To Evaluate the Short-term and Long Term Efficacy of Acupuncture in Ocular and Oral Dryness Symptoms of Dry Eye Syndrome
Dry Eye Syndrome, Xerophthalmia
About this trial
This is an interventional treatment trial for Dry Eye Syndrome focused on measuring dry eye syndromes, Xerophthalmia, acupuncture, GB20, BL2, Oral microbiota
Eligibility Criteria
Dry eye syndrome
Inclusion Criteria:
- aged between 20 and 75 years
- Schirmer's test less than 10 mm/5 min
Exclusion Criteria:
- Pregnancy
- With eye inflammation or infectious eye disease
- Accepted operation of eye
Sjögren's syndrome
Inclusion Criteria:
- primary or secondary SS
- aged between 20 and 75 years
- fulfilled the 2002 American-European Consensus Criteria for SS (AECG)
- had no abnormal findings of immune, liver, kidney, or blood function evaluations.
Exclusion Criteria:
- a history of alcohol abuse, diabetes mellitus, or major life-threatening condition
- pregnancy or breastfeeding
- steroid pulse therapy within three months prior to the commencement of our study.
Sites / Locations
- Ching-Mao ChangRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Other
Other
Group GB20
Group GB20 plus BL2
Healthy control
Waiting list
Group GB20 will received acupuncture at acupoint GB20 twice a week 8 weeks for efficacy evaluation. And we could use the oral microbiota, Schirmer's test, Tear breakup time, 6-GSI, OSDI, TCM pattern, Traditional Chinese Medicine (TCM) tongue diagnosis, TCM pulse diagnosis, and TCM heart rate variability for this purpose.
Group GB20 plus BL2 will received acupuncture at acupoint GB20 plus BL2 twice a week 8 weeks for efficacy evaluation. And we could use the oral microbiota, Schirmer's test, Tear breakup time, 6-GSI, OSDI, TCM pattern, Traditional Chinese Medicine (TCM) tongue diagnosis, TCM pulse diagnosis, and TCM heart rate variability for this purpose.
Healthy control group will not received any treatment. And we could use the oral microbiota, TCM pattern, Traditional Chinese Medicine (TCM) tongue diagnosis, TCM pulse diagnosis, and TCM heart rate variability to find the difference with the comparison between the dry eye syndrome and healthy control.
Group Waiting list will not received any treatment. at acupoint GB20 plus BL2 twice a week 8 weeks for efficacy evaluation. And we could use the oral microbiota, Schirmer's test, Tear breakup time, 6-GSI, OSDI, TCM pattern, Traditional Chinese Medicine (TCM) tongue diagnosis, TCM pulse diagnosis, and TCM heart rate variability for this purpose.