Associations of Combinations of Single-nucleotide Polymorphisms in Women With Premature Ovarian Failure
Primary Ovarian Insufficiency, Cardiovascular Diseases, Menopause, Premature
About this trial
This is an interventional diagnostic trial for Primary Ovarian Insufficiency focused on measuring premature ovarian failure, hypoestrogenism, artificial menopause, cardiovascular disease, chronic non-infectious disease, cardiovascular outcomes, coronary heart disease, pulmonary embolism, cardiac arrhythmias, heart rhythm disturbances, single nucleotide polymorphisms
Eligibility Criteria
Inclusion Criteria:
- women under 45 years old
- presence of premature ovarian insufficiency in the medical history
Exclusion Criteria:
- male gender
- age over 45 years
Sites / Locations
- Sergey Vladimirovich Lopukhov
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Study of single-nucleotide polymorphisms in women diagnosed with premature ovarian failure
Study of single-nucleotide polymorphisms in a control group of healthy women
Study of genes affecting single nucleotide polymorphisms: Reninangiotensin-aldosterone system (AGT, ACE), endothelial dysfunction (NOS3, EDN1), thrombosis-associated (ITGB3, ITGA2, FGB, GPIBA, SERPINE PAI1), proinflammatory (CRP, IL17A, IL2, IL10 1, IL10 2, TNFα, CRP 4, IL6, TLR2, TLR3, TLR4, TLR6, TLR9) in the study group of women diagnosed with premature ovarian failure.
Study of genes affecting single nucleotide polymorphisms: Reninangiotensin-aldosterone system (AGT, ACE), endothelial dysfunction (NOS3, EDN1), thrombosis-associated (ITGB3, ITGA2, FGB, GPIBA, SERPINE PAI1), pro-inflammatory (CRP, IL17A, IL2, IL10 1, IL10 2, TNFα, CRP 4, IL6, TLR2, TLR3, TLR4, TLR6, TLR9) in a control group of healthy women .