18F-MFBG PET/CT in the Evaluation of Neural Crest Tumor
Neuroendocrine Tumor, Neuroblastoma, Pheochromocytoma
About this trial
This is an interventional diagnostic trial for Neuroendocrine Tumor
Eligibility Criteria
Inclusion Criteria:
- The subject has read, signed, and dated an informed consent form (ICF) prior to any study procedures being performed. Patients with histologically confirmed multifocal and/or metastatic neural crest tumor.
Subject should have a routine clinical 131I-MIBG scintigraphy (planar + SPECT/CT) performed within 6 months prior to the inclusion visit or scheduled within 3 months after the inclusion visit.
The subject is male or is a nonpregnant, nonlactating female who is either surgically sterile or is post-menopausal. The subject is able and willing to comply with all study procedures as described in the protocol.
Exclusion Criteria:
- Patients are potentially pregnant (serum and urinary hCG test will be performed in women where pregnancy is not excluded) or is breast-feeding.
Patients undergo surgery between the selection and inclusion visit. Patients who are pregnant, may possibly be pregnant, or wish (including their partners) to become pregnant during the study period, or are lactating. Patients who are not suitable to participate in the trial according to researchers.
Sites / Locations
- Peking union medical college hospitalRecruiting
Arms of the Study
Arm 1
Experimental
18F-MFBG PET/CT in neuroendocrine malignancies
Each patient receive a single intravenous injection of 18F-MFBG 2-4 MBq/kg and undergo PET/CT scan after 60 min post-injection. Patients with neuroblastoma should have a routine clinical 123I-MIBG scintigraphy (planar and/or SPECT/CT) performed within 6 months prior to the inclusion visit or scheduled within 3 months after the inclusion visit.