nHFOV Versus Invasive Conventional Ventilation for Preterm Neonates With Respiratory Distress Syndrome (nHFOV)
Respiratory Distress Syndrome in Premature Infant
About this trial
This is an interventional treatment trial for Respiratory Distress Syndrome in Premature Infant focused on measuring nHFOV, RDS, CPAP, Respiratory failure, Respiratory support
Eligibility Criteria
Inclusion Criteria:
- Inborn Preterm Neonates 26-34 weeks gestation admitted to NICU with diagnosis of RDS
- Babies who were initially started on High Flow Oxygen Therapy/nCPAP but unable to maintain saturation > 90% on fio2 of 40% in 1st 6 hours of life.
- Capillary PCO2 of > 70 or arterial PCO2 > 65 on two repeated sampling within 4 hours
- Neonates whose parents consented to participate.
Exclusion Criteria:
- All preterm babies who are below < 26 weeks above the 34 weeks of gestation
- Preterm neonates (26-34 weeks) with diagnosis of RDS requiring endotracheal intubation within Labor room/Operation Theater or within 1st hour of life for respiratory support.
- Preterm Neonates with the gestational age of 26-34 weeks, diagnosed as congenital pneumonia or sepsis.
- Patient with poor respiratory drive due to any reason neurological or central causes
- Diaphragmatic hernia or any other thoracic anomaly
- Pleural effusion unilateral or bilateral
- Congenital cystic pulmonary malformation.
- Neonates with underlying cyanotic heart disease.
- Neonates with acynotic heart disease causing pulmonary edema
- Neonates with cleft lip and cleft palate or any other surgical condition.
Sites / Locations
- Indus Hospital and Health Network
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Non-invasive High Frequency Oscillatory Ventilation
Conventional Invasive Ventilation
Preterm babies (26-28 weeks) born with respiratory distress will be initially started on nCPAP with setting of flow 6-8 liter, PEEP 5-6, FiO2 21-40%. If fio2 requirefment more than 40%, surfactant will be given in first 2 hours of birth. If baby fails on CPAP then will be switched to nHFOV with below mentioned settings. Preterm born babies 28-34 weeks gestation with RDS, respiratory support will be started on Heated Humidified High Flow Oxygen therapy or nCPAP, if that fails then baby will be switched to NHFOV with frequency of 5-20 (300-1200 breathe/min), Amplitude of 1-10, flow1-17.5 liter/min, fiO2 21-100% and integrated pressure triggered sensitivity option.
Preterm babies (26-28 weeks) born with respiratory distress will be initially started on nCPAP with setting of flow 6-8 liter, PEEP 5-6, FiO2 21-40%. If fio2 requirement more than 40%, surfactant will be given in first 2 hours of birth. If baby fails on CPAP then will be switched to nHFOV with below mentioned settings. Preterm born babies 28-34 weeks gestation with RDS, respiratory support will be started on Heated Humidified High Flow Oxygen therapy or nCPAP, if that fails then baby will be switched to invasive ventilation through endotracheal tube, mode will be selected as Synchronized Intermittent Mandatory ventilation (SIMV) with rate of 25-60 breath/min, flow of 8 liter, positive inspiratory pressure (PIP) of 14-25, Positive end expiratory pressure (PEEP) 4-5, fio2 of 21-40.