Blood Flow Regulation in Individuals With Down Syndrome - Training Study
Down Syndrome
About this trial
This is an interventional supportive care trial for Down Syndrome focused on measuring exercise, blood flow regulation, blood pressure, heart rate
Eligibility Criteria
Inclusion Criteria:
- generally healthy
- sedentary (defined as being involved in less than 30 minutes of moderately-intense physical activity per day)
- additionally for the participants with Down syndrome:
- diagnosis of Down syndrome trisomy 21 and
- normal thyroid function or stable thyroid function (and medications) for at least 6 mo.
Exclusion Criteria:
- congenital heart disease;
- atherosclerotic or other vascular disease;
- asthma or other pulmonary disease;
- hypertension (defined BP >140/90 mmHg);
- blood pressure below 90/60 mmHg;
- history of pre-syncope or syncope;
- diabetes (defined as Hba1c of >7.5% or use of glucose lowering medication);
- severe obesity (defined as BMI >40);
- medications affecting heart rate, blood pressure or arterial function;
- anti-inflammatory medication including NSAIDS;
- current smoking and
- pregnancy.
Sites / Locations
- University of Nevada, Las VegasRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Sham Comparator
No Intervention
Combined exercise intervention Down syndrome
Usual care Down Syndrome
Reference group without Down syndrome
The exercise intervention will last 12 weeks and will consist of a supervised combined aerobic and resistance training program with a frequency of 3 days/week.In the exercise sessions, the participant will work with the trainer on their strength, balance and aerobic endurance. Each session consists of 10 min of strength exercises (Foundational Exercise), 10 min of Hip Strengthening, 10 min of Vestibular and Balance Exercise, and 20 min of Aerobic Exercise, and starts with a warming up and ends with stretching/cooling down. Each new exercise will be introduced in easy steps and practiced until the participant is comfortable executing it.
The control condition consists of usual activities.
This reference group of age- and sex-matched inactive individuals without Down syndrome will undergo the same baseline testing as the other groups but without intervention or post-intervention measures.