Effects of Vitamin D Supplementation on Depression and Inflammatory Markers
Major Depression, Vitamin D Deficiency
About this trial
This is an interventional health services research trial for Major Depression
Eligibility Criteria
Inclusion Criteria:
- 1.patients who attend psychiatric outpatient clinics or who are admitted to the psychiatric inpatient ward at the above sites.
- 2.clinical diagnosis of depression-related disorders and scores of HDRS-17 ≥ 10.
- 3.psychotropics have been kept unchanged for at least a month.
- 4.aged 10 to 24.
- 5.serum 25-hydroxycholecalciferol (25-OH-D) levels lower than 20 ng/ml.
Exclusion Criteria:
1.endocrine disorders
- including diabetes
- thyroid
- parathyroid disorder.
2.serious neurological disorders
- epilepsy
- severe traumatic brain injury
- neurodegenerative conditions
- 3.liver disease
- 4.kidney disease
- 5.heart disease
- 6.other serious health conditions.
7.severe mental disorders
- Organic mental disorders
- Alcohol or substance use disorders active within 3 months
- Schizophrenia
- Delusional disorder
- Psychotic disorders not elsewhere classified.
- Bipolar disorder.
- Autistic spectrum disorder.
- Anorexia nervosa.
- Mental retardation with IQ less than 70.
- High violence or suicide risk.
8.Patients use drugs or herbals interfering with vitamin D metabolisms
- phenobarbital
- phenytoin
- anti-tuberculosis drugs
- thiazide diuretics.
- 9.Pregnant or expect to be pregnant during study participation.
Sites / Locations
- MacKay Memorial HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
No Intervention
Experimental
No Intervention
Vit D Group (randomized)
Control Group (randomized)
Preference Vit D Group (non-randomized)
Preference no Vit D Group (non-randomized)
Subjects will be randomly assigned to receive a daily vitamin D supplementation (4800IU daily) for 8 weeks
Subjects will be randomly assigned to receive a placebo for 8 weeks.
Subjects with a strong preference to receive a daily vitamin D supplementation (4800IU daily) for 8 weeks.
Subjects with a strong preference to receive usual care (not receiving vitamin D supplements) for 8 weeks.