The Role of 68-Gallium-DOTATATE-PET/CT in the Imaging of Metastatic Thyroid Cancer
Metastic Thyroid Cancer
About this trial
This is an interventional diagnostic trial for Metastic Thyroid Cancer focused on measuring Thyroid Cancer, Metastases, Ga68-DOTATATE, Somatostatin Receptors, Positron Emission Tomography
Eligibility Criteria
- INCLUSION CRITERIA:
Patients with HTC, DTC, and MTC will be identified by the investigators. The potential candidates for the study will be screened for eligibility to participate in the study and invited to sign the Research 68Gallium-DOTATATE PET/CT imaging informed consent form
In order to be eligible to participate in this study, an individual with DTC (including HTC) must meet all of the following criteria:
- Male or female, aged >=18 years.
Patients with established thyroid cancer diagnosis presenting with either:
- Locally advanced or distant metastases, which are RAI-non-avid based on the or diagnostic or post-treatment whole body scan (WBS) OR
- Patients with RAI-non-responsive disease, who have the evidence of disease progression defined by RECIST criteria after therapy with RAI.
In order to be eligible to participate in this study, an individual with MTC must meet all of the following criteria:
- Male or female, aged >=18 years.
- Patients with locally advanced or metastatic MTC or patients suspected of locally advanced or metastatic MTC with calcitonin level > 500 pg/mL.
EXCLUSION CRITERIA:
Subjects with either HTC, DTC, or MTC who meet any of the following criteria will be excluded from participation in this study:
- Pregnancy or lactation
- Serious underlying medical conditions that restrict diagnostic testing or therapy such as renal failure, congestive cardiac failure or active coexisting non-thyroid carcinoma;
- Patients unable to give informed consent.
Sites / Locations
- National Institutes of Health Clinical CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
Differentiated thyroid cancer (DTC)
Hurthle cell thyroid cancer (HTC)
Medullary thyroid cancer (MTC)
Patients with DTC but not HTC
Molecularly and histologically unique subtype of DTC - Hurthle cell thyroid cancer (HTC),
Patients with metastatic thyroid cancer of neuroendocrine origin - medullary thyroid cancer (MTC)