TBS,TMS, Suicidal Ideation, Magnetic Resonance Imaging, Dorsolateral Prefrontal Cortex, Ventrolateral Prefrontal Cortex
Late Life Depression
About this trial
This is an interventional treatment trial for Late Life Depression focused on measuring TMS, TBS
Eligibility Criteria
Inclusion Criteria:
- Age > 50 years.
- Major depressive disorder (MDD).
- Right handiness
- with a score ≥ 12 on the Beck Scale of Suicidal Ideation (BSSI) and a score of at least 3 on Question #3 (Suicide: 3 ideas and gestures of suicide) of the HAMD
Exclusion Criteria:
- Inability to provide informed consent.
- Dementia, as defined by MoCA 23/24. Other major mental or current psychotic symptoms
- Active current suicidal intent as evidenced or the endorsement of an actual attempt, interrupted attempt,
- Have known preexisting noise-induced hearing loss, concurrent treatment with ototoxic medications, or with cochlear implants are on medications known to lower seizure threshold.
- Alcohol or other substances abuse of or dependence on within the past 3 months Organic brain, head trauma,
- Elevated risk of seizure due to TBI
- Participation in concurrent clinical trial
- Non-correctable clinically significant sensory impairment (i.e., cannot hear well enough to cooperate with interview).
- Unstable medical illness, including delirium, malignancy, uncontrolled diabetes mellitus, hypertension, hyperlipidemia, or cerebrovascular or cardiovascular risk factors that are not under medical management. Unstable cardiac disease or recent (<3m) myocardial infarction
- Mental implement in the brain, claustrophobia
- Ever received ECT, TMS Consent procedures.
Sites / Locations
- "MAGSTIM" Repetitive transcranial magnetic stimulator(rTMS) SystemRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Placebo Comparator
dorsolateral prefrontal cortex
ventrolateral prefrontal cortex
sham comparator
Age > 50 years. Major depressive disorder (MDD). Right handiness with a score ≥ 12 on the Beck Scale of Suicidal Ideation (BSSI) and a score of at least 3 on Question #3 (Suicide: 3 ideas and gestures of suicide) of the HAMD
Age > 50 years. Major depressive disorder (MDD). Right handiness with a score ≥ 12 on the Beck Scale of Suicidal Ideation (BSSI) and a score of at least 3 on Question #3 (Suicide: 3 ideas and gestures of suicide) of the HAMD
Age > 50 years. Major depressive disorder (MDD). Right handiness with a score ≥ 12 on the Beck Scale of Suicidal Ideation (BSSI) and a score of at least 3 on Question #3 (Suicide: 3 ideas and gestures of suicide) of the HAMD