Effect of Perioperative Ultrasound-guided Remote Ischemic Conditioning on Acute Myocardial Infarction
Acute Myocardial Infarction
About this trial
This is an interventional treatment trial for Acute Myocardial Infarction focused on measuring Remote ischemic conditioning, Percutaneous coronary intervention, Infarction, Myocardial injury, Acute myocardial infarction
Eligibility Criteria
Inclusion Criteria:
- Newly developed ST segment elevation myocardial infarction (STEMI) and non-ST segment elevation myocardial infarction (non-STEMI) according to clinical symptoms, ECG and laboratory confirmation;
- Patients aged 18-80 yr;
- Scheduled for PCI;
- With normal cognitive function indicated by MMSE score >16 and able to cooperate with intervention;
- Agreed to participate and signed the consent form.
Exclusion Criteria:
- Previous STEMI or non-STEMI;
- Previous coronary artery bypass grafting (CABG) ;
- Developed thrombolysis within the last 30 days;
- Cardiogenic shock history;
- Persistent atrial fibrillation history;
- Severe complications (e.g. ventricular septal rupture, free wall rupture or acute severe mitral regurgitation) warrant surgical interventions;
- Uncontrolled hypertension (systolic blood pressure >160mmHg or diastolic blood pressure >100mmHg);
- With peripheral neuropathy, peripheral artery disease, superficial thrombophlebitis or deep vein thrombosis;
- Other severe systemic diseases;
- Participated in other trials previously.
Sites / Locations
- The First Affiliated Hospital of Nanjing Medical UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Other
Ultrasound-guided-RIC group
Traditional RIC group
Control group
Patients in the ultrasound-guided-RIC group will receive percutaneous coronary intervention (PCI), usual pharmacotherapy and pre-, per-, and post-operative ultrasound-guided remote ischemic conditioning (RIC). The pressure applied during cuff inflation is total occlusion pressure (TOP) determined with ultrasound measurement.
Patients in the traditional RIC group will receive PCI, usual pharmacotherapy and pre-, per-, and post-operative traditional RIC. The pressure applied during cuff inflation is 20 mmHg above systolic blood pressure.
Patients in the control group will receive PCI and usual pharmacotherapy.