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Mirror Illusion Training and Cross-education

Primary Purpose

Exercise Therapy, Weight Lifting

Status
Unknown status
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Unilateral resistance training
Illusionary mirror visual feedback
Sponsored by
Texas Christian University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional basic science trial for Exercise Therapy focused on measuring Strength training, Mirror visual feedback

Eligibility Criteria

18 Years - 35 Years (Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

  • right-hand dominance
  • no previous strength training of upper body last 3 months
  • no injuries or recent surgeries of the upper limbs
  • willingness to adhere to the strength training requirements of the study

Exclusion Criteria:

  • current use of hormone replacement therapy
  • pregnancy/breastfeeding

Sites / Locations

  • TCU Neuromuscular Physiology Laboratory
  • TCU RIC

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

Experimental

Arm Label

Resistance training control group

Resistance training with mirror illusion group

Arm Description

The resistance training control group will perform unilateral resistance training on their dominant arm. The training will be performed twice per week for four weeks totaling eight training sessions.

The resistance training with mirror illusion group will perform unilateral resistance training on their dominant arm. During training, they will view a mirror illusion of their exercising arm over their opposite, non-exercising arm. The training will be performed twice per week for four weeks totaling eight training sessions.

Outcomes

Primary Outcome Measures

Change in dynamic muscle strength for the trained and untrained arm
Dynamic 1-repetition maximum (lbs)
Change in isometric muscle strength for the trained and untrained arm
Isometric maximal voluntary contraction
Change in lean mass for the trained and untrained arm
DEXA (g)
Change in muscle thickness for the trained and untrained arm
Ultrasound muscle thickness (cm)
Change in muscle activation for the trained and untrained arm
Electromyographic amplitude (volts)

Secondary Outcome Measures

Full Information

First Posted
October 7, 2021
Last Updated
October 7, 2021
Sponsor
Texas Christian University
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1. Study Identification

Unique Protocol Identification Number
NCT05084690
Brief Title
Mirror Illusion Training and Cross-education
Official Title
Mirror Illusion Training to Improve Contralateral Arm Strength
Study Type
Interventional

2. Study Status

Record Verification Date
October 2021
Overall Recruitment Status
Unknown status
Study Start Date
July 19, 2021 (Actual)
Primary Completion Date
August 19, 2023 (Anticipated)
Study Completion Date
August 19, 2023 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Texas Christian University

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
Cross-education describes the transfer of motor performance to the opposite limb following unilateral training and is primarily explained by adaptations within the brain. The mirror training hypothesis suggests that illusionary mirror visual feedback may augment the cross-education of strength to the untrained, contralateral limb. The purpose of this project is to examine how the use of illusionary mirror visual feedback shapes the neuromuscular adaptations that occur for both limbs during unilateral (single-limb) strength training. Our hypothesis is that mirror training will augment the level of cross-education for the untrained arm.
Detailed Description
Recent empirical evidence shows a heightened level of strength transfer with the use of illusionary mirror visual feedback, but this was shown for the small muscles of the wrist during isokinetic training. It is unknown if larger, multi-joint muscles respond favorably to mirror training in practical settings. A randomized controlled study design will allocate approximately 20 participants into two groups. One group will perform unilateral strength training with illusionary mirror visual feedback (Mirror) and the other will perform the same unilateral strength training but without a mirror (No-Mirror). The intervention will involve four weeks of unilateral strength training performed twice weekly at high intensities (>80%1RM).

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Exercise Therapy, Weight Lifting
Keywords
Strength training, Mirror visual feedback

7. Study Design

Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Model Description
Randomized, two arm parallel experimental and control groups
Masking
Outcomes Assessor
Allocation
Randomized
Enrollment
20 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Resistance training control group
Arm Type
Active Comparator
Arm Description
The resistance training control group will perform unilateral resistance training on their dominant arm. The training will be performed twice per week for four weeks totaling eight training sessions.
Arm Title
Resistance training with mirror illusion group
Arm Type
Experimental
Arm Description
The resistance training with mirror illusion group will perform unilateral resistance training on their dominant arm. During training, they will view a mirror illusion of their exercising arm over their opposite, non-exercising arm. The training will be performed twice per week for four weeks totaling eight training sessions.
Intervention Type
Other
Intervention Name(s)
Unilateral resistance training
Intervention Description
Unilateral resistance training of the elbow flexors
Intervention Type
Other
Intervention Name(s)
Illusionary mirror visual feedback
Intervention Description
Modified Ramachandran's mirror box
Primary Outcome Measure Information:
Title
Change in dynamic muscle strength for the trained and untrained arm
Description
Dynamic 1-repetition maximum (lbs)
Time Frame
Baseline (week 0) post-training (week 5)
Title
Change in isometric muscle strength for the trained and untrained arm
Description
Isometric maximal voluntary contraction
Time Frame
Baseline (week 0) post-training (week 5)
Title
Change in lean mass for the trained and untrained arm
Description
DEXA (g)
Time Frame
Baseline (week 0), mid-training (week 2), post-training (week 5)
Title
Change in muscle thickness for the trained and untrained arm
Description
Ultrasound muscle thickness (cm)
Time Frame
Baseline (week 0), mid-training (week 2), post-training (week 5)
Title
Change in muscle activation for the trained and untrained arm
Description
Electromyographic amplitude (volts)
Time Frame
Baseline (week 0) post-training (week 5)

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
35 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: right-hand dominance no previous strength training of upper body last 3 months no injuries or recent surgeries of the upper limbs willingness to adhere to the strength training requirements of the study Exclusion Criteria: current use of hormone replacement therapy pregnancy/breastfeeding
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Joshua C Carr
Organizational Affiliation
Texas Christian University
Official's Role
Principal Investigator
Facility Information:
Facility Name
TCU Neuromuscular Physiology Laboratory
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76126
Country
United States
Facility Name
TCU RIC
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76126
Country
United States

12. IPD Sharing Statement

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Mirror Illusion Training and Cross-education

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