Use of Ulipristal Acetate in Induction of Second Trimester Missed Abortion
Induction of Second Trimester Abortion
About this trial
This is an interventional treatment trial for Induction of Second Trimester Abortion
Eligibility Criteria
Inclusion Criteria: • Women with 2nd trimester missed abortions
- Gestational age 13-26 weeks.
- Women with a previous caesarian section scar,(para 1cs till para 4 cs).
- Women counseled and chose medication abortion rather than surgical evacuation
Exclusion Criteria:
- Women with an accompanying medical disorder such as: Preeclampsia, Diabetes Mellitus or Heart disease.
- Primigravida women or non scarred uterus.
- Women with previous myomectomy or hysterotomy scar or upper segment caesarean section scar.
- Induction of abortion in women with congenital fetal malformations or positive fetal pulsations due to medical disorder.
- Women with placenta previa .
- Allergy or contraindications to either Ulipristal acetate or Misoprostol.
- Women with inevitable abortion in the form of vaginal bleeding or uterine contractions
Sites / Locations
- Ain SHams Maternity Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
ulipristal group
placebo
received Ulipristal acetate 30mg, starting misoprostol 12 hours later 100µg every 6 hours buccal according to FIGO guidelines 2017,Then women had rest for 24 hours after 5 doses of misoprostol and restarted misoprostol-only in both groups with the same above regimens, repeating the same sequence for two weeks unless there was excessive bleeding or infection or uterine contractions or cervical changes. If failed, patient proceeded to hysterotomy
received placebo tablet of same shape , texture of that of ulipristal then 12 hours later start misoprostol 100µg every 6 hours buccal according to FIGO guidelines 2017. Then women in had rest for 24 hours after 5 doses of misoprostol and restarted misoprostol-only in both groups with the same above regimens, repeating the same sequence for two weeks unless there was excessive bleeding or infection or uterine contractions or cervical changes. If failed, patient proceeded to hysterotomy