A Clinical Trial Investigating the Effect of Salmon Bone Meal on Osteoarthritis Among Men and Women
Osteoarthritis, Osteoarthritis, Knee, Osteoarthritis, Hip
About this trial
This is an interventional prevention trial for Osteoarthritis focused on measuring stiffness, pain, knee pain, hip pain, osteoarthritis
Eligibility Criteria
Inclusion Criteria:
- Characteristic joint pain indicating osteoarthritis (OA) in the hip(s) or knee(s).
- A radiologically and clinically verified diagnosis of mild to moderate OA graded 1-3 on a Kellgren-Lawrence (KL) grading scale in affected hips or knees.
- Age 18-70 years.
- Familiar with the Norwegian language, both in writing and orally.
- Willingness to participate in the study.
Exclusion Criteria:
- A radiologically and clinically verified diagnosis of severe OA graded 4 on a KL grading scale in affected hips or knees.
- Use of drugs (and supplements) known to influence bone and joint metabolism.
- Pregnancy or breastfeeding
- Known fish allergy and history of hypersensitivity to any of the components in the interventional product.
- Other reasons in which the principal investigator deems it necessary to exclude a potential participant.
Sites / Locations
- Kristiansund Hospital
- Hofseth Biocare ASA
- Lovisenberg Diakonale Sykehus
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Placebo Comparator
Experimental
Hydrolyzed Collagen type II
Maltodextrin
Unhydrolyzed Collagen type II (Salmon bone meal)
10 capsules daily of hydrolyzed collagen (CH) type II is taken per orally. Each capsule contains ~500 mg of CH. Once or twice daily dosing. Duration: 6 months.
10 capsules daily of maltodextrin is taken per orally. Each capsule contains 500 mg of maltodextrin. Once or twice daily dosing. Duration: 6 months.
10 capsules daily of salmon bone meal enriched with vitamin D3 is taken per orally. Each capsule contains 300 mg of maltodextrin, 200 mg of salmon bone meal (10 capsules = 2000 mg salmon bone meal = 340 mg elemental calcium in the form of microcrystalline hydroxyapatite), and 4 micrograms of vitamin D3 (10 capsules = 40 micrograms of vitamin D3 = 1600 IU).