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Deep Brain Stimulation in Alzheimer's Disease: Biomarkers and Dose Optimization

Primary Purpose

Alzheimer Disease

Status
Active
Phase
Not Applicable
Locations
Canada
Study Type
Interventional
Intervention
Deep Brain Stimulation
Sponsored by
University Health Network, Toronto
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Alzheimer Disease focused on measuring Deep Brain Stimulation, Biomarkers, Memory, Beta Amyloid, Limbic System, Fornix, Tau

Eligibility Criteria

45 Years - 85 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  1. Informed consent signed by the subject AND a reliable caregiver
  2. 45-85 years of age (inclusive)
  3. Probable Alzheimer's disease according to the National Institute of Aging Alzheimer's disease Association criteria.
  4. Clinical Dementia Rating (CDR) global rating of 0.5 or 1 at screening.
  5. ADAS-cog-11 score of 12-30 inclusive at screening AND baseline (with a score ≥ 4 on ADAS-cog item 1) or a Mini Mental State Examination (MMSE) of 16-28.
  6. If female, post-menopausal, surgically sterile or willing to use birth control methods for the duration of the study.
  7. The patient has an available caregiver or other appropriate knowledgeable informant who can reliably report on daily activities and function and signs the informed consent for participation as such.
  8. Patient is living at home and likely to remain at home for the study duration.
  9. General Medical Health Rating (GMHR) ≥ 3 (good or excellent general health).
  10. Patient must be a good surgical candidate for placement of a deep brain stimulator as judged by the DBS surgical team.
  11. Fluency (oral and written) in the language in which standardized tests will be administered.
  12. The patient is taking a stable dose of cholinesterase inhibitor (AChEI) medication (donepezil, galantamine, or rivastigmine) for at least 60 days prior to signing the informed consent form and there is no intention to modify the dose over the course of the study (NOTE: These medications may NOT be initiated, discontinued or modified after study initiation for the length of study participation).

Exclusion Criteria:

  1. Neuropsychiatric Inventory (NPI) total score ≥ 10 or score ≥ 4 in any NPI domain (clinically significant neuropsychiatric symptoms). Apathy score ≥ 4 acceptable.
  2. Subjects at risk for suicide in the opinion of the investigator or the subject answers "yes" to "Suicidal Ideation" Item 4 or 5 on the C-SSRS (at time of evaluation) at the screening or baseline visit.
  3. Cornell Scale for Depression and Dementia (CSDD) score > 10 at the screening visit
  4. Young Mania Rating Scale (YMRS) ≥ 11 at the screening visit
  5. Current major psychiatric disorder such as schizophrenia, bipolar disorder or major depressive disorder based on psychiatric consult at screening visit
  6. The subject has attempted suicide in the 2 years prior to signing the consent to participate in the study.
  7. In the judgment of the investigator, the subject is at significant risk for suicidal behavior during the course of his/her participation in the study
  8. History of head trauma in the 2 years prior to signing the consent to participate in the study
  9. History of brain tumor, subdural hematoma, or other clinically significant (in the judgment of the investigator) space-occupying lesion on CT or MRI
  10. Active psychiatric disorder
  11. Mental retardation
  12. Current alcohol or substance abuse as defined by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR)
  13. Contraindications for PET scanning (e.g., insulin dependent diabetes)
  14. Contraindications for MRI scanning, including implanted metallic devices (e.g. non-MRI-safe cardiac pacemaker or neurostimulator; some artificial joints metal pins; surgical clips; or other implanted metal parts), or claustrophobia or discomfort in confined spaces.
  15. Radiation exposure in the 1 year prior to signing the informed consent form that, in combination with the radiation exposure from this study, would exceed 5 rem.
  16. Abnormal lab results that, in the opinion of the investigator and/or enrollment review committee, would preclude participation in the study.
  17. Abnormal cardiovascular or neurovascular disorder that, in the opinion of the investigator and/or enrollment review committee, would preclude participation in the study.
  18. Unstable dose of any medication prescribed for the treatment of memory loss or Alzheimer's disease.
  19. Currently prescribed any non-AD medications that, in the opinion of the investigator and/or enrollment review committee, would preclude participation in the study.
  20. Is unable or unwilling to comply with protocol follow-up requirements.
  21. Has a life expectancy of < 1 year.
  22. Is actively enrolled in another concurrent clinical trial.

Sites / Locations

  • Toronto Western Hospital, University Health Network

Arms of the Study

Arm 1

Arm Type

Experimental

Arm Label

Treatment

Arm Description

All patients will be implanted with a deep brain stimulation system and will receive personalized fornix stimulation; parameters will be selected based on the dose finding cognitive tests.

Outcomes

Primary Outcome Measures

Change in Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog)
Cognitive abilities
Change in Clinical Dementia Rating (CDR) Scale
Dementia staging, Minimum score of 0 (better) and Maximum score of 3 (worse)
Change in PET scan
Levels of amyloid beta in brain
Change in Cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease
Levels of amyloid beta, tau proteins in CSF
Change in MRI scan
Volumes of specified brain areas

Secondary Outcome Measures

Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory 23-item Scale (ADCS-ADL23)
Ability to perform basic and instrumental daily activities, Minimum score of 0 (worse) and Maximum score of 78 (better)
Hopkins Verbal Learning Test (HVLT)
Memory for words
Visual Association Memory Test
Memory for visual stimuli

Full Information

First Posted
April 16, 2021
Last Updated
May 16, 2022
Sponsor
University Health Network, Toronto
Collaborators
Johns Hopkins University
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1. Study Identification

Unique Protocol Identification Number
NCT04856072
Brief Title
Deep Brain Stimulation in Alzheimer's Disease: Biomarkers and Dose Optimization
Official Title
Deep Brain Stimulation of the Fornix in Alzheimer's Disease: Investigations Into Clinical and Imaging Biomarkers and Dose Optimization
Study Type
Interventional

2. Study Status

Record Verification Date
May 2022
Overall Recruitment Status
Active, not recruiting
Study Start Date
December 19, 2014 (Actual)
Primary Completion Date
December 2023 (Anticipated)
Study Completion Date
December 2023 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University Health Network, Toronto
Collaborators
Johns Hopkins University

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
Yes
Product Manufactured in and Exported from the U.S.
Yes

5. Study Description

Brief Summary
Title: Deep Brain Stimulation of the Fornix in Alzheimer's Disease: Investigating clinical and imaging biomarkers and dose optimization Objective: To evaluate the influence of deep brain stimulation in Alzheimer's Disease (AD)on markers of AD pathology in cerebrospinal fluid (CSF) and on neuroimaging with positron emission tomography (PET) and to optimize electrical stimulation parameters. Population size: Twelve (12) patients will be recruited and enrolled in this study. Study design: This is a prospective, open-label trial designed to study the effect of brain stimulation on CSF and brain amyloid pathology in AD. In addition, patients will undergo neuropsychological testing at various stimulation settings to help determine optimal stimulation parameters. Study duration: Patients will complete screening and baseline assessments before undergoing DBS implantation surgery, after which they will be followed-up for 12 months.
Detailed Description
Background/Rationale: Despite years of recognition and attempts at treatment, Alzheimer's Disease (AD) remains a pervasive and challenging condition, with an inexorable progression to severe disability and death once a diagnosis is made. The latest attempts at pharmacologic have yielded, at best, very modest results. There exists, therefore, no treatment for AD that significantly slows down its progression, and alters the metabolic milieu of AD brains. We have conducted and published the world's first phase I safety and feasibility trial of deep brain stimulation (DBS) for early Alzheimer's Disease and the first Phase II randomized, placebo-controlled study of DBS in the same population. These trials have had the following three objectives: 1) establishing the safety of DBS in AD, 2) studying the possible slowing of cognitive decline in AD, and 3) studying the relationship between focal brain stimulation and metabolic changes in regions known to be affected by AD neurodegeneration. With this background, we now want to continue and expand our DBS for AD trials. The rationale of the currently proposed study is to optimize patient selection and stimulation parameter dose for DBS for AD. We will measure the effects of DBS on brain amyloid load, on cerebrospinal fluid (CSF) Alzheimer protein metabolites and will screen various stimulation parameter settings for their acute effects on memory function. The latter will be used in an attempt to define the optimal stimulation dose. The significance of this study is two-fold: 1) A possible demonstration that DBS may directly influence brain pathology in AD as measured by amyloid imaging and CSF protein changes, hence providing a mechanism of action for its clinical effects, and 2) the first study to empirically determine, using a memory task, the optimal stimulation parameters for DBS patients to improve memory function. Study Objectives: Influence of DBS on AD Pathology Early results suggest that DBS may influence cognitive and memory functions in patients with early Alzheimer's Disease (AD). It is not clear, however, whether DBS can directly influence pathology in AD, such as CSF protein biomarkers and amyloid plaque load in the brain. The objective of this study is to analyze CSF and brain plaque load prior to and after surgery to determine whether DBS influences central nervous systems pathology associated with AD. Dose Optimization Currently, selecting the optimal stimulation dose for patients with non-motor conditions (i.e. Alzheimer's Disease, depression, obsessive-compulsive disorder) is performed largely arbitrarily, and borrows heavily from settings used in motor conditions (i.e. Parkinson's Disease, Tremor). The objective of this study is to establish a clinically meaningful dose optimization test that will use the patients' performance on an experimental memory task to determine the optimal stimulation settings. Study Hypotheses: Our study has the following exploratory hypotheses: i. DBS may lead to changes in CSF biomarkers of AD pathology, including tau, phosphorylated tau, and beta amyloid, consistent with plaque clearance ii. DBS may lead to reductions in plaque burden, demonstrated by amyloid PET imaging iii. The optimal dose of brain stimulation, which maximizes benefits and minimizes adverse events, can be selected using an acute memory task performed in the post-operative period. Design and Methodology: This is an open-label, prospective trial designed to measure the influence of DBS on AD brain pathology and to optimize stimulation parameter selection post-operatively. Twelve (12) patients will be enrolled and operated, and followed in an open-label fashion. All subjects will be followed to a common closing date, which will be at the time the last subject enrolled is followed for 12 months. Patient selection and enrollment: Pre-treatment procedures The schedule for individual subjects is outlined below in table format and is displayed in Figure 1 as a flowchart. This study is divided into four phases: screening, baseline, surgery, and on-stimulation. All patients will be recruited through the memory clinic at Toronto Western Hospital and local advertisements. Patients meeting inclusion/exclusion criteria will be approached for participation. There will be two distinct periods of informed consent in this study: the first, to allow study investigators to screen patients for study inclusion, and the second, to formally enroll patients into the study. Figure 1 outlines the process that will take place for identified patients and the estimated number of individual subjects at each stage. Once patients are identified by the study neurologist, screening consent will be obtained. This consent will signal entrance into the first phase of the study, and indicates that the patient meets inclusion/exclusion criteria. During the screening visit, patients will undergo a medical history and general physical examination, medication screening, electrocardiogram, relevant pre-operative blood work, neuropsychological testing and psychiatric screening: the Alzheimer's Disease Assessment Scale-Cognitive Subscale(ADAS-Cog) Clinical Dementia Rating (CDR) scale, Neuropsychiatric Inventory (NPI), Columbia Suicide Severity Rating Scale (C-SSRS), Cornell Scale for Depression in Dementia (CSDD), Young Mania Rating Scale (YMRS), which will be used to classify participants by inclusion/exclusion criteria. Once the screening is complete, patients will be discussed by the study team to determine whether they should continue in the trial, and progress to the baseline stage. The baseline stage will require an additional informed consent, as this stage signals entry into the formal trial. Baseline investigations will commence within 2 months of signing baseline consent, and can take place up to within 1 day of surgery ("implantation"). Baseline investigations will include all tests and examinations done during Screening (excepting the ECG), with the addition of: the Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory 23-item Scale (ADCS-ADL23), the Hopkins Verbal Learning Test (HVLT), neuroimaging (MRI and Amyloid PET) as well as a lumbar puncture (LP) for AD protein markers. Participants will also complete acute experimental memory tasks that will be used in the 'dosing' phase, to familiarize them with the procedure. For these memory tasks, patients will view stimuli (e.g., objects, faces, scenes, words), and then be asked to remember them. In addition, an experimental visual associative recognition task, which is a simplified version of the one that was critical in identifying memory-specific effects in the sentinel case (Hamani et al 2008), will be introduced at this stage. Once all baseline investigations are complete, patients will be scheduled for surgery and implantation. Treatment procedures - DBS surgery DBS surgery will be performed as is done routinely and has been performed on the previous 18 patients with AD at our centre. Patients will arrive on the morning of surgery at the Toronto Western Hospital medical imaging department. They will have a small part of their head shaved and then have a stereotactic frame attached directly to their skull, after infiltration with local anaesthesia. The frame allows precise co-ordinates to be acquired so that deep brain structures can be targeted with implanted electrodes. The patient will then undergo an MRI scan (for surgical planning) with the frame in place, followed by transport directly to the operating room. The anaesthesia team will insert an intravenous line followed by induction and initiation of general anaesthesia (GA). The entire case, including electrode implantation and implantation of the pulse generator, will be done under general anaesthesia with the patient fully asleep. In the operating room the patient's head, via the frame, will be attached to the operating room table, and their scalp infiltrated with additional local anaesthetic. A skin incision will be made and two 2.5 mm diameter burr holes drilled through the skull. A DBS electrode will be delivered at the fornix target as identified on the MRI scan obtained earlier in the morning. The patient will be monitored throughout the entire case. Once implanted, the second stage of the operation with begin (about 30 min) whereby the electrodes are connected to a battery placed under the right collarbone. With the patient asleep, the electrodes are tunneled to the battery, and connected. Both the head and chest incisions are then closed and the patient transferred to the recovery room. Following surgery, the patient will be transferred to the neurosurgical ward for recovery. On the first post-op day, they will undergo an MRI of their brain to confirm the electrode location. Should the electrodes be in a suboptimal location (e.g. nearby but not within the target), patients will be offered several options: re-operation for lead repositioning, leave the system in place and turn device on, leave the system in place and keep device off, or removal of the system completely. Recovery following surgery should take 1-2 days, and patients will be discharged home on post-op day 2, with the stimulator in the off position. Patients will return to the neurosurgical clinic two weeks after discharge to check the wound, remove staples, and for routine post-op follow-up. Other Procedures Beta-Amyloid Positron Emission Tomography (PET) scans. Beta-Amyloid PET scans will be used to estimate amyloid burden in the brains of the patients and to probe whether DBS has an impact on this process. Flutemetamol (GE Healthcare) is an FDA-approved amyloid PET radiotracer that has been approved by Health Canada for research use. PET scans will be performed on a Siemens HRRT scanner. During radiotracer uptake, patients will be maintained in a quiet, dimly lit room, with eyes open and ears unoccluded. Ninety minutes after a 5mCi ± 10% radiotracer injection, patients will be positioned in the scanner, and a 20-minute emission scan will be obtained, followed by a transmission scan. Lumbar Puncture (LP) for protein analysis. The procedure is done with patients lying on their side. The skin is washed with sterilizing solution; 3 ml of local anesthetic is injected in the skin and subcutaneous tissue at the lumbar 4/5 level. 6 ml of CSF is removed and distributed in aliquots. The samples are immediately frozen and stored at -80C. CSF levels of Tau, phosphoTau and beta amyloid are determined by standard protein analysis. The analysis will be performed as per the Alzheimer's Disease Neuroimaging Initiative (ADNI) guidelines. Stimulation dose finding studies. At the patient visits, the DBS will be programmed to test the effects of various stimulus settings on memory performance. Testing sessions will last up to 2.5 hours or less if, the patient becomes tired. Settings will be adjusted to ensure that the patients do not feel or experience adverse effects. Heart rate will be monitored during programming. Patients will be asked to perform a memory task at each of the tested settings to determine optimal setting during subsequent visits. This setting will remain stable until the next visit, at which time settings will again be evaluated and may be changed. For the memory tasks, patients will view stimuli (e.g., objects, faces, scenes, words), and will then be asked to remember the stimuli. Each test will last approximately 5-10 minutes.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Alzheimer Disease
Keywords
Deep Brain Stimulation, Biomarkers, Memory, Beta Amyloid, Limbic System, Fornix, Tau

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Model Description
Group of 12 patients will be implanted with a deep brain stimulation system and followed up for a 12-month post-operative period.
Masking
None (Open Label)
Allocation
N/A
Enrollment
12 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Treatment
Arm Type
Experimental
Arm Description
All patients will be implanted with a deep brain stimulation system and will receive personalized fornix stimulation; parameters will be selected based on the dose finding cognitive tests.
Intervention Type
Device
Intervention Name(s)
Deep Brain Stimulation
Intervention Description
Personalized Deep Brain Stimulation of Fornix
Primary Outcome Measure Information:
Title
Change in Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog)
Description
Cognitive abilities
Time Frame
Screening, Baseline, Post-Operative Months 1, 3, 6, 9, 12
Title
Change in Clinical Dementia Rating (CDR) Scale
Description
Dementia staging, Minimum score of 0 (better) and Maximum score of 3 (worse)
Time Frame
Screening, Baseline, Post-Operative Months 3, 6, 9, 12
Title
Change in PET scan
Description
Levels of amyloid beta in brain
Time Frame
Baseline, Post-Operative Months 6, 12
Title
Change in Cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease
Description
Levels of amyloid beta, tau proteins in CSF
Time Frame
Baseline, Post-Operative Months 6, 12
Title
Change in MRI scan
Description
Volumes of specified brain areas
Time Frame
Baseline, Post-Operative Months 6, 12
Secondary Outcome Measure Information:
Title
Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory 23-item Scale (ADCS-ADL23)
Description
Ability to perform basic and instrumental daily activities, Minimum score of 0 (worse) and Maximum score of 78 (better)
Time Frame
Baseline, Post-Operative Months 3, 6, 9, 12
Title
Hopkins Verbal Learning Test (HVLT)
Description
Memory for words
Time Frame
Baseline, Post-Operative Months 3, 6, 9, 12
Title
Visual Association Memory Test
Description
Memory for visual stimuli
Time Frame
Baseline, Post-Operative Months 3, 6, 9, 12
Other Pre-specified Outcome Measures:
Title
Neuropsychiatric Inventory (NPI)
Description
Evaluates level of neuropsychiatric symptoms
Time Frame
Screening, Baseline, Post-Operative Months 3, 6, 9, 12
Title
Cornell Scale for Depression in Dementia (CSDD)
Description
Evaluates symptoms of major depressive disorder; qualitative (presence/absence of symptoms); Minimum score of 0 (better) and Maximum score of 2 (severe)
Time Frame
Screening, Baseline, Post-Operative Months 3, 6, 9, 12
Title
Columbia Suicide Severity Rating Scale (C-SSRS)
Description
This scale is intended to be used by individuals who have received training in its administration. The questions contained in the Columbia-Suicide Severity Rating Scale are suggested probes. Ultimately, the determination of the presence of suicidal ideation or behavior depends on the judgment of the individual administering the scale.
Time Frame
Screening, Baseline, Post-Operative Months 3, 6, 9, 12
Title
Young Mania Rating Scale (YMRS)
Description
Evaluates symptoms of mania. The scale contains 4 items rated from 0 to 8 points and 7 items rated from 0 to 4 points. Minimum score = 0 (better), maximum score = 60 (worse).
Time Frame
Screening, Baseline, Post-Operative Months 3, 6, 9, 12

10. Eligibility

Sex
All
Minimum Age & Unit of Time
45 Years
Maximum Age & Unit of Time
85 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Informed consent signed by the subject AND a reliable caregiver 45-85 years of age (inclusive) Probable Alzheimer's disease according to the National Institute of Aging Alzheimer's disease Association criteria. Clinical Dementia Rating (CDR) global rating of 0.5 or 1 at screening. ADAS-cog-11 score of 12-30 inclusive at screening AND baseline (with a score ≥ 4 on ADAS-cog item 1) or a Mini Mental State Examination (MMSE) of 16-28. If female, post-menopausal, surgically sterile or willing to use birth control methods for the duration of the study. The patient has an available caregiver or other appropriate knowledgeable informant who can reliably report on daily activities and function and signs the informed consent for participation as such. Patient is living at home and likely to remain at home for the study duration. General Medical Health Rating (GMHR) ≥ 3 (good or excellent general health). Patient must be a good surgical candidate for placement of a deep brain stimulator as judged by the DBS surgical team. Fluency (oral and written) in the language in which standardized tests will be administered. The patient is taking a stable dose of cholinesterase inhibitor (AChEI) medication (donepezil, galantamine, or rivastigmine) for at least 60 days prior to signing the informed consent form and there is no intention to modify the dose over the course of the study (NOTE: These medications may NOT be initiated, discontinued or modified after study initiation for the length of study participation). Exclusion Criteria: Neuropsychiatric Inventory (NPI) total score ≥ 10 or score ≥ 4 in any NPI domain (clinically significant neuropsychiatric symptoms). Apathy score ≥ 4 acceptable. Subjects at risk for suicide in the opinion of the investigator or the subject answers "yes" to "Suicidal Ideation" Item 4 or 5 on the C-SSRS (at time of evaluation) at the screening or baseline visit. Cornell Scale for Depression and Dementia (CSDD) score > 10 at the screening visit Young Mania Rating Scale (YMRS) ≥ 11 at the screening visit Current major psychiatric disorder such as schizophrenia, bipolar disorder or major depressive disorder based on psychiatric consult at screening visit The subject has attempted suicide in the 2 years prior to signing the consent to participate in the study. In the judgment of the investigator, the subject is at significant risk for suicidal behavior during the course of his/her participation in the study History of head trauma in the 2 years prior to signing the consent to participate in the study History of brain tumor, subdural hematoma, or other clinically significant (in the judgment of the investigator) space-occupying lesion on CT or MRI Active psychiatric disorder Mental retardation Current alcohol or substance abuse as defined by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) Contraindications for PET scanning (e.g., insulin dependent diabetes) Contraindications for MRI scanning, including implanted metallic devices (e.g. non-MRI-safe cardiac pacemaker or neurostimulator; some artificial joints metal pins; surgical clips; or other implanted metal parts), or claustrophobia or discomfort in confined spaces. Radiation exposure in the 1 year prior to signing the informed consent form that, in combination with the radiation exposure from this study, would exceed 5 rem. Abnormal lab results that, in the opinion of the investigator and/or enrollment review committee, would preclude participation in the study. Abnormal cardiovascular or neurovascular disorder that, in the opinion of the investigator and/or enrollment review committee, would preclude participation in the study. Unstable dose of any medication prescribed for the treatment of memory loss or Alzheimer's disease. Currently prescribed any non-AD medications that, in the opinion of the investigator and/or enrollment review committee, would preclude participation in the study. Is unable or unwilling to comply with protocol follow-up requirements. Has a life expectancy of < 1 year. Is actively enrolled in another concurrent clinical trial.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Andres Lozano, MD, PhD
Organizational Affiliation
University Health Network, Toronto
Official's Role
Principal Investigator
Facility Information:
Facility Name
Toronto Western Hospital, University Health Network
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5T 2S8
Country
Canada

12. IPD Sharing Statement

Plan to Share IPD
No
IPD Sharing Plan Description
As required for publication in a scientific journal.
Citations:
PubMed Identifier
20687206
Citation
Laxton AW, Tang-Wai DF, McAndrews MP, Zumsteg D, Wennberg R, Keren R, Wherrett J, Naglie G, Hamani C, Smith GS, Lozano AM. A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease. Ann Neurol. 2010 Oct;68(4):521-34. doi: 10.1002/ana.22089.
Results Reference
background
PubMed Identifier
27567810
Citation
Lozano AM, Fosdick L, Chakravarty MM, Leoutsakos JM, Munro C, Oh E, Drake KE, Lyman CH, Rosenberg PB, Anderson WS, Tang-Wai DF, Pendergrass JC, Salloway S, Asaad WF, Ponce FA, Burke A, Sabbagh M, Wolk DA, Baltuch G, Okun MS, Foote KD, McAndrews MP, Giacobbe P, Targum SD, Lyketsos CG, Smith GS. A Phase II Study of Fornix Deep Brain Stimulation in Mild Alzheimer's Disease. J Alzheimers Dis. 2016 Sep 6;54(2):777-87. doi: 10.3233/JAD-160017.
Results Reference
background
PubMed Identifier
18232017
Citation
Hamani C, McAndrews MP, Cohn M, Oh M, Zumsteg D, Shapiro CM, Wennberg RA, Lozano AM. Memory enhancement induced by hypothalamic/fornix deep brain stimulation. Ann Neurol. 2008 Jan;63(1):119-23. doi: 10.1002/ana.21295.
Results Reference
background

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Deep Brain Stimulation in Alzheimer's Disease: Biomarkers and Dose Optimization

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