Application of Magnesium-rich Artificial Cerebrospinal Fluid in Subarachnoid Hemorrhage
Intracranial Hemorrhage
About this trial
This is an interventional treatment trial for Intracranial Hemorrhage focused on measuring Intracranial Hemorrhage, Artificial cerebrospinal fluid, Cerebrospinal fluid replacement, Subarachnoid Hemorrhage
Eligibility Criteria
Inclusion Criteria:
- Patient is between 18 and 80 years of old;
- Patients with ICH rupture into the ventricle in the primary basal ganglia region or non-aneurysmal subarachnoid hemorrhage confirmed by skull imaging examination;
- Patient is admitted to hospital within 72 hours after onset;
- Informed consent of the patients or their family members, and signed informed consent for CSF replacement treatment.
Exclusion Criteria:
- Non-spontaneous intracranial hemorrhage;
- Time from onset to admission is longer than 72 hours;
- The patient who needs surgical treatment;
- Contraindication of lumbar puncture, such as: cerebral hernia, severe intracranial hypertension, puncture site inflammation, blood system diseases, etc.;
- Patient has other serious diseases, such as heart failure, kidney failure, liver failure, etc;
- Patient or his/her relatives refuse to accept the above research plan.
Sites / Locations
- First Affiliated Hospital of Xi'an Jiaotong UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
MACSF group
NS group
In the experimental group, patients with intracerebral hemorrhage ruptured into the ventricle and patients with subarachnoid hemorrhage were included in the stratified random method. Use Magnesium-Rich Artificial Cerebrospinal Fluid(MACSF) in the CSF replacement, and the remaining treatments should strictly follow the guidelines as same as the control group. The total amount of replacement was generally 30ml, and the replacement was performed once every 3 days. When the RBC count in CSF is less than 100×10^6/L, the CSF is considered to be cleared. Cerebrospinal fluid replacement is performed up to four times.
In the control group, patients with intracerebral hemorrhage ruptured into the ventricle and patients with subarachnoid hemorrhage were included according to the stratified random method. Use the normal saline (0.9% Sodium Chloride Injection) in the CSF replacement, and the remaining treatments should strictly follow the guidelines. The total amount of replacement was generally 30ml, and the replacement was performed once every 3 days. When the RBC count in CSF is less than 100×10^6/L, the CSF is considered to be cleared. Cerebrospinal fluid replacement is performed up to four times.