Back to resultsA Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy (Astefania)
Primary Purpose
Breast Cancer
Status
Recruiting
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Atezolizumab
Trastuzumab Emtansine
Placebo
Trastuzumab
Sponsored by
About this trial
This is an interventional treatment trial for Breast Cancer
Eligibility Criteria
Inclusion Criteria:
- Histologically confirmed invasive breast carcinoma
- Centrally-confirmed human epidermal growth factor receptor 2 (HER2)-positive invasive breast cancer
- Centrally confirmed PD-L1 and hormone receptor status
- Clinical stage at disease presentation: cT4/anyN/M0, any cT/N2-3/M0, or cT1-3/N0-1/M0 (participants with cT1mi/T1a/T1b/N0 are not eligible)
- Completion of pre-operative systemic chemotherapy including at least 9 weeks of taxane and 9 weeks of trastuzumab (anthracycline and/or additional HER2-targeted agents are permitted)
- <=12 weeks between primary surgery and randomization
- Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1
- Screening left ventricular ejection fraction (LVEF) >= 50% and no decrease in LVEF by >15% from the pre-chemotherapy LVEF. If no pre-chemotherapy LVEF, screening LVEF >= 55%
- Life expectancy >= 6 months
- Adequate hematologic and end organ function
Exclusion Criteria:
- Stage IV breast cancer
- An overall response of disease progression according to the investigator at the conclusion of preoperative systemic therapy
- Prior treatment with T-DM1, or atezolizumab, or other immune checkpoint inhibitors
- History of exposure to various cumulative doses of anthracyclines
- History of other malignancy within 5 years prior to screening, except for appropriately treated carcinoma in situ of the cervix, non-melanoma skin carcinoma, Stage I uterine cancer, or ductal carcinoma in situ (DCIS)
- Current grade >=2 peripheral neuropathy
- History of idiopathic pulmonary fibrosis, organizing pneumonia, or pneumonitis
- History of or active autoimmune disease or immune deficiency
- Treatment with immunostimulatory or immunosuppressive agents
- Cardiopulmonary dysfunction
- Any known active liver disease
Sites / Locations
- Alabama Oncology
- Roy and Patricia Disney Family Cancer Center- Providence Saint Joseph Medical CenterRecruiting
- Innovation Clinical Research InstituteRecruiting
- California Cancer Associate for Research & ExcellenceRecruiting
- Glendale Adventist Medical Ctr
- UCLA Medical Center
- Cancer Specialists; North Florida ;Jacksonville (AC Skinner Pkwy)Recruiting
- Florida Cancer SpecialistsRecruiting
- University Cancer & Blood Center, LLC; ResearchRecruiting
- Northwest Georgia Oncology Centers, a Service of Wellstar Cobb HospitalRecruiting
- Elmhurst Memorial Healthcare
- Edward Cancer Center Naperville
- Edward Cancer Center Plainfield
- University of IowaRecruiting
- Pontchartrain Cancer CenterRecruiting
- New England Cancer SpecialistsRecruiting
- University of Maryland Medical CenterRecruiting
- Mercy Medical CenterRecruiting
- Greater Baltimore Med Ctr; Dept Berman Cancer InstituteRecruiting
- Henry Ford Health System; Clinical Trials Office; Clinical Trials OfficeRecruiting
- Jackson Oncology Associates, PLLCRecruiting
- Central Care Cancer Center; NCRecruiting
- MD Anderson Cancer Center at Cooper
- Jersey Shore University Medical Centre
- The Valley HospitalRecruiting
- Mount Sinai Medical Center
- Great Lakes Cancer Center
- Messino Cancer Centers
- Levine Cancer InstituteRecruiting
- Providence Health & Services - Oregon
- Bryn Mawr HospitalRecruiting
- Abramson Cancer Center; Univ of Pennsylvania; Clinical Research UnitRecruiting
- Lankenau HospitalRecruiting
- Roper St. Francis HealthcareRecruiting
- Avera Cancer Institute
- SCRI Tennessee Oncology Chattanooga
- The West Clinic; West Cancer Center
- Thompson Cancer Survival CenterRecruiting
- Tennessee Oncology; Sarah Cannon Research Institute
- Joe Arrington Cancer Research & Treatment CenterRecruiting
- Mays Cancer Center at UT Health San Antonio MD Anderson CancerRecruiting
- Hematology Oncology Associates of Fredericksburg, Inc.Recruiting
- Virginia Oncology Associates - New Port NewsRecruiting
- Virginia Oncology AssociatesRecruiting
- Virginia Cancer InstituteRecruiting
- Virginia Oncology Associates - Virginia BeachRecruiting
- Providence Regional Cancer PartnershipRecruiting
- Kadlec Clinic Hematology and OncologyRecruiting
- Northwest Medical SpecialtiesRecruiting
- Macarthur Cancer Therapy CentreRecruiting
- Kinghorn Cancer Centre; St Vincents HospitalRecruiting
- Royal North Shore Hospital; Department of Medical OncologyRecruiting
- Princess Alexandra Hospital; Cancer Trials UnitRecruiting
- Peter MacCallum Cancer Centre; Medical Oncology
- Tiroler Landeskrankenanstalten Ges.M.B.H.; Abt. Für GynäkologieRecruiting
- Ordensklinikum Linz Barmherzige Schwestern; Interne 1 - Hämato-OnkologieRecruiting
- Lkh Salzburg - Univ. Klinikum Salzburg; Iii. Medizinische Abt.Recruiting
- AKH - Medizinische Universität Wien; Department of OncologyRecruiting
- Cliniques Universitaires St-LucRecruiting
- Jessa Zkh (Campus Virga Jesse)Recruiting
- Clinique St. ElizabethRecruiting
- Hospital Sao Rafael - HSRRecruiting
- Crio - Centro Regional Integrado de OncologiaRecruiting
- Hospital Araujo Jorge; Departamento de Ginecologia E MamaRecruiting
- Oncosite - Centro de Pesquisa Clinica Em Oncologia LtdaRecruiting
- Santa Casa de Misericordia de Porto AlegreRecruiting
- Hospital Sao Lucas - PUCRSRecruiting
- Hospital Nossa Senhora da ConceicaoRecruiting
- Hospital de Base de Sao Jose do Rio PretoRecruiting
- Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria LtdaRecruiting
- Núcleo de Pesquisa São Camilo; ONCOLOGIA CLINICA / QUIMIOTERAPIARecruiting
- COC Plovdiv; First Medical Oncology DepartmentRecruiting
- Medical Center "Nadezhda Clinical" EOOD; Medical Oncology DepartmentRecruiting
- University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EADRecruiting
- Sichuan Cancer HospitalRecruiting
- West China Hospital - Sichuan University
- Chongqing Cancer HospitalRecruiting
- The First Affilicated Hospital, Sun Yat-sen University
- Guangdong Provincial People's Hospital; BreastRecruiting
- Sun Yat-sen Memorial Hospital
- Harbin Medical University Cancer Hospital
- The Affiliated Hospital of Medical College Qingdao University
- Zhongshan Hospital Fudan UniversityRecruiting
- Tianjin Medical University Cancer Institute & Hospital
- Union Hospital Tongji Medical College Huazhong University of Science and Technology
- First Affiliated Hospital of Medical College of Xi'an Jiaotong University
- Zhejiang Cancer HospitalRecruiting
- Henan Cancer HospitalRecruiting
- Masaryk?v onkologický ústav; Klinika komplexní onkologické pé?eRecruiting
- Fakultni Nemocnice Hradec Kralove; Dept of Radiotherapy & OncologyRecruiting
- Nemocnice AGEL Novy Jicin a.s.; Oddeleni radioterapie a onkologieRecruiting
- Fakultni nemocnice Olomouc; Onkologicka klinikaRecruiting
- Fakultni Poliklinika Vseobecne Fakultni Niemocnice; Onkologicka KlinikaRecruiting
- Fakultni Thomayerova nemocnice; Onkologicka klinika 1. LF UK a FTNRecruiting
- Fakultni nemocnice v Motole; Onkologicka klinika 2. LF UK a FN Motol
- Herlev Hospital; Afdeling for KræftbehandlingRecruiting
- Vejle Sygehus; Onkologisk AfdelingRecruiting
- Institut Sainte CatherineRecruiting
- CHRU BesançonRecruiting
- Polyclinique Bordeaux Nord AquitaineRecruiting
- Hopital MorvanRecruiting
- Centre Francois Baclesse; Comite SeinRecruiting
- Groupe Hospitalier Public Du Sud De L'Oise GHPSO; OncologieRecruiting
- CLCC Leon Berard LyonRecruiting
- Centre Hospitalier Uni Ire Caremeau; Radiotherapie & OncologieRecruiting
- Groupe Hospitalier DiaconessesRecruiting
- Institut Curie; Oncologie MedicaleRecruiting
- Pole Regional De CancerologieRecruiting
- HOPITAL RENE HUGUENIN, Institut Curie; Service d'Oncologie Médicale.Recruiting
- Klinikum Augsburg; FrauenklinikRecruiting
- Gemeinschaftspraxis für Hämatologie und Onkologie Dr. Reichert/Dr.JanssenRecruiting
- Hochtaunus-Kliniken gGmbH; Krankenhaus Bad Homburg; Frauenklinik
- Hochwaldkrankenhaus; Abt.Gynäkologie Geburtshilfe u.SenologieRecruiting
- Onkologische Schwerpunktpraxis KurfürstendammRecruiting
- Vivantes Klinikum Am Urban; Zentrum für Brusterkrankungen
- Gynäkologisches Zentrum BonnRecruiting
- Marienhospital BottropRecruiting
- Städtisches Klinikum DessauRecruiting
- Gynonco Düsseldorf, MVZ Medical Center GmbHRecruiting
- Frauenarztpraxis Dr. Apel, Dr. Kolpin
- Universitätsklinikum Erlangen; Frauenklinik
- Klinikum Essen-Mitte Ev. Huyssens-Stiftung / Knappschafts GmbH; Klinik für Senologie / BrustzentrumRecruiting
- AGAPLESION Markus-KrankenhausRecruiting
- Klinik Johann Wolfgang von Goethe Uni; Klinik für Frauenheilkunde und GeburtshilfeRecruiting
- Praxis für Interdisziplinäre Onkologie und Hämatologie GbRRecruiting
- St. Barbara-Klinik Hamm-Heessen GmbH; Frauenklinik
- Diakovere Henriettenstift, FrauenklinikRecruiting
- Städtisches Klinikum Karlsruhe gGmbH; FrauenklinikRecruiting
- UNI-Klinikum Campus Kiel Klinik für Gynäkologie und GeburtshilfeRecruiting
- Universitätsklinikum Leipzig; Klinik und Poliklinik für FrauenheilkundeRecruiting
- Städtische Klinik Lüneburg; FrauenklinikRecruiting
- Klinik & Poliklinik für Frauenheilkunde und Geburtshilfe, Campus InnenstadtRecruiting
- Sana Klinikum Offenbach GmbH; Klinik für Gynäkologie & Geburtshilfe
- Klinikum Ernst von Bergmann; FrauenklinikRecruiting
- Klinikum am Steinenberg Frauenklinik
- Leopoldina Krankenhaus der Stadt Schweinfurt GmbHRecruiting
- Johanniter-Krankenhaus Genthin-Stendal; Klinik Für Frauenheilkunde & GeburtshilfeRecruiting
- Anticancer Hospital Ag. Savas ; 2Nd Dept. of Oncology - Internal MedicineRecruiting
- Alexandras General Hospital of Athens; Oncology DepartmentRecruiting
- Metropolitan General HospitalRecruiting
- University General Hospital of HeraklionRecruiting
- University Hospital of Larissa;Department of Medical OncologyRecruiting
- Metropolitan Hospital; 2Nd Oncology ClinicRecruiting
- Euromedical General Clinic of Thessaloniki; Oncology DepartmentRecruiting
- Queen Mary Hospital; SurgeryRecruiting
- Pamela Youde Nethersole Eastern Hospital; Clinical OncologyRecruiting
- Tuen Mun Hospital; Clinical OncologyRecruiting
- Budapesti Szent Margit Korhaz; Onkologia OsztalyRecruiting
- Eszak-Pesti Centrumkorhaz - Honvedkorhaz; Podmaniczky utcai telephelyRecruiting
- Orszagos Onkologiai Intezet; B Belgyogyaszati OsztalyRecruiting
- Debreceni Egyetem Klinikai Kozpont ; Department of OncologyRecruiting
- Borsod-Abauj-Zemplen Megyei Korhaz Es Egyetemi Oktato Korhaz; Onkologiai OsztalyRecruiting
- Rajiv Gandhi Cancer Institute & Research Center
- Max Super Speciality Hospital; Medical OncologyRecruiting
- Hemato Oncology Clinic Ahmedabad Pvt LtdRecruiting
- Manipal Hospital; Department of OncologyRecruiting
- Tata Memorial Hospital; Dept of Medical Oncology
- HCG Manavata Cancer CentreRecruiting
- Sahyadri Super Specialty Hospital HadapsarRecruiting
- Christian Med Clg & Hspt
- TATA Medical Centre; Medical OncologyRecruiting
- AORN'S.G.Moscati; Oncologia
- U.O.C. Oncologia Medica SenologicaRecruiting
- Università degli Studi Federico II; Clinica di Oncologia Medica
- Policlinico S.Orsola-Malpighi; Istituto Oncologia R. Addarii
- A.O. Universitaria Policlinico Di Modena; OncologiaRecruiting
- Irccs Centro Di Riferimento Oncologico (CRO)Recruiting
- ASU FC S. M. DELLA MISERICORDIA; Oncologia
- Policlinico Universitario Agostino GemelliRecruiting
- ASST DEGLI SPEDALI CIVILI DI BRESCIA; Oncologia MedicaRecruiting
- Ospedale San Raffaele; Medical OncologyRecruiting
- Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 1Recruiting
- Ospedale Civile - LivornoRecruiting
- Azlenda Ospendaliero-Universitaria Pisana; C.O. Oncologia 2Recruiting
- University of Eastern Piedmont - Maggiore della Carità University HospitalRecruiting
- IRCCS Istituto Oncologico Veneto (IOV); Oncologia Medica Seconda
- International Cancer Institute (ICI)Recruiting
- Aga Khan University HospitalRecruiting
- Kyungpook National University Medical Center
- National Cancer CenterRecruiting
- Seoul National University Bundang HospitalRecruiting
- Korea University Anam HospitalRecruiting
- Seoul National University Hospital
- Severance Hospital, Yonsei University Health SystemRecruiting
- Asan Medical Center
- Gangnam Severance Hospital
- Samsung Medical Center
- Seoul St Mary's Hospital
- Korea University Guro HospitalRecruiting
- Investigacion OncofarmaceuticaRecruiting
- Health Pharma Professional Research
- Centro Medico DalindeRecruiting
- Instituto Nacional De Cancerologia; Oncology; Tumores MamariosRecruiting
- Filios Alta MedicinaRecruiting
- Centro de Investigacion Clinica de OaxacaRecruiting
- Auckland City Hospital, Cancer and Blood ResearchRecruiting
- Tauranga Hospital, Clinical Trials Unit; BOP Clinical SchoolRecruiting
- Bialostockie Centrum Onkologii; Oddzial Onkologii Klinicznej
- Uniwersyteckie Centrum Kliniczne; Klinika Onkologii i RadioterapiiRecruiting
- Narodowy Instytut Onkologii Odzia? w Gliwicach; Centrum Diagnostyki i Leczenia Chorób PiersiRecruiting
- Szpital Uniwersytecki w Krakowie, Oddzia? Kliniczny Kliniki Onkologii
- Wielkopolskie Centrum Onkologii; Oddzial Chemioterapii
- Centrum Onkologii Instytut im.M. Sklodowskiej-Curie; Klin. Nowot. Piersii i Chirurgii Rekonstruk
- Hospital CUF Tejo; Oncologia Médica e HematologiaRecruiting
- Hospital de Santa Maria; Servico de Oncologia MedicaRecruiting
- Hospital Beatriz Angelo; Departamento de OncologiaRecruiting
- Centro Hospitalar do Porto ? Hospital de Santo António; Oncologia
- IPO do Porto; Servico de Oncologia MedicaRecruiting
- Filantropia Clinical Hospital; Medical oncologyRecruiting
- Prof.dr. Alexandru Trestioreanu, The Oncology Institute; Medical oncology I
- Amethyst Cluj; Medical Oncology
- Cluj-Napoca Emergency Clinical County Hospital; Medical OncologyRecruiting
- Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj-Napoca; Radioterapie I - Oncologie
- Centrul de Oncologie Sfantul Nectarie
- Oncomed SRL
- Republican Clinical Oncological Dispensary of the Ministry of Healthcare; Chemotherapy departmentRecruiting
- Krasnoyarsk Regional Oncology Dispensary n.a. Krizhanovsky; Chemotherapy
- Oncology Dispensary#1; Out-Patient Oncology Dept
- FSBI Russian Oncology Research Center n.a. Blokhin of MOH RF
- MEDSI Clinical Hospital on Pyatnitsky Highway; Department of antitumor drug therapy
- SBIH "Moscow Clinical Scientific and Practical Center named after A.S. Loginov of DHM"
- Nizhny Novgorod Regional Clinical Oncology Center
- S-Pb clinical scientific practical center of specialized kinds of medical care (oncological)
- Medical Clinic "AB Medical group"Recruiting
- SBI of Healthcare Leningrad Regional Oncology Dispensary
- FSBI?National Medical Research Center of Oncology named after N.N.Petrov? MHRF
- SBIH Kaluga Region Clinical Oncology Dispensary
- LLC Medical and Sanitary Unit "Clinician"
- SBI of Healthcare Samara Regional Clinical Oncology Dispensary
- Regional Oncology DispensaryRecruiting
- Regional Clinical Oncology Hospital
- National Cancer Centre; Medical OncologyRecruiting
- Hospital General Universitario de Elche; Servicio de OncologiaRecruiting
- Hospital Universitari Germans Trias i Pujol; Servicio de OncologiaRecruiting
- Corporacio Sanitaria Parc Tauli; Servicio de OncologiaRecruiting
- Hospital de Jerez de la Frontera; Servicio de OncologiaRecruiting
- Complejo Hospitalario Universitario A Coruña (CHUAC); Servicio de OncologiaRecruiting
- Complejo Hospitalario Universitario de Santiago (CHUS) ; Servicio de OncologiaRecruiting
- Hospital Quiron de Madrid; Servicio de OncologiaRecruiting
- Hospital Alvaro Cunqueiro; Servicio de OncologiaRecruiting
- Hospital Universitario de Canarias;servicio de OncologiaRecruiting
- Hospital de Basurto; Servicio de OncologiaRecruiting
- Hospital del Mar; Servicio de OncologiaRecruiting
- Vall d?Hebron Institute of Oncology (VHIO), BarcelonaRecruiting
- Hospital Clinic Barcelona; Servicio de oncologiaRecruiting
- Hospital Universitario Clínico San Cecilio; Servicio de oncologia
- Hospital Juan Ramon Jimenez;Servicio de OncologiaRecruiting
- Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de OncologiaRecruiting
- Hospital General Universitario Gregorio Marañon; Servicio de OncologiaRecruiting
- Hospital Ramon y Cajal; Servicio de Oncologia
- Hospital Clinico San Carlos; Servicio de OncologiaRecruiting
- Hospital Universitario La Paz; Servicio de Oncologia
- Hospital Clinico Universitario Virgen de la Victoria; Servicio de OncologiaRecruiting
- Hospital Clinico Universitario de Salamanca; Servicio de OncologiaRecruiting
- Hospital Universitario Virgen Macarena; Servicio de OncologiaRecruiting
- Hospital Universitario Virgen del Rocio; Servicio de OncologiaRecruiting
- Hospital Clínico Universitario de Valencia; Servicio de OncologíaRecruiting
- Hospital Universitario Dr. Peset; Servicio de OncologiaRecruiting
- Hospital Universitario Miguel Servet; Servicio OncologiaRecruiting
- China Medical University Hospital; SurgeryRecruiting
- National Cheng Kung Uni Hospital; Dept of Hematology and OncologyRecruiting
- National Taiwan University Hospital ; Dept of Surgery & Hepatitis Research CenterRecruiting
- Taipei Veterans General Hospital; Department of Clinical Trial PharmacyRecruiting
- Mackay Memorial Hospital; Dept of SurgeryRecruiting
- Chulalongkorn Hospital; Medical OncologyRecruiting
- Ramathibodi Hospital; Dept of Med.-Div. of Med. Onc
- Srinagarind Hospital; Department of SurgeryRecruiting
- Songklanagarind Hospital; Department of SurgeryRecruiting
- Adana Baskent University Hospital; Medical OncologyRecruiting
- Hacettepe University Medical Faculty
- Ankara Bilkent City HospitalRecruiting
- Gazi University Medical Faculty, Oncology HospitalRecruiting
- Memorial Ankara HastanesiRecruiting
- Antalya Training and Research Hospital ; Oncology DepartmentRecruiting
- Ege University Medical Faculty; Medical Oncology Department
- Dicle University Faculty of MedicineRecruiting
- Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi
- Istanbul Faculty of MedicineRecruiting
- Istanbul University Cerrahpasa Faculty of Medicine
- Katip Celebi University Ataturk Training and Research Hospital; Oncology
- Medeniyet University Goztepe Training and Research Hospital.Recruiting
- Inonu University Medical Faculty of Medicine; Medical Oncology Department
- Medical Park Seyhan Hospital; Oncology DepartmentRecruiting
- Ac?badem Altunizade Hastanesi; OncologyRecruiting
- Uganda Cancer InstituteRecruiting
- Uzhgorod Central City Clinical Hospital
- Municipal Noncommercial Institution Regional Center of OncologyRecruiting
- Municipal non profit enterprise of Sumy Regional Council Sumy Regional Clinical Oncology DispRecruiting
- MI "Clinical Oncological Dispensary" of Dnipro Reg Council; chemotherapy department
- Innovacia Cancer CenterRecruiting
- CI Dnipropetrovsk CMCH #4 of Dnipropetrovsk RC SI Dnipropetrovsk MA of MOHU Ch of Oncology and MRRecruiting
- Municipal Institution Kirovograd Regional Oncology DispensaryRecruiting
- Kyiv City Clinical Oncological CenterRecruiting
- Belfast City Hospital
- Blackpool Victoria HospitalRecruiting
- Bradford Royal Infirmary; Oncology DepartmentRecruiting
- Royal Sussex County Hospital
- Addenbrookes Hospital
- Velindre Cancer Centre; Clinical Trials UnitRecruiting
- Cheltenham General HospitalRecruiting
- Royal Cornwall Hospital; Dept of Clinical Oncology
- Hairmyres Hospital
- Raigmore Hospital
- Barts & London School of Med; Medical OncologyRecruiting
- University College London HospitalRecruiting
- Royal Free HospitalRecruiting
- Royal Marsden Hospital - LondonRecruiting
- Christie Hospital NHS TrustRecruiting
- Mount Vernon Cancer Centre
- Nottingham City Hospital
- Royal Preston HospitalRecruiting
- Glan Clywd Hospital
- Musgrove Park HospitalRecruiting
- Royal Marsden Hospital - SurreyRecruiting
- Walsall Manor Hospital
Arms of the Study
Arm 1
Arm 2
Arm Type
Active Comparator
Experimental
Arm Label
Arm A: Placebo + Trastuzumab Emtansine
Arm B: Atezolizumab + Trastuzumab Emtansine
Arm Description
Participants will receive an intravenous (IV) infusion of placebo prior to the IV infusion of trastuzumab emtansine on Day 1 of each 21-day cycle for a total of 14 cycles.
Participants will receive an IV infusion of atezolizumab prior to the IV infusion of trastuzumab emtansine on Day 1 of each 21-day cycle for a total of 14 cycles.
Outcomes
Primary Outcome Measures
Invasive Disease-free Survival (IDFS)
IDFS event is defined as the time from randomization to the first occurrence of the following events: ipsilateral invasive breast tumor recurrence, ipsilateral local-regional invasive breast cancer recurrence, contralateral invasive breast cancer, distant recurrence, death from any cause.
Secondary Outcome Measures
IDFS Including Second Primary Non-breast Invasive Cancer
Disease-free Survival (DFS)
Overall Survival (OS)
Distant Recurrence-free Interval (DRFI)
Number of Participants with Clinically Meaningful Deterioration in Global Health Status/Quality of Life (GHS/QoL) Physical, Role, and Cognitive Function
Clinically Meaningful Deterioration will be Measured by Scales of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire for Cancer (EORTC QLQ C30)
Mean Absolute Scores in GHS/QoL, Physical, Role, and Cognitive Function, as Assessed Using the EORTC QLQ-C30
The European Organisation for Research and Treatment of Cancer Quality of Life-Core 30 Questionnaire (EORTC QLQ-C30) is a self-reported measure. Functioning and symptoms items are scored on a 4-point scale: 1=Not at all, 2=A little, 3=Quite a bit, 4=Very much. GHS and QoL items are scored on a 7-point scale: 1=Very poor, 2, 3, 4, 5, 6, 7=Excellent. Scores will be transformed to a range of 0 to 100, with higher scores (i.e. closer to 100) reflecting better functioning, better GHS/QoL, and worse symptoms.
Mean Change From Baseline Scores in GHS/QoL, Physical, Role, and Cognitive Function, as Assessed Using the EORTC QLQ-C30
The European Organisation for Research and Treatment of Cancer Quality of Life-Core 30 Questionnaire (EORTC QLQ-C30) is a self-reported measure. Functioning and symptoms items are scored on a 4-point scale: 1=Not at all, 2=A little, 3=Quite a bit, 4=Very much. GHS and QoL items are scored on a 7-point scale: 1=Very poor, 2, 3, 4, 5, 6, 7=Excellent. Scores will be transformed to a range of 0 to 100, with higher scores (i.e. closer to 100) reflecting better functioning, better GHS/QoL, and worse symptoms.
Percentage of Participants with Adverse Events (AEs) According to National Cancer Institute Common Terminology Criteria for Adverse Events Version 5.0 (NCI CTCAE v5.0)
Maximum Serum Concentrations (Cmax) for Atezolizumab
Cmax for Trastuzumab Emtansine
Cmax for Total Trastuzumab
Cmax for DM1
DM1 = a thiol-containing maytansinoid anti-microtubule agent; N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine
Minimum Serum Concentrations (Cmin) for Atezolizumab
Percentage of Participants with Anti-drug Antibodies (ADAs) to Atezolizumab
Percentage of Participants with ADAs to Trastuzumab Emtansine
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT04873362
Brief Title
A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy
Acronym
Astefania
Official Title
A Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy
Study Type
Interventional
2. Study Status
Record Verification Date
October 2023
Overall Recruitment Status
Recruiting
Study Start Date
May 4, 2021 (Actual)
Primary Completion Date
June 25, 2026 (Anticipated)
Study Completion Date
June 29, 2035 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Hoffmann-La Roche
4. Oversight
Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
This is a Phase III, two-arm, randomized, double-blind placebo-controlled study in participants with HER2-positive primary breast cancer who have received preoperative chemotherapy and HER2-directed therapy, including trastuzumab followed by surgery, with a finding of residual invasive disease in the breast and/or axillary lymph nodes.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Breast Cancer
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigator
Allocation
Randomized
Enrollment
1700 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Arm A: Placebo + Trastuzumab Emtansine
Arm Type
Active Comparator
Arm Description
Participants will receive an intravenous (IV) infusion of placebo prior to the IV infusion of trastuzumab emtansine on Day 1 of each 21-day cycle for a total of 14 cycles.
Arm Title
Arm B: Atezolizumab + Trastuzumab Emtansine
Arm Type
Experimental
Arm Description
Participants will receive an IV infusion of atezolizumab prior to the IV infusion of trastuzumab emtansine on Day 1 of each 21-day cycle for a total of 14 cycles.
Intervention Type
Drug
Intervention Name(s)
Atezolizumab
Other Intervention Name(s)
Tecentriq, RO5541267, MPDL3280A
Intervention Description
Atezolizumab will be administered at a dose of 1200 mg every three weeks (Q3W) for 14 cycles.
Intervention Type
Drug
Intervention Name(s)
Trastuzumab Emtansine
Other Intervention Name(s)
Kadcyla, T-DM1, RO5304020
Intervention Description
Trastuzumab emtansine will be administered at a dose of 3.6 mg/kg Q3W for 14 weeks.
Intervention Type
Drug
Intervention Name(s)
Placebo
Intervention Description
Placebo matched to atezolizumab will be administered at a dose of 1200 mg Q3W for 14 cycles.
Intervention Type
Drug
Intervention Name(s)
Trastuzumab
Other Intervention Name(s)
Herceptin
Intervention Description
Trastuzumab will be used to complete 14 cycles of study treatment if trastuzumab emtansine is discontinued for toxicity not considered to be related to the trastuzumab component of the drug.
Primary Outcome Measure Information:
Title
Invasive Disease-free Survival (IDFS)
Description
IDFS event is defined as the time from randomization to the first occurrence of the following events: ipsilateral invasive breast tumor recurrence, ipsilateral local-regional invasive breast cancer recurrence, contralateral invasive breast cancer, distant recurrence, death from any cause.
Time Frame
From randomization up to approximately 6 years
Secondary Outcome Measure Information:
Title
IDFS Including Second Primary Non-breast Invasive Cancer
Time Frame
From baseline up to 10 years
Title
Disease-free Survival (DFS)
Time Frame
From baseline up to 10 years
Title
Overall Survival (OS)
Time Frame
From baseline up to 10 years
Title
Distant Recurrence-free Interval (DRFI)
Time Frame
From baseline up to 10 years
Title
Number of Participants with Clinically Meaningful Deterioration in Global Health Status/Quality of Life (GHS/QoL) Physical, Role, and Cognitive Function
Description
Clinically Meaningful Deterioration will be Measured by Scales of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire for Cancer (EORTC QLQ C30)
Time Frame
From baseline until 2 years after study treatment completion/discontinuation visit (approximately 3 years)
Title
Mean Absolute Scores in GHS/QoL, Physical, Role, and Cognitive Function, as Assessed Using the EORTC QLQ-C30
Description
The European Organisation for Research and Treatment of Cancer Quality of Life-Core 30 Questionnaire (EORTC QLQ-C30) is a self-reported measure. Functioning and symptoms items are scored on a 4-point scale: 1=Not at all, 2=A little, 3=Quite a bit, 4=Very much. GHS and QoL items are scored on a 7-point scale: 1=Very poor, 2, 3, 4, 5, 6, 7=Excellent. Scores will be transformed to a range of 0 to 100, with higher scores (i.e. closer to 100) reflecting better functioning, better GHS/QoL, and worse symptoms.
Time Frame
From baseline until 2 years after study treatment completion/discontinuation visit (approximately 3 years)
Title
Mean Change From Baseline Scores in GHS/QoL, Physical, Role, and Cognitive Function, as Assessed Using the EORTC QLQ-C30
Description
The European Organisation for Research and Treatment of Cancer Quality of Life-Core 30 Questionnaire (EORTC QLQ-C30) is a self-reported measure. Functioning and symptoms items are scored on a 4-point scale: 1=Not at all, 2=A little, 3=Quite a bit, 4=Very much. GHS and QoL items are scored on a 7-point scale: 1=Very poor, 2, 3, 4, 5, 6, 7=Excellent. Scores will be transformed to a range of 0 to 100, with higher scores (i.e. closer to 100) reflecting better functioning, better GHS/QoL, and worse symptoms.
Time Frame
From baseline until 2 years after study treatment completion/discontinuation visit (approximately 3 years)
Title
Percentage of Participants with Adverse Events (AEs) According to National Cancer Institute Common Terminology Criteria for Adverse Events Version 5.0 (NCI CTCAE v5.0)
Time Frame
From baseline up to 10 years
Title
Maximum Serum Concentrations (Cmax) for Atezolizumab
Time Frame
Day 1 of Cycles 1 and 4 pre-infusion, Day 1 of Cycles 1 and 4 after 30 minutes post-infusion, Day 1 of Cycles 2, 3 and 8 pre-infusion (cycle=21 days) and at study treatment completion/discontinuation visit (approximately 11 months after Cycle 1 Day 1)
Title
Cmax for Trastuzumab Emtansine
Time Frame
Day 1 of Cycles 1 and 4 pre-infusion, Day 1 of Cycles 1 and 4 after 30 minutes post-infusion, (cycle=21 days) and at study treatment completion/discontinuation visit (approximately 11 months after Cycle 1 Day 1)
Title
Cmax for Total Trastuzumab
Time Frame
Day 1 of Cycles 1 and 4 pre-infusion, Day 1 of Cycles 1 and 4 after 30 minutes post-infusion, (cycle=21 days) and at study treatment completion/discontinuation visit (approximately 11 months after Cycle 1 Day 1)
Title
Cmax for DM1
Description
DM1 = a thiol-containing maytansinoid anti-microtubule agent; N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine
Time Frame
Day 1 of Cycles 1 and 4 pre-infusion, Day 1 of Cycles 1 and 4 after 30 minutes post-infusion, (cycle=21 days) and at study treatment completion/discontinuation visit (approximately 11 months after Cycle 1 Day 1)
Title
Minimum Serum Concentrations (Cmin) for Atezolizumab
Time Frame
Day 1 of Cycles 1 and 4 pre-infusion, Day 1 of Cycles 1 and 4 after 30 minutes post-infusion, Day 1 of Cycles 2, 3 and 8 (cycle=21 days) and at study treatment completion/discontinuation visit (approximately 11 months after Cycle 1 Day 1)
Title
Percentage of Participants with Anti-drug Antibodies (ADAs) to Atezolizumab
Time Frame
Day 1 of Cycles 1 and 4 pre-infusion, Day 1 of Cycles 1 and 4 after 30 minutes post-infusion, Day 1 of Cycles 2, 3 and 8 (cycle=21 days) and at study treatment completion/discontinuation visit (approximately 11 months after Cycle 1 Day 1)
Title
Percentage of Participants with ADAs to Trastuzumab Emtansine
Time Frame
Day 1 of Cycles 1 and 4 pre-infusion, Day 1 of Cycles 1 and 4 after 30 minutes post-infusion, (cycle=21 days) and at study treatment completion/discontinuation visit (approximately 11 months after Cycle 1 Day 1)
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Histologically confirmed invasive breast carcinoma
Centrally-confirmed human epidermal growth factor receptor 2 (HER2)-positive invasive breast cancer
Centrally confirmed PD-L1 and hormone receptor status
Clinical stage at disease presentation (prior to neoadjuvant therapy): cT4/anyN/M0, any cT/N2-3/M0, or cT1-3/N0-1/M0 (participants with cT1mi/T1a/T1b/N0 are not eligible)
Completion of pre-operative systemic chemotherapy including at least 9 weeks of taxane and 9 weeks of trastuzumab (anthracycline and/or additional HER2-targeted agents are permitted)
<=12 weeks between primary surgery and randomization
Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1
Screening left ventricular ejection fraction (LVEF) >= 50% and no decrease in LVEF by >15% from the pre-chemotherapy LVEF. If no pre-chemotherapy LVEF, screening LVEF >= 55%
Life expectancy >= 6 months
Adequate hematologic and end organ function
Exclusion Criteria:
Stage IV breast cancer
An overall response of disease progression according to the investigator at the conclusion of preoperative systemic therapy
Prior treatment with T-DM1, or atezolizumab, or other immune checkpoint inhibitors
History of exposure to various cumulative doses of anthracyclines
History of other malignancy within 5 years prior to screening, except for appropriately treated carcinoma in situ of the cervix, non-melanoma skin carcinoma, Stage I uterine cancer, or ductal carcinoma in situ (DCIS)
Current grade >=2 peripheral neuropathy
History of idiopathic pulmonary fibrosis, organizing pneumonia, or pneumonitis
History of or active autoimmune disease or immune deficiency
Treatment with immunostimulatory or immunosuppressive agents
Cardiopulmonary dysfunction
Any known active liver disease
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Reference Study ID Number: WO42633 https://forpatients.roche.com/
Phone
888-662-6728 (U.S. and Canada)
Email
global-roche-genentech-trials@gene.com
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Clinical Trials
Organizational Affiliation
Hoffmann-La Roche
Official's Role
Study Director
Facility Information:
Facility Name
Alabama Oncology
City
Alabaster
State/Province
Alabama
ZIP/Postal Code
35007
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Roy and Patricia Disney Family Cancer Center- Providence Saint Joseph Medical Center
City
Burbank
State/Province
California
ZIP/Postal Code
91505
Country
United States
Individual Site Status
Recruiting
Facility Name
Innovation Clinical Research Institute
City
Cerritos
State/Province
California
ZIP/Postal Code
90703
Country
United States
Individual Site Status
Recruiting
Facility Name
California Cancer Associate for Research & Excellence
City
Fresno
State/Province
California
ZIP/Postal Code
93720
Country
United States
Individual Site Status
Recruiting
Facility Name
Glendale Adventist Medical Ctr
City
Glendale
State/Province
California
ZIP/Postal Code
91206
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
UCLA Medical Center
City
Santa Monica
State/Province
California
ZIP/Postal Code
90404
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Cancer Specialists; North Florida ;Jacksonville (AC Skinner Pkwy)
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32256
Country
United States
Individual Site Status
Recruiting
Facility Name
Florida Cancer Specialists
City
West Palm Beach
State/Province
Florida
ZIP/Postal Code
33401
Country
United States
Individual Site Status
Recruiting
Facility Name
University Cancer & Blood Center, LLC; Research
City
Athens
State/Province
Georgia
ZIP/Postal Code
30607
Country
United States
Individual Site Status
Recruiting
Facility Name
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital
City
Carrollton
State/Province
Georgia
ZIP/Postal Code
30117
Country
United States
Individual Site Status
Recruiting
Facility Name
Elmhurst Memorial Healthcare
City
Elmhurst
State/Province
Illinois
ZIP/Postal Code
60126
Country
United States
Individual Site Status
Withdrawn
Facility Name
Edward Cancer Center Naperville
City
Naperville
State/Province
Illinois
ZIP/Postal Code
60540
Country
United States
Individual Site Status
Withdrawn
Facility Name
Edward Cancer Center Plainfield
City
Plainfield
State/Province
Illinois
ZIP/Postal Code
60585
Country
United States
Individual Site Status
Withdrawn
Facility Name
University of Iowa
City
Iowa City
State/Province
Iowa
ZIP/Postal Code
52242-1086
Country
United States
Individual Site Status
Recruiting
Facility Name
Pontchartrain Cancer Center
City
Covington
State/Province
Louisiana
ZIP/Postal Code
70433
Country
United States
Individual Site Status
Recruiting
Facility Name
New England Cancer Specialists
City
Scarborough
State/Province
Maine
ZIP/Postal Code
04074
Country
United States
Individual Site Status
Recruiting
Facility Name
University of Maryland Medical Center
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21201
Country
United States
Individual Site Status
Recruiting
Facility Name
Mercy Medical Center
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21202
Country
United States
Individual Site Status
Recruiting
Facility Name
Greater Baltimore Med Ctr; Dept Berman Cancer Institute
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21204
Country
United States
Individual Site Status
Recruiting
Facility Name
Henry Ford Health System; Clinical Trials Office; Clinical Trials Office
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48202
Country
United States
Individual Site Status
Recruiting
Facility Name
Jackson Oncology Associates, PLLC
City
Jackson
State/Province
Mississippi
ZIP/Postal Code
39202
Country
United States
Individual Site Status
Recruiting
Facility Name
Central Care Cancer Center; NC
City
Bolivar
State/Province
Missouri
ZIP/Postal Code
65613
Country
United States
Individual Site Status
Recruiting
Facility Name
MD Anderson Cancer Center at Cooper
City
Camden
State/Province
New Jersey
ZIP/Postal Code
08103
Country
United States
Individual Site Status
Withdrawn
Facility Name
Jersey Shore University Medical Centre
City
Neptune
State/Province
New Jersey
ZIP/Postal Code
07753
Country
United States
Individual Site Status
Withdrawn
Facility Name
The Valley Hospital
City
Paramus
State/Province
New Jersey
ZIP/Postal Code
07652
Country
United States
Individual Site Status
Recruiting
Facility Name
Mount Sinai Medical Center
City
New York
State/Province
New York
ZIP/Postal Code
10029
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Great Lakes Cancer Center
City
Williamsville
State/Province
New York
ZIP/Postal Code
14221
Country
United States
Individual Site Status
Withdrawn
Facility Name
Messino Cancer Centers
City
Asheville
State/Province
North Carolina
ZIP/Postal Code
28806
Country
United States
Individual Site Status
Withdrawn
Facility Name
Levine Cancer Institute
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28204
Country
United States
Individual Site Status
Recruiting
Facility Name
Providence Health & Services - Oregon
City
Portland
State/Province
Oregon
ZIP/Postal Code
97213
Country
United States
Individual Site Status
Withdrawn
Facility Name
Bryn Mawr Hospital
City
Bryn Mawr
State/Province
Pennsylvania
ZIP/Postal Code
19010-3121
Country
United States
Individual Site Status
Recruiting
Facility Name
Abramson Cancer Center; Univ of Pennsylvania; Clinical Research Unit
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19106
Country
United States
Individual Site Status
Recruiting
Facility Name
Lankenau Hospital
City
Wynnewood
State/Province
Pennsylvania
ZIP/Postal Code
19096
Country
United States
Individual Site Status
Recruiting
Facility Name
Roper St. Francis Healthcare
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29414
Country
United States
Individual Site Status
Recruiting
Facility Name
Avera Cancer Institute
City
Sioux Falls
State/Province
South Dakota
ZIP/Postal Code
57105
Country
United States
Individual Site Status
Completed
Facility Name
SCRI Tennessee Oncology Chattanooga
City
Chattanooga
State/Province
Tennessee
ZIP/Postal Code
37404
Country
United States
Individual Site Status
Withdrawn
Facility Name
The West Clinic; West Cancer Center
City
Germantown
State/Province
Tennessee
ZIP/Postal Code
38138
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Thompson Cancer Survival Center
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37916-2305
Country
United States
Individual Site Status
Recruiting
Facility Name
Tennessee Oncology; Sarah Cannon Research Institute
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37203
Country
United States
Individual Site Status
Withdrawn
Facility Name
Joe Arrington Cancer Research & Treatment Center
City
Lubbock
State/Province
Texas
ZIP/Postal Code
79410
Country
United States
Individual Site Status
Recruiting
Facility Name
Mays Cancer Center at UT Health San Antonio MD Anderson Cancer
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Individual Site Status
Recruiting
Facility Name
Hematology Oncology Associates of Fredericksburg, Inc.
City
Fredericksburg
State/Province
Virginia
ZIP/Postal Code
22408
Country
United States
Individual Site Status
Recruiting
Facility Name
Virginia Oncology Associates - New Port News
City
Newport News
State/Province
Virginia
ZIP/Postal Code
23606
Country
United States
Individual Site Status
Recruiting
Facility Name
Virginia Oncology Associates
City
Norfolk
State/Province
Virginia
ZIP/Postal Code
23502
Country
United States
Individual Site Status
Recruiting
Facility Name
Virginia Cancer Institute
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23229
Country
United States
Individual Site Status
Recruiting
Facility Name
Virginia Oncology Associates - Virginia Beach
City
Virginia Beach
State/Province
Virginia
ZIP/Postal Code
23456
Country
United States
Individual Site Status
Recruiting
Facility Name
Providence Regional Cancer Partnership
City
Everett
State/Province
Washington
ZIP/Postal Code
98201
Country
United States
Individual Site Status
Recruiting
Facility Name
Kadlec Clinic Hematology and Oncology
City
Kennewick
State/Province
Washington
ZIP/Postal Code
99336-7774
Country
United States
Individual Site Status
Recruiting
Facility Name
Northwest Medical Specialties
City
Tacoma
State/Province
Washington
ZIP/Postal Code
98405
Country
United States
Individual Site Status
Recruiting
Facility Name
Macarthur Cancer Therapy Centre
City
Campbelltown
State/Province
New South Wales
ZIP/Postal Code
2560
Country
Australia
Individual Site Status
Recruiting
Facility Name
Kinghorn Cancer Centre; St Vincents Hospital
City
Darlinghurst
State/Province
New South Wales
ZIP/Postal Code
2010
Country
Australia
Individual Site Status
Recruiting
Facility Name
Royal North Shore Hospital; Department of Medical Oncology
City
St Leonards
State/Province
New South Wales
ZIP/Postal Code
2065
Country
Australia
Individual Site Status
Recruiting
Facility Name
Princess Alexandra Hospital; Cancer Trials Unit
City
Woolloongabba
State/Province
Queensland
ZIP/Postal Code
4102
Country
Australia
Individual Site Status
Recruiting
Facility Name
Peter MacCallum Cancer Centre; Medical Oncology
City
Melbourne
State/Province
Victoria
ZIP/Postal Code
3000
Country
Australia
Individual Site Status
Withdrawn
Facility Name
Tiroler Landeskrankenanstalten Ges.M.B.H.; Abt. Für Gynäkologie
City
Innsbruck
ZIP/Postal Code
6020
Country
Austria
Individual Site Status
Recruiting
Facility Name
Ordensklinikum Linz Barmherzige Schwestern; Interne 1 - Hämato-Onkologie
City
Linz
ZIP/Postal Code
4010
Country
Austria
Individual Site Status
Recruiting
Facility Name
Lkh Salzburg - Univ. Klinikum Salzburg; Iii. Medizinische Abt.
City
Salzburg
ZIP/Postal Code
5020
Country
Austria
Individual Site Status
Recruiting
Facility Name
AKH - Medizinische Universität Wien; Department of Oncology
City
Vienna
ZIP/Postal Code
1090
Country
Austria
Individual Site Status
Recruiting
Facility Name
Cliniques Universitaires St-Luc
City
Bruxelles
ZIP/Postal Code
1200
Country
Belgium
Individual Site Status
Recruiting
Facility Name
Jessa Zkh (Campus Virga Jesse)
City
Hasselt
ZIP/Postal Code
3500
Country
Belgium
Individual Site Status
Recruiting
Facility Name
Clinique St. Elizabeth
City
Namur
ZIP/Postal Code
5000
Country
Belgium
Individual Site Status
Recruiting
Facility Name
Hospital Sao Rafael - HSR
City
Salvador
State/Province
BA
ZIP/Postal Code
41253-190
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Crio - Centro Regional Integrado de Oncologia
City
Fortaleza
State/Province
CE
ZIP/Postal Code
60336-232
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Hospital Araujo Jorge; Departamento de Ginecologia E Mama
City
Goiania
State/Province
GO
ZIP/Postal Code
74605-070
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda
City
Ijui
State/Province
RS
ZIP/Postal Code
98700-000
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Santa Casa de Misericordia de Porto Alegre
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90020-090
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Hospital Sao Lucas - PUCRS
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90610-000
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Hospital Nossa Senhora da Conceicao
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
91350-200
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Hospital de Base de Sao Jose do Rio Preto
City
Sao Jose do Rio Preto
State/Province
SP
ZIP/Postal Code
15090-000
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda
City
Sao Paulo
State/Province
SP
ZIP/Postal Code
01317-001
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Núcleo de Pesquisa São Camilo; ONCOLOGIA CLINICA / QUIMIOTERAPIA
City
Sao Paulo
State/Province
SP
ZIP/Postal Code
04014-002
Country
Brazil
Individual Site Status
Recruiting
Facility Name
COC Plovdiv; First Medical Oncology Department
City
Plovdiv
ZIP/Postal Code
4004
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
Medical Center "Nadezhda Clinical" EOOD; Medical Oncology Department
City
Sofia
ZIP/Postal Code
1330
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD
City
Sofia
ZIP/Postal Code
1527
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
Sichuan Cancer Hospital
City
Chengdu City
ZIP/Postal Code
610041
Country
China
Individual Site Status
Recruiting
Facility Name
West China Hospital - Sichuan University
City
Chengdu City
ZIP/Postal Code
610047
Country
China
Individual Site Status
Active, not recruiting
Facility Name
Chongqing Cancer Hospital
City
Chongqing
ZIP/Postal Code
400030
Country
China
Individual Site Status
Recruiting
Facility Name
The First Affilicated Hospital, Sun Yat-sen University
City
Guangzhou City
ZIP/Postal Code
510080
Country
China
Individual Site Status
Active, not recruiting
Facility Name
Guangdong Provincial People's Hospital; Breast
City
Guangzhou City
ZIP/Postal Code
510180
Country
China
Individual Site Status
Recruiting
Facility Name
Sun Yat-sen Memorial Hospital
City
Guangzhou
ZIP/Postal Code
510000
Country
China
Individual Site Status
Active, not recruiting
Facility Name
Harbin Medical University Cancer Hospital
City
Harbin
ZIP/Postal Code
150081
Country
China
Individual Site Status
Active, not recruiting
Facility Name
The Affiliated Hospital of Medical College Qingdao University
City
Qingdao
ZIP/Postal Code
266003
Country
China
Individual Site Status
Withdrawn
Facility Name
Zhongshan Hospital Fudan University
City
Shanghai
ZIP/Postal Code
200032
Country
China
Individual Site Status
Recruiting
Facility Name
Tianjin Medical University Cancer Institute & Hospital
City
Tianjing
ZIP/Postal Code
300060
Country
China
Individual Site Status
Active, not recruiting
Facility Name
Union Hospital Tongji Medical College Huazhong University of Science and Technology
City
Wuhan City
ZIP/Postal Code
430023
Country
China
Individual Site Status
Active, not recruiting
Facility Name
First Affiliated Hospital of Medical College of Xi'an Jiaotong University
City
Xi'an
ZIP/Postal Code
710061
Country
China
Individual Site Status
Active, not recruiting
Facility Name
Zhejiang Cancer Hospital
City
Zhejiang
ZIP/Postal Code
310022
Country
China
Individual Site Status
Recruiting
Facility Name
Henan Cancer Hospital
City
Zhengzhou
ZIP/Postal Code
450008
Country
China
Individual Site Status
Recruiting
Facility Name
Masaryk?v onkologický ústav; Klinika komplexní onkologické pé?e
City
Brno
ZIP/Postal Code
656 53
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Fakultni Nemocnice Hradec Kralove; Dept of Radiotherapy & Oncology
City
Hradec Kralove
ZIP/Postal Code
500 05
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Nemocnice AGEL Novy Jicin a.s.; Oddeleni radioterapie a onkologie
City
Novy Jicin
ZIP/Postal Code
741 01
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Fakultni nemocnice Olomouc; Onkologicka klinika
City
Olomouc
ZIP/Postal Code
779 00
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Fakultni Poliklinika Vseobecne Fakultni Niemocnice; Onkologicka Klinika
City
Praha 2
ZIP/Postal Code
128 08
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Fakultni Thomayerova nemocnice; Onkologicka klinika 1. LF UK a FTN
City
Praha 4 - Krc
ZIP/Postal Code
140 59
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Fakultni nemocnice v Motole; Onkologicka klinika 2. LF UK a FN Motol
City
Praha 5
ZIP/Postal Code
150 06
Country
Czechia
Individual Site Status
Withdrawn
Facility Name
Herlev Hospital; Afdeling for Kræftbehandling
City
Herlev
ZIP/Postal Code
2730
Country
Denmark
Individual Site Status
Recruiting
Facility Name
Vejle Sygehus; Onkologisk Afdeling
City
Vejle
ZIP/Postal Code
7100
Country
Denmark
Individual Site Status
Recruiting
Facility Name
Institut Sainte Catherine
City
Avignon
ZIP/Postal Code
84082
Country
France
Individual Site Status
Recruiting
Facility Name
CHRU Besançon
City
Besançon
ZIP/Postal Code
25030
Country
France
Individual Site Status
Recruiting
Facility Name
Polyclinique Bordeaux Nord Aquitaine
City
Bordeaux
ZIP/Postal Code
33300
Country
France
Individual Site Status
Recruiting
Facility Name
Hopital Morvan
City
Brest
ZIP/Postal Code
29200
Country
France
Individual Site Status
Recruiting
Facility Name
Centre Francois Baclesse; Comite Sein
City
Caen
ZIP/Postal Code
14076
Country
France
Individual Site Status
Recruiting
Facility Name
Groupe Hospitalier Public Du Sud De L'Oise GHPSO; Oncologie
City
Creil Cedex 1
ZIP/Postal Code
60109
Country
France
Individual Site Status
Recruiting
Facility Name
CLCC Leon Berard Lyon
City
Lyon
ZIP/Postal Code
69008
Country
France
Individual Site Status
Recruiting
Facility Name
Centre Hospitalier Uni Ire Caremeau; Radiotherapie & Oncologie
City
Nimes
ZIP/Postal Code
30029
Country
France
Individual Site Status
Recruiting
Facility Name
Groupe Hospitalier Diaconesses
City
Paris
ZIP/Postal Code
75020
Country
France
Individual Site Status
Recruiting
Facility Name
Institut Curie; Oncologie Medicale
City
Paris
ZIP/Postal Code
75231
Country
France
Individual Site Status
Recruiting
Facility Name
Pole Regional De Cancerologie
City
Poitiers
ZIP/Postal Code
86021
Country
France
Individual Site Status
Recruiting
Facility Name
HOPITAL RENE HUGUENIN, Institut Curie; Service d'Oncologie Médicale.
City
Saint-Cloud
ZIP/Postal Code
92210
Country
France
Individual Site Status
Recruiting
Facility Name
Klinikum Augsburg; Frauenklinik
City
Augsburg
ZIP/Postal Code
86156
Country
Germany
Individual Site Status
Recruiting
Facility Name
Gemeinschaftspraxis für Hämatologie und Onkologie Dr. Reichert/Dr.Janssen
City
Aurich
ZIP/Postal Code
26603
Country
Germany
Individual Site Status
Recruiting
Facility Name
Hochtaunus-Kliniken gGmbH; Krankenhaus Bad Homburg; Frauenklinik
City
Bad Homburg vdH
ZIP/Postal Code
61352
Country
Germany
Individual Site Status
Withdrawn
Facility Name
Hochwaldkrankenhaus; Abt.Gynäkologie Geburtshilfe u.Senologie
City
Bad Nauheim
ZIP/Postal Code
61231
Country
Germany
Individual Site Status
Recruiting
Facility Name
Onkologische Schwerpunktpraxis Kurfürstendamm
City
Berlin
ZIP/Postal Code
10707
Country
Germany
Individual Site Status
Recruiting
Facility Name
Vivantes Klinikum Am Urban; Zentrum für Brusterkrankungen
City
Berlin
ZIP/Postal Code
10967
Country
Germany
Individual Site Status
Withdrawn
Facility Name
Gynäkologisches Zentrum Bonn
City
Bonn
ZIP/Postal Code
53111
Country
Germany
Individual Site Status
Recruiting
Facility Name
Marienhospital Bottrop
City
Bottrop
ZIP/Postal Code
46236
Country
Germany
Individual Site Status
Recruiting
Facility Name
Städtisches Klinikum Dessau
City
Dessau-Roßlau
ZIP/Postal Code
06847
Country
Germany
Individual Site Status
Recruiting
Facility Name
Gynonco Düsseldorf, MVZ Medical Center GmbH
City
Düsseldorf
ZIP/Postal Code
40235
Country
Germany
Individual Site Status
Recruiting
Facility Name
Frauenarztpraxis Dr. Apel, Dr. Kolpin
City
Erfurt
ZIP/Postal Code
99084
Country
Germany
Individual Site Status
Active, not recruiting
Facility Name
Universitätsklinikum Erlangen; Frauenklinik
City
Erlangen
ZIP/Postal Code
91054
Country
Germany
Individual Site Status
Completed
Facility Name
Klinikum Essen-Mitte Ev. Huyssens-Stiftung / Knappschafts GmbH; Klinik für Senologie / Brustzentrum
City
Essen
ZIP/Postal Code
45136
Country
Germany
Individual Site Status
Recruiting
Facility Name
AGAPLESION Markus-Krankenhaus
City
Frankfurt
ZIP/Postal Code
60431
Country
Germany
Individual Site Status
Recruiting
Facility Name
Klinik Johann Wolfgang von Goethe Uni; Klinik für Frauenheilkunde und Geburtshilfe
City
Frankfurt
ZIP/Postal Code
60596
Country
Germany
Individual Site Status
Recruiting
Facility Name
Praxis für Interdisziplinäre Onkologie und Hämatologie GbR
City
Freiburg
ZIP/Postal Code
79110
Country
Germany
Individual Site Status
Recruiting
Facility Name
St. Barbara-Klinik Hamm-Heessen GmbH; Frauenklinik
City
Hamm
ZIP/Postal Code
59073
Country
Germany
Individual Site Status
Withdrawn
Facility Name
Diakovere Henriettenstift, Frauenklinik
City
Hannover
ZIP/Postal Code
30559
Country
Germany
Individual Site Status
Recruiting
Facility Name
Städtisches Klinikum Karlsruhe gGmbH; Frauenklinik
City
Karlsruhe
ZIP/Postal Code
76133
Country
Germany
Individual Site Status
Recruiting
Facility Name
UNI-Klinikum Campus Kiel Klinik für Gynäkologie und Geburtshilfe
City
Kiel
ZIP/Postal Code
24105
Country
Germany
Individual Site Status
Recruiting
Facility Name
Universitätsklinikum Leipzig; Klinik und Poliklinik für Frauenheilkunde
City
Leipzig
ZIP/Postal Code
04103
Country
Germany
Individual Site Status
Recruiting
Facility Name
Städtische Klinik Lüneburg; Frauenklinik
City
Lüneburg
ZIP/Postal Code
21339
Country
Germany
Individual Site Status
Recruiting
Facility Name
Klinik & Poliklinik für Frauenheilkunde und Geburtshilfe, Campus Innenstadt
City
München
ZIP/Postal Code
80336
Country
Germany
Individual Site Status
Recruiting
Facility Name
Sana Klinikum Offenbach GmbH; Klinik für Gynäkologie & Geburtshilfe
City
Offenbach
ZIP/Postal Code
63069
Country
Germany
Individual Site Status
Withdrawn
Facility Name
Klinikum Ernst von Bergmann; Frauenklinik
City
Potsdam
ZIP/Postal Code
14467
Country
Germany
Individual Site Status
Recruiting
Facility Name
Klinikum am Steinenberg Frauenklinik
City
Reutlingen
ZIP/Postal Code
72764
Country
Germany
Individual Site Status
Withdrawn
Facility Name
Leopoldina Krankenhaus der Stadt Schweinfurt GmbH
City
Schweinfurt
ZIP/Postal Code
97422
Country
Germany
Individual Site Status
Recruiting
Facility Name
Johanniter-Krankenhaus Genthin-Stendal; Klinik Für Frauenheilkunde & Geburtshilfe
City
Stendal
ZIP/Postal Code
39576
Country
Germany
Individual Site Status
Recruiting
Facility Name
Anticancer Hospital Ag. Savas ; 2Nd Dept. of Oncology - Internal Medicine
City
Athens
ZIP/Postal Code
115 22
Country
Greece
Individual Site Status
Recruiting
Facility Name
Alexandras General Hospital of Athens; Oncology Department
City
Athens
ZIP/Postal Code
115 28
Country
Greece
Individual Site Status
Recruiting
Facility Name
Metropolitan General Hospital
City
Cholargos
ZIP/Postal Code
155 62
Country
Greece
Individual Site Status
Recruiting
Facility Name
University General Hospital of Heraklion
City
Crete
ZIP/Postal Code
711 10
Country
Greece
Individual Site Status
Recruiting
Facility Name
University Hospital of Larissa;Department of Medical Oncology
City
Larissa
ZIP/Postal Code
411 10
Country
Greece
Individual Site Status
Recruiting
Facility Name
Metropolitan Hospital; 2Nd Oncology Clinic
City
Piraeus
ZIP/Postal Code
185 47
Country
Greece
Individual Site Status
Recruiting
Facility Name
Euromedical General Clinic of Thessaloniki; Oncology Department
City
Thessaloniki
ZIP/Postal Code
546 45
Country
Greece
Individual Site Status
Recruiting
Facility Name
Queen Mary Hospital; Surgery
City
Hong Kong
ZIP/Postal Code
852
Country
Hong Kong
Individual Site Status
Recruiting
Facility Name
Pamela Youde Nethersole Eastern Hospital; Clinical Oncology
City
Hong Kong
Country
Hong Kong
Individual Site Status
Recruiting
Facility Name
Tuen Mun Hospital; Clinical Oncology
City
Hong Kong
Country
Hong Kong
Individual Site Status
Recruiting
Facility Name
Budapesti Szent Margit Korhaz; Onkologia Osztaly
City
Budapest
ZIP/Postal Code
1032
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Eszak-Pesti Centrumkorhaz - Honvedkorhaz; Podmaniczky utcai telephely
City
Budapest
ZIP/Postal Code
1062
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Orszagos Onkologiai Intezet; B Belgyogyaszati Osztaly
City
Budapest
ZIP/Postal Code
1122
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Debreceni Egyetem Klinikai Kozpont ; Department of Oncology
City
Debrecen
ZIP/Postal Code
4032
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Borsod-Abauj-Zemplen Megyei Korhaz Es Egyetemi Oktato Korhaz; Onkologiai Osztaly
City
Miskolc
ZIP/Postal Code
3501
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Rajiv Gandhi Cancer Institute & Research Center
City
New Delhi
State/Province
Delhi
ZIP/Postal Code
110085
Country
India
Individual Site Status
Active, not recruiting
Facility Name
Max Super Speciality Hospital; Medical Oncology
City
North WEST Delhi
State/Province
Delhi
ZIP/Postal Code
110088
Country
India
Individual Site Status
Recruiting
Facility Name
Hemato Oncology Clinic Ahmedabad Pvt Ltd
City
Ahmadabad
State/Province
Gujarat
ZIP/Postal Code
380054
Country
India
Individual Site Status
Recruiting
Facility Name
Manipal Hospital; Department of Oncology
City
Bangalore
State/Province
Karnataka
ZIP/Postal Code
560017
Country
India
Individual Site Status
Recruiting
Facility Name
Tata Memorial Hospital; Dept of Medical Oncology
City
Mumbai
State/Province
Maharashtra
ZIP/Postal Code
400012
Country
India
Individual Site Status
Active, not recruiting
Facility Name
HCG Manavata Cancer Centre
City
Nashik
State/Province
Maharashtra
ZIP/Postal Code
422002
Country
India
Individual Site Status
Recruiting
Facility Name
Sahyadri Super Specialty Hospital Hadapsar
City
Pune
State/Province
Maharashtra
ZIP/Postal Code
411028
Country
India
Individual Site Status
Recruiting
Facility Name
Christian Med Clg & Hspt
City
Ratnagiri Kilminnal
State/Province
Tamil NADU
ZIP/Postal Code
632517
Country
India
Individual Site Status
Active, not recruiting
Facility Name
TATA Medical Centre; Medical Oncology
City
Kolkata
State/Province
WEST Bengal
ZIP/Postal Code
700156
Country
India
Individual Site Status
Recruiting
Facility Name
AORN'S.G.Moscati; Oncologia
City
Avellino
State/Province
Campania
ZIP/Postal Code
83100
Country
Italy
Individual Site Status
Active, not recruiting
Facility Name
U.O.C. Oncologia Medica Senologica
City
Napoli
State/Province
Campania
ZIP/Postal Code
80131
Country
Italy
Individual Site Status
Recruiting
Facility Name
Università degli Studi Federico II; Clinica di Oncologia Medica
City
Napoli
State/Province
Campania
ZIP/Postal Code
80131
Country
Italy
Individual Site Status
Active, not recruiting
Facility Name
Policlinico S.Orsola-Malpighi; Istituto Oncologia R. Addarii
City
Bologna
State/Province
Emilia-Romagna
ZIP/Postal Code
40138
Country
Italy
Individual Site Status
Withdrawn
Facility Name
A.O. Universitaria Policlinico Di Modena; Oncologia
City
Modena
State/Province
Emilia-Romagna
ZIP/Postal Code
41124
Country
Italy
Individual Site Status
Recruiting
Facility Name
Irccs Centro Di Riferimento Oncologico (CRO)
City
Aviano
State/Province
Friuli-Venezia Giulia
ZIP/Postal Code
33081
Country
Italy
Individual Site Status
Recruiting
Facility Name
ASU FC S. M. DELLA MISERICORDIA; Oncologia
City
Udine
State/Province
Friuli-Venezia Giulia
ZIP/Postal Code
33100
Country
Italy
Individual Site Status
Withdrawn
Facility Name
Policlinico Universitario Agostino Gemelli
City
Roma
State/Province
Lazio
ZIP/Postal Code
00168
Country
Italy
Individual Site Status
Recruiting
Facility Name
ASST DEGLI SPEDALI CIVILI DI BRESCIA; Oncologia Medica
City
Brescia
State/Province
Lombardia
ZIP/Postal Code
25123
Country
Italy
Individual Site Status
Recruiting
Facility Name
Ospedale San Raffaele; Medical Oncology
City
Milano
State/Province
Lombardia
ZIP/Postal Code
20132
Country
Italy
Individual Site Status
Recruiting
Facility Name
Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 1
City
Milano
State/Province
Lombardia
ZIP/Postal Code
20133
Country
Italy
Individual Site Status
Recruiting
Facility Name
Ospedale Civile - Livorno
City
Livorno
State/Province
Toscana
ZIP/Postal Code
57124
Country
Italy
Individual Site Status
Recruiting
Facility Name
Azlenda Ospendaliero-Universitaria Pisana; C.O. Oncologia 2
City
Pisa
State/Province
Toscana
ZIP/Postal Code
56100
Country
Italy
Individual Site Status
Recruiting
Facility Name
University of Eastern Piedmont - Maggiore della Carità University Hospital
City
Novara
State/Province
Umbria
ZIP/Postal Code
28100
Country
Italy
Individual Site Status
Recruiting
Facility Name
IRCCS Istituto Oncologico Veneto (IOV); Oncologia Medica Seconda
City
Padova
State/Province
Veneto
ZIP/Postal Code
35128
Country
Italy
Individual Site Status
Withdrawn
Facility Name
International Cancer Institute (ICI)
City
Eldoret
ZIP/Postal Code
30100
Country
Kenya
Individual Site Status
Recruiting
Facility Name
Aga Khan University Hospital
City
Nairobi
ZIP/Postal Code
00100
Country
Kenya
Individual Site Status
Recruiting
Facility Name
Kyungpook National University Medical Center
City
Daegu
ZIP/Postal Code
41404
Country
Korea, Republic of
Individual Site Status
Active, not recruiting
Facility Name
National Cancer Center
City
Goyang-si
ZIP/Postal Code
10408
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Seoul National University Bundang Hospital
City
Seongnam-si
ZIP/Postal Code
463-707
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Korea University Anam Hospital
City
Seoul
ZIP/Postal Code
02841
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Seoul National University Hospital
City
Seoul
ZIP/Postal Code
03080
Country
Korea, Republic of
Individual Site Status
Active, not recruiting
Facility Name
Severance Hospital, Yonsei University Health System
City
Seoul
ZIP/Postal Code
03722
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Asan Medical Center
City
Seoul
ZIP/Postal Code
05505
Country
Korea, Republic of
Individual Site Status
Active, not recruiting
Facility Name
Gangnam Severance Hospital
City
Seoul
ZIP/Postal Code
06273
Country
Korea, Republic of
Individual Site Status
Active, not recruiting
Facility Name
Samsung Medical Center
City
Seoul
ZIP/Postal Code
06351
Country
Korea, Republic of
Individual Site Status
Active, not recruiting
Facility Name
Seoul St Mary's Hospital
City
Seoul
ZIP/Postal Code
06591
Country
Korea, Republic of
Individual Site Status
Active, not recruiting
Facility Name
Korea University Guro Hospital
City
Seoul
ZIP/Postal Code
08308
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Investigacion Oncofarmaceutica
City
La Paz
State/Province
BAJA California SUR
ZIP/Postal Code
23040
Country
Mexico
Individual Site Status
Recruiting
Facility Name
Health Pharma Professional Research
City
Cdmx
State/Province
Mexico CITY (federal District)
ZIP/Postal Code
03100
Country
Mexico
Individual Site Status
Active, not recruiting
Facility Name
Centro Medico Dalinde
City
Cdmx
State/Province
Mexico CITY (federal District)
ZIP/Postal Code
06760
Country
Mexico
Individual Site Status
Recruiting
Facility Name
Instituto Nacional De Cancerologia; Oncology; Tumores Mamarios
City
Distrito Federal
State/Province
Mexico CITY (federal District)
ZIP/Postal Code
14000
Country
Mexico
Individual Site Status
Recruiting
Facility Name
Filios Alta Medicina
City
Monterrey
State/Province
Nuevo LEON
ZIP/Postal Code
64460
Country
Mexico
Individual Site Status
Recruiting
Facility Name
Centro de Investigacion Clinica de Oaxaca
City
Oaxaca de Juárez
State/Province
Oaxaca
ZIP/Postal Code
68020
Country
Mexico
Individual Site Status
Recruiting
Facility Name
Auckland City Hospital, Cancer and Blood Research
City
Auckland
ZIP/Postal Code
1023
Country
New Zealand
Individual Site Status
Recruiting
Facility Name
Tauranga Hospital, Clinical Trials Unit; BOP Clinical School
City
Tauranga
ZIP/Postal Code
3112
Country
New Zealand
Individual Site Status
Recruiting
Facility Name
Bialostockie Centrum Onkologii; Oddzial Onkologii Klinicznej
City
Bialystok
ZIP/Postal Code
15-027
Country
Poland
Individual Site Status
Active, not recruiting
Facility Name
Uniwersyteckie Centrum Kliniczne; Klinika Onkologii i Radioterapii
City
Gda?sk
ZIP/Postal Code
80-214
Country
Poland
Individual Site Status
Recruiting
Facility Name
Narodowy Instytut Onkologii Odzia? w Gliwicach; Centrum Diagnostyki i Leczenia Chorób Piersi
City
Gliwice
ZIP/Postal Code
44-102
Country
Poland
Individual Site Status
Recruiting
Facility Name
Szpital Uniwersytecki w Krakowie, Oddzia? Kliniczny Kliniki Onkologii
City
Kraków
ZIP/Postal Code
30-688
Country
Poland
Individual Site Status
Active, not recruiting
Facility Name
Wielkopolskie Centrum Onkologii; Oddzial Chemioterapii
City
Poznan
ZIP/Postal Code
61-866
Country
Poland
Individual Site Status
Active, not recruiting
Facility Name
Centrum Onkologii Instytut im.M. Sklodowskiej-Curie; Klin. Nowot. Piersii i Chirurgii Rekonstruk
City
Warszawa
ZIP/Postal Code
02-781
Country
Poland
Individual Site Status
Active, not recruiting
Facility Name
Hospital CUF Tejo; Oncologia Médica e Hematologia
City
Lisboa
ZIP/Postal Code
1350-352
Country
Portugal
Individual Site Status
Recruiting
Facility Name
Hospital de Santa Maria; Servico de Oncologia Medica
City
Lisboa
ZIP/Postal Code
1649-035
Country
Portugal
Individual Site Status
Recruiting
Facility Name
Hospital Beatriz Angelo; Departamento de Oncologia
City
Loures
ZIP/Postal Code
2674-514
Country
Portugal
Individual Site Status
Recruiting
Facility Name
Centro Hospitalar do Porto ? Hospital de Santo António; Oncologia
City
Porto
ZIP/Postal Code
4099-001
Country
Portugal
Individual Site Status
Withdrawn
Facility Name
IPO do Porto; Servico de Oncologia Medica
City
Porto
ZIP/Postal Code
4200-072
Country
Portugal
Individual Site Status
Recruiting
Facility Name
Filantropia Clinical Hospital; Medical oncology
City
Bucuresti
ZIP/Postal Code
021164
Country
Romania
Individual Site Status
Recruiting
Facility Name
Prof.dr. Alexandru Trestioreanu, The Oncology Institute; Medical oncology I
City
Bucuresti
ZIP/Postal Code
022328
Country
Romania
Individual Site Status
Active, not recruiting
Facility Name
Amethyst Cluj; Medical Oncology
City
Cluj County
ZIP/Postal Code
407280
Country
Romania
Individual Site Status
Active, not recruiting
Facility Name
Cluj-Napoca Emergency Clinical County Hospital; Medical Oncology
City
Cluj-Napoca
ZIP/Postal Code
400006
Country
Romania
Individual Site Status
Recruiting
Facility Name
Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj-Napoca; Radioterapie I - Oncologie
City
Cluj-Napoca
ZIP/Postal Code
400015
Country
Romania
Individual Site Status
Active, not recruiting
Facility Name
Centrul de Oncologie Sfantul Nectarie
City
Craiova
ZIP/Postal Code
200347
Country
Romania
Individual Site Status
Active, not recruiting
Facility Name
Oncomed SRL
City
Timisoara
ZIP/Postal Code
300239
Country
Romania
Individual Site Status
Active, not recruiting
Facility Name
Republican Clinical Oncological Dispensary of the Ministry of Healthcare; Chemotherapy department
City
Kazan
State/Province
Karelija
ZIP/Postal Code
420029
Country
Russian Federation
Individual Site Status
Recruiting
Facility Name
Krasnoyarsk Regional Oncology Dispensary n.a. Krizhanovsky; Chemotherapy
City
Krasnoyarsk
State/Province
Krasnodar
ZIP/Postal Code
660133
Country
Russian Federation
Individual Site Status
Completed
Facility Name
Oncology Dispensary#1; Out-Patient Oncology Dept
City
Moscow
State/Province
Moskovskaja Oblast
ZIP/Postal Code
105005
Country
Russian Federation
Individual Site Status
Withdrawn
Facility Name
FSBI Russian Oncology Research Center n.a. Blokhin of MOH RF
City
Moscow
State/Province
Moskovskaja Oblast
ZIP/Postal Code
115478
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
MEDSI Clinical Hospital on Pyatnitsky Highway; Department of antitumor drug therapy
City
Moscow
State/Province
Moskovskaja Oblast
ZIP/Postal Code
143422
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
SBIH "Moscow Clinical Scientific and Practical Center named after A.S. Loginov of DHM"
City
Moskva
State/Province
Moskovskaja Oblast
ZIP/Postal Code
111123
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
Nizhny Novgorod Regional Clinical Oncology Center
City
Nizhny Novgorod
State/Province
Niznij Novgorod
ZIP/Postal Code
603126
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
S-Pb clinical scientific practical center of specialized kinds of medical care (oncological)
City
Saint-Petersburg
State/Province
Sankt Petersburg
ZIP/Postal Code
197758
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
Medical Clinic "AB Medical group"
City
Sankt-peterburg
State/Province
Sankt Petersburg
ZIP/Postal Code
196006
Country
Russian Federation
Individual Site Status
Recruiting
Facility Name
SBI of Healthcare Leningrad Regional Oncology Dispensary
City
St PETERBURG
State/Province
Sankt Petersburg
ZIP/Postal Code
191104
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
FSBI?National Medical Research Center of Oncology named after N.N.Petrov? MHRF
City
St Petersburg
State/Province
Sankt Petersburg
ZIP/Postal Code
197758
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
SBIH Kaluga Region Clinical Oncology Dispensary
City
Kaluga
ZIP/Postal Code
248007
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
LLC Medical and Sanitary Unit "Clinician"
City
Novosibirsk
ZIP/Postal Code
630099
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
SBI of Healthcare Samara Regional Clinical Oncology Dispensary
City
Samara
ZIP/Postal Code
443031
Country
Russian Federation
Individual Site Status
Withdrawn
Facility Name
Regional Oncology Dispensary
City
Tomsk
ZIP/Postal Code
634063
Country
Russian Federation
Individual Site Status
Recruiting
Facility Name
Regional Clinical Oncology Hospital
City
Yaroslavl
ZIP/Postal Code
150040
Country
Russian Federation
Individual Site Status
Active, not recruiting
Facility Name
National Cancer Centre; Medical Oncology
City
Singapore
ZIP/Postal Code
168583
Country
Singapore
Individual Site Status
Recruiting
Facility Name
Hospital General Universitario de Elche; Servicio de Oncologia
City
Elche
State/Province
Alicante
ZIP/Postal Code
03203
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia
City
Badalona
State/Province
Barcelona
ZIP/Postal Code
08916
Country
Spain
Individual Site Status
Recruiting
Facility Name
Corporacio Sanitaria Parc Tauli; Servicio de Oncologia
City
Sabadell
State/Province
Barcelona
ZIP/Postal Code
8208
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital de Jerez de la Frontera; Servicio de Oncologia
City
Jerez de La Frontera
State/Province
Cadiz
ZIP/Postal Code
11407
Country
Spain
Individual Site Status
Recruiting
Facility Name
Complejo Hospitalario Universitario A Coruña (CHUAC); Servicio de Oncologia
City
A Coruña
State/Province
LA Coruña
ZIP/Postal Code
15006
Country
Spain
Individual Site Status
Recruiting
Facility Name
Complejo Hospitalario Universitario de Santiago (CHUS) ; Servicio de Oncologia
City
Santiago de Compostela
State/Province
LA Coruña
ZIP/Postal Code
15706
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Quiron de Madrid; Servicio de Oncologia
City
Pozuelo de Alarcon
State/Province
Madrid
ZIP/Postal Code
28223
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Alvaro Cunqueiro; Servicio de Oncologia
City
Vigo
State/Province
Pontevedra
ZIP/Postal Code
36213
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario de Canarias;servicio de Oncologia
City
La Laguna
State/Province
Tenerife
ZIP/Postal Code
38320
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital de Basurto; Servicio de Oncologia
City
Bilbao
State/Province
Vizcaya
ZIP/Postal Code
48013
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital del Mar; Servicio de Oncologia
City
Barcelona
ZIP/Postal Code
08003
Country
Spain
Individual Site Status
Recruiting
Facility Name
Vall d?Hebron Institute of Oncology (VHIO), Barcelona
City
Barcelona
ZIP/Postal Code
08035
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Clinic Barcelona; Servicio de oncologia
City
Barcelona
ZIP/Postal Code
08036
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario Clínico San Cecilio; Servicio de oncologia
City
Granada
ZIP/Postal Code
18016
Country
Spain
Individual Site Status
Active, not recruiting
Facility Name
Hospital Juan Ramon Jimenez;Servicio de Oncologia
City
Huelva
ZIP/Postal Code
21005
Country
Spain
Individual Site Status
Recruiting
Facility Name
Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de Oncologia
City
Jaen
ZIP/Postal Code
23007
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital General Universitario Gregorio Marañon; Servicio de Oncologia
City
Madrid
ZIP/Postal Code
28007
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Ramon y Cajal; Servicio de Oncologia
City
Madrid
ZIP/Postal Code
28034
Country
Spain
Individual Site Status
Withdrawn
Facility Name
Hospital Clinico San Carlos; Servicio de Oncologia
City
Madrid
ZIP/Postal Code
28040
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario La Paz; Servicio de Oncologia
City
Madrid
ZIP/Postal Code
28046
Country
Spain
Individual Site Status
Withdrawn
Facility Name
Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia
City
Malaga
ZIP/Postal Code
29010
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Clinico Universitario de Salamanca; Servicio de Oncologia
City
Salamanca
ZIP/Postal Code
37007
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario Virgen Macarena; Servicio de Oncologia
City
Sevilla
ZIP/Postal Code
41009
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario Virgen del Rocio; Servicio de Oncologia
City
Sevilla
ZIP/Postal Code
41013
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Clínico Universitario de Valencia; Servicio de Oncología
City
Valencia
ZIP/Postal Code
46010
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario Dr. Peset; Servicio de Oncologia
City
Valencia
ZIP/Postal Code
46017
Country
Spain
Individual Site Status
Recruiting
Facility Name
Hospital Universitario Miguel Servet; Servicio Oncologia
City
Zaragoza
ZIP/Postal Code
50009
Country
Spain
Individual Site Status
Recruiting
Facility Name
China Medical University Hospital; Surgery
City
Taichung
ZIP/Postal Code
404
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
National Cheng Kung Uni Hospital; Dept of Hematology and Oncology
City
Tainan
ZIP/Postal Code
704
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
National Taiwan University Hospital ; Dept of Surgery & Hepatitis Research Center
City
Taipei 100
ZIP/Postal Code
100
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
Taipei Veterans General Hospital; Department of Clinical Trial Pharmacy
City
Taipei
ZIP/Postal Code
00112
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
Mackay Memorial Hospital; Dept of Surgery
City
Taipei
ZIP/Postal Code
104
Country
Taiwan
Individual Site Status
Recruiting
Facility Name
Chulalongkorn Hospital; Medical Oncology
City
Bangkok
ZIP/Postal Code
10330
Country
Thailand
Individual Site Status
Recruiting
Facility Name
Ramathibodi Hospital; Dept of Med.-Div. of Med. Onc
City
Bangkok
ZIP/Postal Code
10400
Country
Thailand
Individual Site Status
Active, not recruiting
Facility Name
Srinagarind Hospital; Department of Surgery
City
Khon Kaen
ZIP/Postal Code
40002
Country
Thailand
Individual Site Status
Recruiting
Facility Name
Songklanagarind Hospital; Department of Surgery
City
Songkla
ZIP/Postal Code
90110
Country
Thailand
Individual Site Status
Recruiting
Facility Name
Adana Baskent University Hospital; Medical Oncology
City
Adana
ZIP/Postal Code
01120
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Hacettepe University Medical Faculty
City
Ankara
ZIP/Postal Code
06100
Country
Turkey
Individual Site Status
Active, not recruiting
Facility Name
Ankara Bilkent City Hospital
City
Ankara
ZIP/Postal Code
06490
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Gazi University Medical Faculty, Oncology Hospital
City
Ankara
ZIP/Postal Code
06500
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Memorial Ankara Hastanesi
City
Ankara
ZIP/Postal Code
06520
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Antalya Training and Research Hospital ; Oncology Department
City
Antalya
ZIP/Postal Code
07100
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Ege University Medical Faculty; Medical Oncology Department
City
Bornova, ?zm?r
ZIP/Postal Code
35100
Country
Turkey
Individual Site Status
Active, not recruiting
Facility Name
Dicle University Faculty of Medicine
City
Diyarbakir
ZIP/Postal Code
21280
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi
City
Edirne
ZIP/Postal Code
22030
Country
Turkey
Individual Site Status
Active, not recruiting
Facility Name
Istanbul Faculty of Medicine
City
Istanbul
ZIP/Postal Code
34093
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Istanbul University Cerrahpasa Faculty of Medicine
City
Istanbul
ZIP/Postal Code
34098
Country
Turkey
Individual Site Status
Active, not recruiting
Facility Name
Katip Celebi University Ataturk Training and Research Hospital; Oncology
City
Izmir
ZIP/Postal Code
35360
Country
Turkey
Individual Site Status
Active, not recruiting
Facility Name
Medeniyet University Goztepe Training and Research Hospital.
City
Kadiköy
ZIP/Postal Code
34722
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Inonu University Medical Faculty of Medicine; Medical Oncology Department
City
Malatya
ZIP/Postal Code
44280
Country
Turkey
Individual Site Status
Active, not recruiting
Facility Name
Medical Park Seyhan Hospital; Oncology Department
City
Seyhan
ZIP/Postal Code
01140
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Ac?badem Altunizade Hastanesi; Oncology
City
Üsküdar
ZIP/Postal Code
34662
Country
Turkey
Individual Site Status
Recruiting
Facility Name
Uganda Cancer Institute
City
Kampala
Country
Uganda
Individual Site Status
Recruiting
Facility Name
Uzhgorod Central City Clinical Hospital
City
Uzhhorod
State/Province
Katerynoslav Governorate
ZIP/Postal Code
88000
Country
Ukraine
Individual Site Status
Active, not recruiting
Facility Name
Municipal Noncommercial Institution Regional Center of Oncology
City
Kharkiv
State/Province
Kharkiv Governorate
ZIP/Postal Code
61070
Country
Ukraine
Individual Site Status
Recruiting
Facility Name
Municipal non profit enterprise of Sumy Regional Council Sumy Regional Clinical Oncology Disp
City
Sumy
State/Province
Kholm Governorate
ZIP/Postal Code
40005
Country
Ukraine
Individual Site Status
Recruiting
Facility Name
MI "Clinical Oncological Dispensary" of Dnipro Reg Council; chemotherapy department
City
Dnipro
State/Province
KIEV Governorate
ZIP/Postal Code
49100
Country
Ukraine
Individual Site Status
Withdrawn
Facility Name
Innovacia Cancer Center
City
Liutizh
State/Province
KIEV Governorate
ZIP/Postal Code
07352
Country
Ukraine
Individual Site Status
Recruiting
Facility Name
CI Dnipropetrovsk CMCH #4 of Dnipropetrovsk RC SI Dnipropetrovsk MA of MOHU Ch of Oncology and MR
City
Dnipropetrovsk
ZIP/Postal Code
49102
Country
Ukraine
Individual Site Status
Recruiting
Facility Name
Municipal Institution Kirovograd Regional Oncology Dispensary
City
Kirovograd
ZIP/Postal Code
25011
Country
Ukraine
Individual Site Status
Recruiting
Facility Name
Kyiv City Clinical Oncological Center
City
Kyiv
ZIP/Postal Code
03115
Country
Ukraine
Individual Site Status
Recruiting
Facility Name
Belfast City Hospital
City
Belfast
ZIP/Postal Code
BT9 7AB
Country
United Kingdom
Individual Site Status
Withdrawn
Facility Name
Blackpool Victoria Hospital
City
Blackpool
ZIP/Postal Code
FY3 8NR
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Bradford Royal Infirmary; Oncology Department
City
Bradford
ZIP/Postal Code
BD9 6RJ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Royal Sussex County Hospital
City
Brighton
ZIP/Postal Code
BN2 5BE
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
Addenbrookes Hospital
City
Cambridge
ZIP/Postal Code
CB2 0QQ
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
Velindre Cancer Centre; Clinical Trials Unit
City
Cardiff
ZIP/Postal Code
CF14 2TL
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Cheltenham General Hospital
City
Cheltenham
ZIP/Postal Code
GL53 7AN
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Royal Cornwall Hospital; Dept of Clinical Oncology
City
Cornwall
ZIP/Postal Code
TR1 3LQ
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
Hairmyres Hospital
City
East Kilbride
ZIP/Postal Code
G75 8RG
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
Raigmore Hospital
City
Inverness
ZIP/Postal Code
IV2 3UV
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
Barts & London School of Med; Medical Oncology
City
London
ZIP/Postal Code
EC1A 7BE
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
University College London Hospital
City
London
ZIP/Postal Code
N7 9NH
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Royal Free Hospital
City
London
ZIP/Postal Code
NW3 2QS
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Royal Marsden Hospital - London
City
London
ZIP/Postal Code
SW3 6JJ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Christie Hospital NHS Trust
City
Manchester
ZIP/Postal Code
M20 4BX
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Mount Vernon Cancer Centre
City
Northwood
ZIP/Postal Code
HA6 2RN
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
Nottingham City Hospital
City
Nottingham
ZIP/Postal Code
NG5 1PB
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
Royal Preston Hospital
City
Preston
ZIP/Postal Code
PR2 9HT
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Glan Clywd Hospital
City
Rhyl
ZIP/Postal Code
LL18 5UJ
Country
United Kingdom
Individual Site Status
Withdrawn
Facility Name
Musgrove Park Hospital
City
Somerset
ZIP/Postal Code
TA1 5DA
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Royal Marsden Hospital - Surrey
City
Surrey
ZIP/Postal Code
SM2 5PT
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Walsall Manor Hospital
City
Walsall
ZIP/Postal Code
WS2 9PS
Country
United Kingdom
Individual Site Status
Active, not recruiting
12. IPD Sharing Statement
Plan to Share IPD
Yes
IPD Sharing Plan Description
Qualified researchers may request access to individual patient level data through the clinical study data request platform (www.vivli.org). Further details on Roche's criteria for eligible studies are available here (https://vivli.org/ourmember/roche/). For further details on Roche's Global Policy on the Sharing of Clinical Information and how to request access to related clinical study documents, see here (https://www.roche.com/research_and_development/who_we_are_how_we_work/clinical_trials/our_commitment_to_data_sharing.htm).
Citations:
PubMed Identifier
36382554
Citation
Hurvitz SA, Bachelot T, Bianchini G, Harbeck N, Loi S, Park YH, Prat A, Gilham L, Boulet T, Gochitashvili N, Monturus E, Lambertini C, Nyawira B, Knott A, Restuccia E, Schmid P. ASTEFANIA: adjuvant ado-trastuzumab emtansine and atezolizumab for high-risk, HER2-positive breast cancer. Future Oncol. 2022 Oct;18(32):3563-3572. doi: 10.2217/fon-2022-0485. Epub 2022 Nov 16.
Results Reference
derived
Learn more about this trial
A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy
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