NR Supplementation and Exercise
Overweight and Obesity, Aging, Type 2 Diabetes

About this trial
This is an interventional prevention trial for Overweight and Obesity focused on measuring exercise, NR supplementation, NAD metabolism
Eligibility Criteria
Inclusion Criteria:
- Participants are able to provide signed and dated written informed consent prior to any study specific procedures
- Aged ≥ 65 and ≤ 80 years
- Body mass index (BMI) 25 - 35 kg/m2
- Stable dietary habits (no weight loss or gain > 5 kg in the past 3 months)
- No signs of active cardiovascular disease, liver or kidney malfunction
Exclusion Criteria:
- Type 2 diabetes
- Patients with congestive heart failure and and/or severe renal and or liver insufficiency
- Uncontrolled hypertension
- Any contra-indication for MRI scanning
- Alcohol consumption of >3 servings per day for man and >2 servings per day for woman
- Smoking
- Unstable body weight (weight gain or loss > 5kg in the last 3 months)
- Engagement in structured exercise activities > 2 hours a week
- Previous enrolment in a clinical study with an investigational product during the last 3 months or as judged by the Investigator which would possibly hamper our study results
- Medication use known to hamper subject's safety during the study procedures
- Subjects who do not want to be informed about unexpected medical findings
- Use of food supplements containing NR or Resveratrol (similar working mechanisms)
Sites / Locations
- Maastricht University
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Exercise + NR
Exercise + Placebo
Participants will be asked to take two pills of NR (250mg/pill) twice daily (a total of 4 pills/day; 1000mg/day), for 40 days. During days 17-38 of the NR intervention, participants will perform a 3-weeks supervised exercise training program with four ~30 min exercise sessions per week (two endurance session on a bike at 70%Wmax and two high intensity interval (HIIT) sessions. To assess the outcomes, participants will undergo three test days before the start of the NR supplementation and repeat these three test days at the end (day 38-40) of NR supplementation.
Participants will be asked to take two pills of placebo, twice daily (a total of 4 pills/day), for 40 days. During days 17-38 of the intervention, participants will perform a 3-weeks supervised exercise training program with four ~30 min exercise sessions per week (two endurance session on a bike at 70%Wmax and two high intensity interval (HIIT) sessions. To assess the outcomes, participants will undergo three test days before the start of the NR supplementation and repeat these three test days at the end (day 38-40) of the placebo supplementation.