Enhancing Skeletal Adaptations to PTH and Exercise (ESkAPE)
Exercise, Bone Resorption, Bone Formation
About this trial
This is an interventional basic science trial for Exercise focused on measuring Acute exercise, Exercise training, Bone resorption, Bone formation, Parathyroid hormone, Calcium homeostasis
Eligibility Criteria
Inclusion Criteria:
Female and male Veterans aged 25 to 45 y and 55 to 75 y will be enrolled. Eligible volunteers will be normally active (e.g., recreational cycling or walking) but will not participate in regular moderate-to-vigorous exercise. Women will be premenopausal with regular menstrual cycles or postmenopausal, defined as absence of menses for at least 12 mo or, in those who underwent a hysterectomy, a serum follicle stimulating hormone (FSH) >30 mIU/mL.
Exclusion Criteria:
Initiation or change in dose in the past 6 months of medications that affect bone metabolism
- e.g., osteoporosis medications, thiazide/loop diuretics, systemic glucocorticoids
- BMD T-score <-2.5 at the total hip, femoral neck, or lumbar spine
- Impaired renal function, defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m2
- Abnormal alkaline phosphatase
- Untreated thyroid dysfunction, defined as an ultrasensitive thyroid stimulating hormone (TSH) <0.5 or >5.0 mU/L
- Serum Ca <8.5 or >10.3 mg/dL
- Serum 25(OH)D <20 ng/mL
- Uncontrolled hypertension (resting systolic blood pressure (BP) >150 mmHg or diastolic BP >90 mmHg)
- Type 1 diabetes
- Type 2 diabetes if on insulin or sulfonylurea therapy
- hemoglobin A1c >7%
Cardiovascular disease; defined as subjective or objective indicators of ischemic heart disease (e.g., angina, ST segment depression) or serious arrhythmias at rest or during the graded exercise test (GXT)
- volunteers who have a positive GXT can be re-considered after follow-up evaluation by a cardiologist
- Anemia (hemoglobin <12.1 g/dL for women, <14.3 g/dL for men)
- Fracture in the past 6 months
Body mass index >39 kg/m2
- In the event of abnormal eGFR, alkaline phosphatase, TSH, BP, 25(OH)D, or hemoglobin values, volunteers can be reassessed, including after appropriate follow-up evaluation and treatment by their health care provider
Sites / Locations
- Rocky Mountain Regional VA Medical Center, Aurora, CORecruiting
Arms of the Study
Arm 1
Other
Exercise
All participants engage in exercise training