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Resistance Training in Adults With Obesity

Primary Purpose

Overweight and Obesity

Status
Completed
Phase
Not Applicable
Locations
Norway
Study Type
Interventional
Intervention
Moderate-repetition resistance training
High-repetition resistance training
Sponsored by
Norwegian University of Science and Technology
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Overweight and Obesity focused on measuring Exercise therapy, Muscular strength, Resistance training, Fitness testing, Healthy lifestyle

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

  • Obesity (BMI ≥ 30) or
  • Central obesity (defined according to the International Diabetes Federation).

Exclusion Criteria:

  • Unstable angina
  • recent cardiac infarction (last 4 weeks)
  • uncompensated heart failure
  • severe valvular illness
  • pulmonary disease
  • uncontrolled hypertension
  • kidney failure
  • orthopaedic/neurological limitations
  • cardiomyopathy
  • planned operations during the research period
  • participation in a parallel study

Sites / Locations

  • Department of Circulation and Medical Imaging

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Experimental

Arm Label

Moderate-repetition resistance training

High-repetition resistance training

Arm Description

The participants will undergo a full-body resistance training protocol with moderate repetitions (6-12), moderate load (70-85% of 1RM), and moderate rest between sets (60-90s). Training will be undertaken three times per week.

The participants will undergo a full-body resistance training protocol with high repetitions (15+), low load (<60% of 1RM), and short rest between sets (30s). Training will be undertaken three times per week.

Outcomes

Primary Outcome Measures

Glycated haemoglobin (HbA1c)

Secondary Outcome Measures

Fasting glucose
Blood lipid concentration
C-reactive protein
Systolic blood pressure
Diastolic blood pressure
Body fat
Measured by bioelectrical impedance (InBody 770)
Fat-free mass
Measured by bioelectrical impedance (InBody 770)
Body mass
Measured by bioelectrical impedance (InBody 770)
Visceral fat area
Measured by bioelectrical impedance (InBody 770)
Waist circumference
VO2max (maximal aerobic capacity)
Rate of force development
Measured by Kistler force plate
Muscular strength (1RM)
Leg press and bench press
Muscular endurance
Maximum number of repetitions using 50% of 1-RM
Physical activity
Assessed at three timepoints throughout the intervention using SenseWear armband activity monitors and/or Personal Activity IntelligenceTM (using heart rate monitors and smart phone application).
Health-Related Quality of Life
Using the Short-Form 36 survey and Satisfaction with Physical Function and Appearance Survey

Full Information

First Posted
September 20, 2021
Last Updated
May 25, 2022
Sponsor
Norwegian University of Science and Technology
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1. Study Identification

Unique Protocol Identification Number
NCT05092061
Brief Title
Resistance Training in Adults With Obesity
Official Title
Acute and Chronic Effects of Two Different Types of Resistance Training on Cardiometabolic Health in Adults With Obesity
Study Type
Interventional

2. Study Status

Record Verification Date
May 2022
Overall Recruitment Status
Completed
Study Start Date
October 14, 2021 (Actual)
Primary Completion Date
February 28, 2022 (Actual)
Study Completion Date
February 28, 2022 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Norwegian University of Science and Technology

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
The purpose of this project is two-fold: (1) to assess if two different resistance training protocols elicit different responses in the acute phase and (2) to assess if the same two different protocols will elicit different long-term responses on muscular strength, body composition and cardiometabolic health. The project will include 30 adults with obesity (defined as BMI ≥ 30 or abdominal obesity according to the International Diabetes Federation). In the acute phase blood lactate, heart rate, enjoyment and perceived exertion will be assessed after the two resistance training protocols. In addition, the mean 24-h blood glucose concentration after exercise will be compared between the two protocols. For the long-term effects blood markers of cardiometabolic health, blood pressure, body composition, objectively measured physical activity and physical fitness will be assessed before and after the intervention. Also, perceived health-related quality of life will be assessed before and after the intervention.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Overweight and Obesity
Keywords
Exercise therapy, Muscular strength, Resistance training, Fitness testing, Healthy lifestyle

7. Study Design

Primary Purpose
Prevention
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Model Description
The study will consist of both a crossover study model (acute phase) and parallel model (chronic phase).
Masking
None (Open Label)
Allocation
Randomized
Enrollment
31 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Moderate-repetition resistance training
Arm Type
Experimental
Arm Description
The participants will undergo a full-body resistance training protocol with moderate repetitions (6-12), moderate load (70-85% of 1RM), and moderate rest between sets (60-90s). Training will be undertaken three times per week.
Arm Title
High-repetition resistance training
Arm Type
Experimental
Arm Description
The participants will undergo a full-body resistance training protocol with high repetitions (15+), low load (<60% of 1RM), and short rest between sets (30s). Training will be undertaken three times per week.
Intervention Type
Other
Intervention Name(s)
Moderate-repetition resistance training
Intervention Description
Will undertake resistance training with moderate loads, and moderate repetitions 3 times per week for 7 weeks.
Intervention Type
Other
Intervention Name(s)
High-repetition resistance training
Intervention Description
Will undertake resistance training with low loads, and high repetitions 3 times per week for 7 weeks.
Primary Outcome Measure Information:
Title
Glycated haemoglobin (HbA1c)
Time Frame
7 weeks
Secondary Outcome Measure Information:
Title
Fasting glucose
Time Frame
7 weeks
Title
Blood lipid concentration
Time Frame
7 weeks
Title
C-reactive protein
Time Frame
7 weeks
Title
Systolic blood pressure
Time Frame
7 weeks
Title
Diastolic blood pressure
Time Frame
7 weeks
Title
Body fat
Description
Measured by bioelectrical impedance (InBody 770)
Time Frame
7 weeks
Title
Fat-free mass
Description
Measured by bioelectrical impedance (InBody 770)
Time Frame
7 weeks
Title
Body mass
Description
Measured by bioelectrical impedance (InBody 770)
Time Frame
7 weeks
Title
Visceral fat area
Description
Measured by bioelectrical impedance (InBody 770)
Time Frame
7 weeks
Title
Waist circumference
Time Frame
7 weeks
Title
VO2max (maximal aerobic capacity)
Time Frame
7 weeks
Title
Rate of force development
Description
Measured by Kistler force plate
Time Frame
7 weeks
Title
Muscular strength (1RM)
Description
Leg press and bench press
Time Frame
7 weeks
Title
Muscular endurance
Description
Maximum number of repetitions using 50% of 1-RM
Time Frame
7 weeks
Title
Physical activity
Description
Assessed at three timepoints throughout the intervention using SenseWear armband activity monitors and/or Personal Activity IntelligenceTM (using heart rate monitors and smart phone application).
Time Frame
Baseline (before intervention), 4 and 7 weeks.
Title
Health-Related Quality of Life
Description
Using the Short-Form 36 survey and Satisfaction with Physical Function and Appearance Survey
Time Frame
7 weeks

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: Obesity (BMI ≥ 30) or Central obesity (defined according to the International Diabetes Federation). Exclusion Criteria: Unstable angina recent cardiac infarction (last 4 weeks) uncompensated heart failure severe valvular illness pulmonary disease uncontrolled hypertension kidney failure orthopaedic/neurological limitations cardiomyopathy planned operations during the research period participation in a parallel study
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Øystein Risa
Organizational Affiliation
Norwegian University of Science and Technology
Official's Role
Study Director
Facility Information:
Facility Name
Department of Circulation and Medical Imaging
City
Trondheim
ZIP/Postal Code
7491
Country
Norway

12. IPD Sharing Statement

Plan to Share IPD
No

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Resistance Training in Adults With Obesity

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