevention
- Pingyang center for disease control and prevention
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Experimental
Experimental
Experimental
Experimental
Experimental
3JEV-I (Group 1)
JEV-L+JEV-I (Group 2)
JEV-L+2JEV-I (Group 3)
2JEV-I+JEV-L (Group 4)
2JEV-L (Group 5)
Retrospective: 3 doses of JE vaccines. 2 doses of Inactivated JE Vaccine (JEV-I, 7-10 days apart) at 8 months of age and 1 dose of JEV-I at 2 years old. Prospective: 1 booster dose of JEV-I at 6 years old.
Retrospective: 2 doses of JE vaccines. 1 dose of JE attenuated live vaccine (JEV-L) at 8 months of age and 1 dose of JEV-I at 2 years old. Prospective: 1 booster dose of JEV-I at 6 years old.
Retrospective: 3 doses of JE vaccines. 1 dose of JEV-L at 8 months of age and 2 dose (7-10 days apart) of JEV-I at 2 years old.
Retrospective: 3 doses of JE vaccines. 2 doses of JEV-I (7-10 days apart) at 8 months of age and 1 dose of JEV-L at 2 years old.
Retrospective: 2 doses of JE vaccines. 2 doses of JEV-L respectively administered at 8 months of age and 2 years old.