Efficacy and Safety of Losartan/Chlorthalidone vs Losartan/Hydrochlorothiazide in Essential Arterial Hypertension

This is an interventional treatment trial for Essential Arterial Hypertension focused on measuring Hypertension, Blood pressure, Diuretic, Losartan, Chlorthalidone Read More

Inclusion Criteria:

• Any sex.
• That they agree to participate in the study and give their informed consent in writing.
• Age between 18 and 65 years old at the beginning of the study.
• Patients with essential arterial hypertension with BP ≥140 / 90 mmHg and <180/110 mmHg.
• Women of childbearing potential using a contraceptive method (barrier, oral hormonal, injectable, subdermal), menopausal or surgically sterile.

Exclusion Criteria:

• The drug is contraindicated for medical reasons.
• Glomerular filtration rate ≤30 ml / min x 1.73 m2.
• Hypersensitivity to any of the components of the formula or other sulfonamides.
• Patients treated with other diuretics.
• Patient with a history of vascular disease (cerebrovascular disease, acute coronary syndrome, etc.) and acute renal failure in the last 6 months.
• Patient with severe complications of type 2 diabetes mellitus (Ketoacidosis or hyperosmolar nonketotic coma).
• Patients participating in another clinical study involving an investigational treatment or participated in one in the previous 4 weeks.
• Positive pregnancy test, women who are pregnant, breastfeeding or planning a pregnancy while conducting the study.
• Oncological patients (except basal cell skin cancer) or with serious diseases that, in the opinion of the investigator, have a serious prognosis or a life expectancy of less than 1 year, as well as mental illnesses.
• Patients diagnosed with gout.
• Patients whose participation in the study may be influenced (employment relationship with the research center or sponsor, inmates, etc.).