ICG-PDT, Periimplantitis, Diabetes Mellitus
Peri-Implantitis
About this trial
This is an interventional treatment trial for Peri-Implantitis focused on measuring photodynamic therapy*, periimplantitis*, diabetes mellitus*, indocyanine green*, photosensitizer*
Eligibility Criteria
Inclusion Criteria:
- adult patients above 45 years of age having type 2 DM
- HbA1c (≥6.5%) and fasting glucose test
- probing depth ≥6 mm with bleeding and/or suppuration on at least one site around dental implants that remained in situ
- On radiographic assessment, the implants exhibited ≥ 3 mm alveolar bone loss apical to the coronal region of the intraosteal portion of the dental implant.
- Exclusion Criteria Patients were excluded if they indicated current or former history of tobacco smoking, any systemic disease other than DM, enrolled in a non-surgical periodontal maintenance program, history of implant repair, pregnancy, and part six months use of antimicrobials, non-steroidal anti-inflammatory drugs, bisphosphonates, or corticosteroids.
Sites / Locations
- King Saud University
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Indocyanine green mediated photodynamic therapy (ICG-PDT)
Peri-implant mechanical debridement
Delivery of ICG solution at a concentration of 1 mg/mL will be used. The photosensitizer will be applied until the bottom of the peri-implant pocket using a 1 ml syringe. An 810 nm diode laser (A.R.C. laser GmbH, Nurnberg, Germany) with a power of 200 mW (continuous mode) and total energy of 4 J will be used to excite the ICG by starting from the papilla for 30 s followed by the insertion inside the peri-implant pocket depth for 10 s from both buccal and lingual side moving to coronal direction.
Non-surgical peri-implant mechanical debridement (PIMD) through ultrasonic device with a carbon tip.