Multisite Tissue Oxygenation Guided Perioperative Care in Cardiac Surgery (BOTTOMLINECS)
Brain Ischemia Hypoxia, Muscle; Ischemic, Muscle Hypoxia
About this trial
This is an interventional prevention trial for Brain Ischemia Hypoxia focused on measuring Cerebral Tissue Oxygen Saturation, Muscular Tissue Oxygen Saturation, Cardiac Surgery, Complications, Multisite Tissue Oxygenation Monitoring
Eligibility Criteria
Inclusion Criteria:
- Patients aged ≥ 60 years scheduled for elective off-pump CABG.
Exclusion Criteria:
- Inability or refusal to provide consent of participation
- Preoperative requirement of respiratory support (intubation, CPAP or BiPAP, or high-flow oxygen (>10 L/min))
- Preoperative requirement of external cardiac assist device
- Urgent or emergent surgery
- Patients expected to die within 30 days of randomization
Sites / Locations
- Tianjin Chest HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Multisite tissue oxygenation monitoring-guided care
Usual care
Details are as follows. • Monitoring: SctO2 monitored using two probes placed on left and right forehead. SstO2 monitored using one probe placed over the forearm brachioradialis muscle on the arm not used for non-invasive blood pressure monitoring. • Baseline: The first baseline is measured 12-48 hours before surgery, with the patient supine, awake, calm, eyes closed, and breathing room air or oxygen that is equivalent to the home oxygen rate for patients using home oxygen. Goals: Maintain both SctO2 and SstO2 within 90-110% of the baseline level. Trigger of intervention: SctO2/SstO2 outside of the 90-110% baseline range. Diagnosis: Care team: The caregivers providing SctO2/SstO2-guided care will be trained and given the opportunity to use the intervention protocol in at least 20 patients before the formal study. Treatments: Refer to the algorithm to restore SctO2/SstO2 within 90-110% baseline range.
Patients in the control group will be managed by clinical staff according to usual care. Patients in this group will be monitored using the same tissue oximeter used in the intervention group; however, the screen will be covered by an opaque cloth to prohibit the care givers seeing the monitoring data. The same baseline measurements will be performed in patients allocated to the usual care group.