Influence of Nocturnal Light Exposure on the Impairment of Glucose Tolerance Induced by Chronic Sleep Restriction
Glucose Intolerance, Sleep Deprivation, Sleep
About this trial
This is an interventional basic science trial for Glucose Intolerance focused on measuring Chronic Sleep Restiction, Artificial Light At Night, Glucose Intolerance, Melatonin, Sleep
Eligibility Criteria
Inclusion Criteria:
- Healthy adults with conventional and regular sleep-wake timing
- Non-smokers
- Completion of medical, psychological, and sleep screening tests
- Able to spend 33 consecutive days/nights in the laboratory
- Normal color vision
Exclusion Criteria:
- History of neurological or psychiatric disorder
- History of sleep disorder or regular use of sleep-promoting medication
- Current prescription, herbal, or over-the-counter medication use
- Traveling across 2 or more time zones within past 3 months
- Donating blood within past 8 weeks
- Worked night or rotating shift work within past 3 years
- Hearing impairment, visual impairment
- History of eye trauma or surgery
- Drug or alcohol dependency
Sites / Locations
- Brigham and Women's HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Sleep Restriction with Extended Duration Artificial Light at Night (ALAN)
Sleep Restriction without Extended Duration Artificial Light at Night (ALAN)
In the Sleep Restriction Group with Extended Duration Artificial Light At Night (ALAN) first, the sleep episodes will be shortened to 5 hours, centered at the same time as the baseline sleep (with bedtime 2.5 hours later and wake time 2.5 hours earlier).
In the Sleep Restriction group without Extended Duration ALAN, the sleep episodes will be shortened to 5 hours as in the ALAN Condition (centered at the same time as the baseline sleep with bedtime 2.5 hours later and wake time 2.5 hours earlier), but the participant will remain sitting in bed in near darkness (< 1 lux) for the 2.5 hours before and after the 5-hour sleep episode, such that their exposure to room lighting and activity (14 hours/day) will remain similar to that in the Baseline condition.