The Impact of Energy Intake and Short-term Disuse on Muscle Protein Synthesis Rates and Skeletal Muscle Mass in Middle-aged Adults. (PIE)
Muscle Atrophy, Aging, Energy Malnutrition Protein
About this trial
This is an interventional basic science trial for Muscle Atrophy focused on measuring Muscle protein synthesis, Ageing, Dietary protein, Disuse
Eligibility Criteria
Inclusion Criteria:
Age 35-65 Healthy Non-smoker Recreationally active
Exclusion Criteria:
Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes) Any diagnosed cardiovascular disease or hypertension Elevated blood pressure at the time of screening. (An average systolic blood pressure reading of ≥150mmHg over two or more measurements and an average diastolic blood pressure of ≥90mmHg over two or more measurements.) Chronic use of diabetic medication. A personal or family history of epilepsy, seizures or schizophrenia. Allergic to mycoprotein / Quorn, penicillin, or cow's milk. Any musculoskeletal injury that may impair their use of crutches. Any diagnosed severe digestive illness. Any diagnosed severe autoimmune disease. Any diagnosed cancer. Any metal fragments in the eyes, a pacemaker, or metal implants in the body that preclude MRI scanning.
Sites / Locations
- Sport & Health Sciences University of ExeterRecruiting
- University of Exeter, Sports & Health Sciences, College of Life & Environmental SciencesRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
Hypocaloric
Energy Balance
Hypercaloric
Participants placed in energy restriction.
Participants placed in energy balance.
Participants placed in energy surplus.