Characterization of Hamstring and Quadriceps Neuromuscular Fatigue After Soccer Game - Clinical Trial for Neuromuscular Fatigue | NCT04943510

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Primary Purpose

Status

Recruiting

Phase

Phase 2

Locations

France

Study Type

Interventional

Intervention

Physical exercices

About this trial

This is an interventional basic science trial for Neuromuscular Fatigue focused on measuring Hamstring, Neuromuscular fatigue, Soccer, Performance

Eligibility Criteria

16 Years - 40 Years (Child, Adult)MaleAccepts Healthy Volunteers

Inclusion Criteria:

male
age limits: minimum: 16 ; maximum: 40 years old
to be a soccer player, licensed to the French Football Federation
affiliation to the social health insurance scheme
signing an informed consent form

Exclusion Criteria:

impossibility to give the subject enlightened information (subject in emergency situation, difficulties in understanding the study, …)
subject under the protection of justice
subject under guardianship or curatorship
lower limbs musculotendinous or articular problems
smoker or having been a smoker in the last 5 years
subject wearing a pacemaker
drug treatment in progress and impossibility to stop it within 7 days before the beginning of the study.

Sites / Locations

Hopitaux Universitaires de StrasbourgRecruiting

Arms of the Study

Arm 1

Arm Type

Experimental

Arm Label

Physical exercices arm

Arm Description

three randomizations will be used to determine the order of the tests that will be proposed to the subjects: on the one hand for the exercise modalities (match, anaerobic, aerobic) and, on the other hand, for the exercise modalities included in the anaerobic and aerobic exercise families: Anaerobic agility / anaerobic - linear sprints Aerobic - shuttle / aerobic - linear

Outcomes

Primary Outcome Measures

Difference in maximal isometric hamstring strength before and immediately after exercise (i.e., pre vs. immediate post exercise) expressed as a percentage (%).

Secondary Outcome Measures

Relative difference (in %) in maximum isometric hamstring strength before and after exercise (i.e., pre- vs. post-exercise), relative to pre-exercise strength across different test types.

Relative difference (in %) in maximal isometric quadriceps strength before and after exercise (i.e., pre vs. post exercise), related to preexercise strength according to the different types of tests.

Relative difference (%) in maximum isometric hamstring and quadriceps strength for each test type at the different times of interest.

Difference in pre- and post-exercise (i.e., pre- vs. post-exercise) hamstring potentiated jerk amplitude (N) relative to pre-exercise amplitude by event type at different times of interest.

Difference in pre- and post-exercise (i.e., pre- vs. post-exercise) potentiated jerk amplitude (N) of the quadriceps, relative to pre-exercise amplitude, by test type at different times of interest.

Difference in amplitude of the potentiated jerk (N) before and after exercise, related to the preexercise amplitude according to the muscle involved (hamstrings or quadriceps) and the type of test at different times of interest.

Difference in the level of voluntary hamstring activation, expressed in newtons (N), before and after exercise, related to the pre-exercise action level, according to the type of test at different times of interest.

Difference in the level of voluntary quadriceps activation, expressed in newtons (N), before and after exercise, related to the pre-exercise action level, according to the type of test at different times of interest.

Difference in the level of voluntary action before and after exercise, related to the level of action before exercise, according to the muscle involved (hamstrings or quadriceps) and the type of test at different times of interest.

Differences in overall fatigue, peripheral fatigue, and central fatigue of hamstrings versus quadriceps between exercise modalities.

Determine the modalities of exercises which induce the highest level of fatigue and characterize the etiology of neuromuscular fatigue (i.e., peripheral or central) for typical drills performed daily by elite soccer players

Ratio (%) of initial to post-exercise values based on field indicators and neuromuscular fatigue.

Full Information

NCT ID

NCT04943510

First Posted

June 2, 2021

Last Updated

April 19, 2022

Sponsor

University Hospital, Strasbourg, France

1. Study Identification

Unique Protocol Identification Number

NCT04943510

Brief Title

Characterization of Hamstring and Quadriceps Neuromuscular Fatigue After Soccer Game

Acronym

QIF

Official Title

Characterization of Hamstring and Quadriceps Neuromuscular Fatigue After Different Modality of Training in Soccer Players

Study Type

Interventional

2. Study Status

Record Verification Date

April 2022

Overall Recruitment Status

Recruiting

Study Start Date

November 4, 2021 (Actual)

Primary Completion Date

July 2023 (Anticipated)

Study Completion Date

July 2023 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

University Hospital, Strasbourg, France

4. Oversight

Studies a U.S. FDA-regulated Drug Product

No

Studies a U.S. FDA-regulated Device Product

No

Data Monitoring Committee

No

5. Study Description

Brief Summary

This is a monocentric study comparing hamstring and quadriceps neuromuscular fatigue after simulated soccer game, anaerobic and aerobic training sessions. The purpose of this study was: To quantify the decrease of isometric force immediately after a simulate soccer game. To characterize peripheral and central fatigue between hamstring and quadriceps muscles and described the kinetics of recovery after specific tasks of soccer training. To compare the level neuromuscular fatigue induced by anaerobic and aerobic training. To highlight correlation between neuromuscular fatigue and performance markers.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Neuromuscular Fatigue, Exercise

Keywords

Hamstring, Neuromuscular fatigue, Soccer, Performance

7. Study Design

Primary Purpose

Basic Science

Study Phase

Phase 2

Interventional Study Model

Single Group Assignment

Model Description

three randomizations will be used to determine the order of the tests that will be proposed to the subjects: on the one hand for the exercise modalities (match, anaerobic, aerobic) and, on the other hand, for the exercise modalities included in the anaerobic and aerobic exercise families: Anaerobic agility / anaerobic - linear sprints Aerobic - shuttle / aerobic - linear

Masking

None (Open Label)

Allocation

N/A

Enrollment

15 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title

Physical exercices arm

Arm Type

Experimental

Arm Description

three randomizations will be used to determine the order of the tests that will be proposed to the subjects: on the one hand for the exercise modalities (match, anaerobic, aerobic) and, on the other hand, for the exercise modalities included in the anaerobic and aerobic exercise families: Anaerobic agility / anaerobic - linear sprints Aerobic - shuttle / aerobic - linear

Intervention Type

Other

Intervention Name(s)

Physical exercices

Other Intervention Name(s)

Non invasive muscular neurostimulations, Surface EMG

Intervention Description

surface EMG: surface electrodes will be positioned on the muscles to evaluate the level of muscle activation non invasive muscular neurostimulations : application of a percutaneous electrical stimulation of the motor nerve of the considered muscle and a direct electrical stimulation of the muscle

Primary Outcome Measure Information:

Title

Difference in maximal isometric hamstring strength before and immediately after exercise (i.e., pre vs. immediate post exercise) expressed as a percentage (%).

Time Frame

Before and immediately post exercise (i.e., during the first minute after cessation of exercise)

Secondary Outcome Measure Information:

Title

Relative difference (in %) in maximum isometric hamstring strength before and after exercise (i.e., pre- vs. post-exercise), relative to pre-exercise strength across different test types.

Time Frame