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The Effect of Resistance Exercise on Inflammation in Young and Older Adults

Primary Purpose

Aging, Inflammatory Response

Status
Completed
Phase
Not Applicable
Locations
Taiwan
Study Type
Interventional
Intervention
Resistance exercise
Sponsored by
National Taiwan Normal University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Aging

Eligibility Criteria

20 Years - 80 Years (Adult, Older Adult)MaleAccepts Healthy Volunteers

Inclusion Criteria:

  • Age: 20-80
  • Healthy male
  • Without experience of resistance training

Exclusion Criteria:

  • No acute or chronic musculoskeletal symptoms
  • Smoking
  • Alcohol or drug abuse
  • Fail to conduct resistance exercise

Sites / Locations

  • National Taiwan Normal University

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

No Intervention

Arm Label

High-load resistance exercise

Sedentary control

Arm Description

Subjects in high-load trial performed 3 sets per exercise, 8 repetitions with load of 70%-1RM with 90 sec of rest between sets, followed by a fourth set to voluntary failure.

Subjects in control trial stayed sedentary during the period.

Outcomes

Primary Outcome Measures

Changes in biomarkers of inflammation
Biomarkers of inflammation will be measured such as IL-10 in pg/mL, IL-6 in pg/mL, TNF-α in pg/mL.

Secondary Outcome Measures

Changes in glucose
glucose in mg/dL
Changes in metabolic parameters
Metabolic parameters will be measured such as TC in mg/dL, TG in mg/dL, and HDL in mg/dL.
Changes in biomarkers of muscle damage
Biomarkers of muscle damage will be measured such as CK in U/L and LDH in U/L.
Changes in molecular markers in peripheral blood mononuclear cells (PBMC)
Molecular markers in PBMC will be measured such as STAT3 in arbitrary units, IKK in arbitrary units, IkB in arbitrary units, p65 in arbitrary units, SOCS3 in arbitrary units, AMPK in arbitrary units, and SIRT1 in arbitrary units.
Changes in complete blood count (CBC)
The white blood cell count and the count of each white blood cell type will be measured.
Borgs Ratings of Perceived Exertion (RPE)
Borgs RPE is a method of estimating exertion rating, based on a 6 to 20 rating scale (6 being the no exertion at all, 20 being maximal exertion).

Full Information

First Posted
September 2, 2021
Last Updated
January 12, 2023
Sponsor
National Taiwan Normal University
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1. Study Identification

Unique Protocol Identification Number
NCT05042167
Brief Title
The Effect of Resistance Exercise on Inflammation in Young and Older Adults
Official Title
The Acute Effect of High-load Resistance Exercise on Inflammation in Young and Older Adults
Study Type
Interventional

2. Study Status

Record Verification Date
January 2023
Overall Recruitment Status
Completed
Study Start Date
October 1, 2021 (Actual)
Primary Completion Date
December 31, 2022 (Actual)
Study Completion Date
December 31, 2022 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
National Taiwan Normal University

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No

5. Study Description

Brief Summary
Healthy young and older adults will complete two trials in a randomized crossover counter-balanced order, including resistance exercise and sedentary control. During each trial, blood samples will be collected. The investigators hypothesized that an acute bout of resistance exercise exert different inflammation responses in young and older adults.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Aging, Inflammatory Response

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Crossover Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
16 (Actual)

8. Arms, Groups, and Interventions

Arm Title
High-load resistance exercise
Arm Type
Experimental
Arm Description
Subjects in high-load trial performed 3 sets per exercise, 8 repetitions with load of 70%-1RM with 90 sec of rest between sets, followed by a fourth set to voluntary failure.
Arm Title
Sedentary control
Arm Type
No Intervention
Arm Description
Subjects in control trial stayed sedentary during the period.
Intervention Type
Other
Intervention Name(s)
Resistance exercise
Intervention Description
4 total resistance exercises that target all major muscle groups.
Primary Outcome Measure Information:
Title
Changes in biomarkers of inflammation
Description
Biomarkers of inflammation will be measured such as IL-10 in pg/mL, IL-6 in pg/mL, TNF-α in pg/mL.
Time Frame
24-hour during each study intervention
Secondary Outcome Measure Information:
Title
Changes in glucose
Description
glucose in mg/dL
Time Frame
24-hour during each study intervention
Title
Changes in metabolic parameters
Description
Metabolic parameters will be measured such as TC in mg/dL, TG in mg/dL, and HDL in mg/dL.
Time Frame
24-hour during each study intervention
Title
Changes in biomarkers of muscle damage
Description
Biomarkers of muscle damage will be measured such as CK in U/L and LDH in U/L.
Time Frame
24-hour during each study intervention
Title
Changes in molecular markers in peripheral blood mononuclear cells (PBMC)
Description
Molecular markers in PBMC will be measured such as STAT3 in arbitrary units, IKK in arbitrary units, IkB in arbitrary units, p65 in arbitrary units, SOCS3 in arbitrary units, AMPK in arbitrary units, and SIRT1 in arbitrary units.
Time Frame
24-hour during each study intervention
Title
Changes in complete blood count (CBC)
Description
The white blood cell count and the count of each white blood cell type will be measured.
Time Frame
24-hour during each study intervention
Title
Borgs Ratings of Perceived Exertion (RPE)
Description
Borgs RPE is a method of estimating exertion rating, based on a 6 to 20 rating scale (6 being the no exertion at all, 20 being maximal exertion).
Time Frame
1-hour during each exercise intervention

10. Eligibility

Sex
Male
Gender Based
Yes
Minimum Age & Unit of Time
20 Years
Maximum Age & Unit of Time
80 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: Age: 20-80 Healthy male Without experience of resistance training Exclusion Criteria: No acute or chronic musculoskeletal symptoms Smoking Alcohol or drug abuse Fail to conduct resistance exercise
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Hung-Wen Liu, Ph.D.
Organizational Affiliation
National Taiwan Normal University
Official's Role
Principal Investigator
Facility Information:
Facility Name
National Taiwan Normal University
City
Taipei
ZIP/Postal Code
162
Country
Taiwan

12. IPD Sharing Statement

Plan to Share IPD
No

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The Effect of Resistance Exercise on Inflammation in Young and Older Adults

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