CARotid Mri of Atherosclerosis (CARMA)
Carotid Stenosis, Carotid Artery Plaque, Carotid Atherosclerosis
About this trial
This is an interventional prevention trial for Carotid Stenosis focused on measuring Carotid stenosis, Cardiovascular MRI, Atherosclerotic plaque
Eligibility Criteria
Inclusion Criteria:
- Carotid plaques with a cut-off at doppler flow velocity ≥ 1.3 m/sec at a Doppler angle of 50-60°, which corresponds to a ≥ 50% stenosis according to these criteria.
Exclusion Criteria:
- Performed or planned carotid surgery
- Carotid occlusion
- Renal failure (GFR <45 ml/h)
- Inflammatory diseases, anti-inflammatory treatment or malignancies
- Stroke <30 days before admission
- Co-morbidities that disable informed consent or participation in the study investigations (e.g. contraindications for MRI)
Sites / Locations
Arms of the Study
Arm 1
Experimental
CARMA study participants
All patients in the study are in the same treatment arm: all were treated for 12 months according to routine care and international guidelines for cardiovascular disease prevention in patients with very high cardiovascular risk. Through study physicians patients received an individual assessment and optimized cardiovascular risk management, including life style advice and adjustments in their medical preventive treatment, based on drugs used in standard care (eg. lipid lowering medication, anti-hypertensive-treatment, anti-thrombotic treatment). All treatment goals were set in accordance with current guidelines at the time for study participation.