Efficacy of Topical Antioxidants in Tretment of Photoaging
Photoaging
About this trial
This is an interventional treatment trial for Photoaging focused on measuring topical antioxidants, photoaged skin
Eligibility Criteria
Inclusion Criteria:
- Adult volunteers < 50 years old
- Clinical and dermoscopic features of photoaging.
Exclusion Criteria:
- Genodermatoses associated with photosensitivity.
- Treatment by medications affecting skin aging (eg, topical and systemic retinoids) in the last 6 months prior to enrollment.
- Any recent cosmetic procedures.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Placebo Comparator
Group 1(treatment group)
Group 2 (positive control)
Group 3 (Negative control)
Topical application of a cream of a combination of antioxidants once daily at night for 6 months Name: Selenium ACE cream (Interpharma UK company, Egypt) Ingredients: Selenium (Selenium amino acid chelate) 0.5% Vitamin C (Sodium ascorbyl phosphate - stay C) %1 Vitamin E (Tocopheryl acetate) % 0.5 Vitamin A (Retinyl palmitate) %1 Emulsifiers ( Ceteareth 20 , Glycerol monostearate , Cetyl alcohol) Emollient(Caprylic capric triglycerides)
Topical application of a retinoid (tretinoin 0.05%) cream once daily at night for 6 months (Acretin 0.05% cream Jamjoom pharmaceuticals, Egypt)
Topical application of a panthenol cream once daily at night for 6 months (panthenol 2% cream, El Nile company, Egypt)