Mechanical Bowel Prep Randomized Study
Colorectal Surgery
About this trial
This is an interventional other trial for Colorectal Surgery focused on measuring Surgical Site Infection, Mechanical Bowel Preparation, Randomized Controlled Trial
Eligibility Criteria
Inclusion Criteria:
- undergoing elective colon surgery for benign or malignant disease
- over the age of 18 years
- provides informed consent.
Exclusion Criteria:
- known anaphylaxis to neomycin or metronidazole
- pregnancy or lactation
- chronic renal failure (serum creatinine > 220 umol/L).
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Group A: IV and Oral antibiotics (IVA+OA)
Group B: IV antibiotics, MBP and oral antibiotics (IVA+MBP+OA)
Patients will receive cefazolin 2g IV and metronidazole 500 mg IV administered by the anesthesiologist within 60 minutes prior to the skin incision on the day of surgery. Standardized re-dosing of cefazolin 2g IV will occur every 4 hours and metronidazole 500 mg IV will occur every 8 hours during the surgical procedure. Following surgery, no further IVA will be given for SSI prophylaxis. In addition, patients will self-administer 1g neomycin and 1g metronidazole orally at 1500, 1700 and 2300 hours the day before surgery. Following this, they will not receive any further OAs for SSI prophylaxis.
Patients will receive IVA and OA per Group A. In addition, patients will stay on clear fluids and self-administer a 2L polyethylene glycol MBP orally, between 1500 and 2300 hours on the day before surgery.