Infectious Diseases in Aged Population (AEQUI)
Respiratory Infections in Old Age, Bacteremia
About this trial
This is an interventional other trial for Respiratory Infections in Old Age focused on measuring functional dependency, quality of life, elderly people, respiratory infection, bacteraemia, disability
Eligibility Criteria
Inclusion Criteria For Case:
- Hospitalized adults 65 years or older,
- Presenting with bacteremia with positive blood culture (excluding catheter related infections) and/or
- WHO Severe Acute Respiratory Infection (SARI) case definition
- Upper respiratory infection = SARI (fever or history of fever >38°C, cough, onset of the disease within the last 10 days and requires hospitalisation)
- Lower respiratory infection = SARI with confirmed CT/CHR
- Informed consent form signed
- Patient affiliated to social security insurance
Exclusion Criteria For Case:
- Bedridden or terminally ill patient (based upon a threshold of ADL: ≤2 TBD, or CLINICAL FRAILTY SCALE: ≥8 )
- Patients that refuse the 3- and 6-months follow-up phone call assessments
- Patients that will not be able to answer the 3- and 6-months follow-up phone call assessments via a nurse
- Subject in exclusion period for another study,
- Subject who cannot be contacted in an emergency
- Persons referred to in Articles L1121-5 to L1121-8 of the French code of public health (this corresponds to all persons protected: pregnant or parturient women, breastfeeding mothers, persons deprived of liberty by judicial or administrative decision, persons subject to a legal protection measure).
Inclusion Criteria For Controls
- Same age (+/- 3 years)
- same sex,
- without suspicion of infection
- Hospitalized during the past or upcoming month in the same centre.
- Informed consent form signed
- Patient affiliated to social security insurance
Exclusion Criteria For Controls
- Bedridden or terminally ill patient (based upon a threshold of ADL: ≤2 TBD, or CLINICAL FRAILTY SCALE: ≥8 )
- Patients that refuse the 3- and 6-months follow-up phone call assessments
- Patients that will not be able to answer the 3- and 6-months follow-up phone call assessments via a nurse
- Subject in exclusion period for another study,
- Subject who cannot be contacted in an emergency
- Persons referred to in Articles L1121-5 to L1121-8 of the French code of public health (this corresponds to all persons protected: pregnant or parturient women, breastfeeding mothers, persons deprived of liberty by judicial or administrative decision, persons subject to a legal protection measure)
Sites / Locations
- University Hospital AmiensRecruiting
- Hospital ChamberyRecruiting
- Groupe Hospitalier Sud Ile de France
- Groupement Hospitalier portes de Provence
- Centre Hospitalier Intercommunal de Villeneuve St Georges.
- University Hospital PoitiersRecruiting
- CHRU Tours
- Policlinico Universitario BariRecruiting
- Unità Operativa Complessa di Geriatria-Camposampiero-ULSS 6Recruiting
- S.O.C. Geriatria-CatanzaroRecruiting
- Ospedale Civile di Dolo- ULSS 3 "Serenissima"Recruiting
- Ente Ospedaliero GallieraRecruiting
- Unità Operativa Complessa di Geriatria-Legnago-ULSS 9Recruiting
- S.C. Geriatria MonzaRecruiting
- Azienda Ospedaliera Universitaria Policlinico di PalermoRecruiting
- Istituto di Geriatria e Gerontologia-Azienda Ospedaliera di PerugiaRecruiting
- UOC Geriatria di RovigoRecruiting
- Malattie infettive - SanremoRecruiting
- FCRB - Fundació Clínic per a la Recerca BiomèdicaRecruiting
- FIBio-HCSC - Fundación para la Investigación Biomédica del Hospital Clínico San CarlosRecruiting
- FIBio-HRYC - Fundación para la Investigación Biomédica del Hospital Universitario Ramón y CajalRecruiting
- Instituto Murciano de Investigación Biosanitaria Virgen de la ArrixacaRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Bacteremia and/or acute respiratory infection
Without suspicion of infection
Hospitalized in a study center (emergency department, infectious disease, internal medicine or geriatric hospital wards…) for with bacteraemia and/or acute respiratory infection
The control patient will undergo the exact same procedures as the case patient described before except for the blood and respiratory sample part. • The typical control patient will be of the same age (+/- 3 years, but aged above 65 years), same sex, without suspicion of infection and hospitalized during the past or upcoming month in the same centre. There will be 2 controls for one case.