Serious Game-based Interventions in Patients With Mild Cognitive Impairment Outside the Clinic

Towards the Development of a Mobile-health Technology Designed to Encourage the Use of Serious Game-based Interventions in Patients With Mild Cognitive Impairment Outside the Clinic

This study will evaluate the therapeutic efficacy of Neuro-World cognitive training games (Woorisoft, S. Korea) in patients with mild cognitive impairment.

This study will be a cross-over randomized controlled trial. Fifty participants will be enrolled and randomly assigned to group A or group B. Group A will self-administer Neuro-World cognitive training games for 30 minutes a day, twice a week for 12 weeks in the home setting (i.e., intervention period). For the following 12 weeks, the participants will not engage in any therapist-supervised cognitive therapies (i.e., no-intervention period). Group B will not engage in any therapist-supervised cognitive therapies (i.e., no-intervention period). For the following 12 weeks, the participants will self-administer Neuro-World cognitive training games for 30 minutes a day, twice a week in the home setting (i.e., intervention period). All the participants in both groups will receive phone calls twice a week to 1) provide feedback on their adherence to Neuro-World cognitive training (during the intervention period) and 2) learn any significant changes in the level of their daily activities (during the no-intervention period and the intervention period).

Study participants play Neuro-World 30 minutes per day, twice a week for 12 weeks in your home settings (24 times).

Neuro-World is a collection of six games that are developed for cognitive training that focuses on memory and attention.

Alzheimer's Disease Cooperative Study/Activities of Daily Living scale adapted for mild cognitive impairment patients (ADCS/MCI/ADL24)

ADCS/MCI/ADL24 scores range between 0 and 69. Higher scores indicate greater levels of performance in activities of daily living.

Inclusion Criteria: Seventeen points or greater and smaller than twenty-six points on the Montreal Cognitive Assessment (MoCA) Fifty-five years old and above Minimal technological literacy (i.e. ability to use a tablet independently) Having a computer for online videoconferencing-based communication (necessary for online cognitive assessments) Exclusion Criteria: Confounding neurological and psychiatric disorders History of traumatic brain injury Clinically known hearing or vision impairment Severe upper-limb motor impairments that could impact the use of mobile devices Clinical presentations suggestive of dementia with Lewy bodies, progressive supranuclear palsy, multiple system atrophy, or vascular parkinsonism Diagnosis of dementia Major depression Any significant upper-limb impairment that could affect tablet use Participation in any other therapist-supervised cognitive training