Adaptation to Ozone in Individuals With Asthma/Exercise-induced Bronchoconstriction
Asthma, Asthma, Exercise-Induced, Exercise Induced Asthma
About this trial
This is an interventional basic science trial for Asthma focused on measuring Ozone, Air pollution, Asthma, Exercise-induced bronchoconstriction
Eligibility Criteria
Inclusion Criteria:
- Recreationally active individuals
- Diagnosed asthma and/or mild exercise-induced bronchoconstriction: defined by an FEV1 fall equal to or greater than 10% but lower than 25% in the eucapnic hyperventilatory test.
- Able to securely perform a maximal exercise test (responded 'no' to all questions on the PAR-Q+ questionnaire)
- Able to communicate in English
Exclusion Criteria:
- Diagnosed with any cardiorespiratory or vascular diseases
- Pregnant or potentially pregnant
- Non-smoking
- Lower limb musculoskeletal injury or lower limb limitation to cycle on a bicycle ergometer
- Recent respiratory symptoms or upper tract infection within 4 weeks
- On vitamin (e.g., C or E) supplementation
Sites / Locations
- Environmental Physiology LaboratoryRecruiting
- University of British ColumbiaRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
Ozone (O3) group
Filtered Air
Participants of the experimental group will perform sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer while inhaling 170ppb ozone delivered continuously during each exercise session.
Participants of the sham group will also perform sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer similar to intervention. However, only in this group, the ozone generator will not be activated so that just filtered air will be delivered to the participant while performing each exercise session.