Neurophysiological Assessment in Patients With Multiple Sclerosis
Multiple Sclerosis, Demyelinating Disease, Inflammatory Disease
About this trial
This is an interventional basic science trial for Multiple Sclerosis focused on measuring neurophysiology, TMS-EEG, multiple sclerosis
Eligibility Criteria
Inclusion Criteria:
- MS diagnosis according to the latest McDonald criteria
Exclusion Criteria:
- other neurological or immunological diseases
- clinical relapses in the 30 days prior to the clinical and neurophysiological evaluation;
- presence of conditions that contraindicate the execution of Transcranial Magnetic Stimulation (TMS) methods (history of epilepsy, pacemaker, recent head injury).
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Other
MS patients
Healthy controls
All MS patients will undergo clinical and neurophysiological evaluation at baseline (T0). The baseline will consider the radiological data of disease activity obtained from the most recently performed MRI according to clinical practice. These evaluations will be repeated according to clinical practice in patients taking DMT or every 6 months, in a stable condition or according to the indication of the treating neurologist in case of disease reactivation. A one-year neurophysiological, clinical and radiological observation is foreseen. Healthy subjects will undergo only the neurophysiological evaluation at baseline.
Healthy subjects will undergo only the neurophysiological evaluation at baseline.