Cold, Appetite and Weight Loss in Individuals With Obesity
Weight Loss, Cold Exposure, Appetitive Behavior
About this trial
This is an interventional treatment trial for Weight Loss focused on measuring weight loss, appetite, cold exposure, obesity, nutritional intervention
Eligibility Criteria
Inclusion Criteria:
- Present a 27≥BMI,
- Present a waist circumference >88 cm
- Must be weight-stable (±2 kg last 6 months)
- Must be sedentary (<2 times/week of 30 min of continuous exercise)
- Must be able to read in English
- Must to present no history of alcohol or drugs abuse
In addition, Women will be included if:
• Must be pre-menopausal with a regular menstrual cycle
Exclusion Criteria:
- present any history or evidence of cardiovascular disease
- present any history or evidence of peripheral vascular disease
- present any history or evidence of stroke
- present a current diagnosis of an axis 1 psychiatric disorder (i.e. mood, anxiety and eating disorders);
- be insulin dependent (75g oral glucose tolerance test)
- present a known renal and/or liver disease
- asthma requiring therapy
- plasma cholesterol > 8 mmol/L
- systolic blood pressure > 140 mmHg or diastolic blood pressure > 90 mmHg
- present previous history of inflammation disease
- present previous history of cancer
- present untreated thyroid or pituitary disease
- present a regular consumption of medications that could affect cardiovascular function and/or metabolism (i.e. MAO inhibitors, pressor agents, warfarin, anticonvulsants, phenylbutazone, or tricyclic antidepressants)
- present food allergies
- be smoker
- present alcohol intake that exceeds recommendations or alcoholism
- present current addictions to opiates, cocaine or stimulants
- be pregnant or planning to become pregnant over the course of the study
- be peri- or post-menopausal
- have had surgically induced menopause
Sites / Locations
- University of OttawaRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
Only diet group
Only cold exposure group
Combined diet + cold exposure group
Dietary energy prescription at -30% of Energy requirements (50% carbohydrate; 30% fat; 20% protein) during 8 weeks. Follow up with a registered dietitian.
No dietary intervention. Visit at laboratory every 2nd day during the 8-week intervention to undergo the cold exposure as follows: 2 weeks of exposure at 18 degrees, 2 weeks of exposure at 14 degrees and 4 weeks of 10 degrees of exposure during 90 min.
Dietary energy prescription at -30% of Energy requirements (50% carbohydrate; 30% fat; 20% protein). Follow up with a registered dietitian. Visit at laboratory every 2nd day during the 8-week intervention to undergo the cold exposure as follows: 2 weeks of exposure at 18 degrees, 2 weeks of exposure at 14 degrees and 4 weeks of 10 degrees of exposure during during 90 min.