The Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Alzheimer's Disease
Alzheimer Disease
About this trial
This is an interventional treatment trial for Alzheimer Disease focused on measuring Alzheimer's Disease, Repetitive Transcranial Magnetic Stimulation, Cognitive Function, Aerobic Exercise, Functional MRI, Resting State Networks
Eligibility Criteria
Inclusion Criteria:
- having clinical AD diagnosis according to the NINCDS-ADRDA (National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association) criteria
- being 60 years and older
- having Clinical Dementia Rating Scale (CDR) scores 1 or 2
- living independently
Exclusion Criteria:
- not being able to walk independently,
- having physical disabilities,
- having a history of alcohol / substance abuse,
- having head trauma
- having epileptic seizures
Sites / Locations
- Istanbul Medipol University
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Active Comparator
TMS group
AE group
Control group
In the TMS group (n=10) rTMS was applied to the bilateral dorsolateral prefrontal cortex (DLPFC) at 20 Hz, for 5 consecutive days per week for over 2 weeks (totally 10 sessions) in addition to the pharmacological treatment.
AE group (n=9) received a moderate- intensity aerobic exercise program lasting 50 minutes per session, 5 consecutive days per week for over 2 weeks (totally 10 sessions) in addition to the pharmacological treatment.
No additional intervention was given to the patients in the control group (n=8) and participants were only treated pharmacologically.