Effectiveness Of High Dose Melatonin As Adjunctive Therapy For Dengue Fever With Warning Signs
Dengue Fever With Warning Signs
About this trial
This is an interventional treatment trial for Dengue Fever With Warning Signs
Eligibility Criteria
Inclusion Criteria:
1. Patient aged 5 to 18 years old with febrile episodes (Temperature >/= 37.8 degrees Celsius) with positive Dengue NS1.
2. Patients with Dengue Fever on the Department of Health 2012 definition of Dengue fever with Warning Signs with any one of the following:
- Abdominal tenderness
- Persistent vomiting
- Minimal mucosal bleed
Platelet count less than or equal to 100,000
Exclusion Criteria:
1. Patients with signs and symptoms related to dengue fever but with negative Dengue Ns1 result.
2. Patients diagnosed as Severe Dengue or Dengue Shock. 3. Patients unable to tolerate tablet formulation. 4. Patients placed on nothing per Orem. 5. Patients previously treated in a referring facility.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Treatment Group
Control Group
Other than the guided management of Dengue Fever with warning signs, the treatment group will receive a standard dose of 20mg/day of melatonin20-21 for 5 days. The dosing was based on the study by Leiberman et al and Malhotra et al. If a patient is unable to tolerate the whole or punctured tablet, it will be given with milk or water. There is no known interaction between melatonin and milk known to date. Daily complete blood count will be done and be recording in an electronic record using Microsoft Excel.
Other than the guided management of Dengue Fever with warning signs, the control group will be manage according the Department of Health Dengue Management Guideline. No placebo will be given.