Carbetocin Versus Syntocinon for Prevention of Postpartum Hemorrhage in Cardiac Patients Undergoing Caesarean Section
Adverse Effect of Oxytocic Drugs
About this trial
This is an interventional prevention trial for Adverse Effect of Oxytocic Drugs
Eligibility Criteria
Inclusion Criteria:
- Pregnant female single tone >38 weeks
- Age :18-45 years old.
- patient with ASA III
- Cardiac patients ( mild and moderate mitral stenosis-aortic stenosis valve disease )
Exclusion Criteria:
- Other cardiac conditions (valve regurge, cardiomyopathy, heart failure,severe mitral stenosis, severe aortic stenosis, severe pulmonary hypertension)
- Pregnancy hypertensive disorders (eclampsia,preeclampsia)
- Abnormal placental attachment (accrete,percreta,increta)
- Patients with bleeding disorders
- patient with high risk of postpartum haemorrhage
Sites / Locations
- Faculty of medicine CAIRO UNIVERISTY
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
syntocinon group
carbetocin group
in this group :5 mL syringe containing a bolus of 1 IU of oxytocin and infusion syringe which will be prepared with a 50 mL syringe containing 0.4 IU/mL of oxytocin and infusion rate of 7.5 IU/h will be administrated to the patient after delivery of the fetus shoulder, Additional bolus syringes will be prepared for use as rescue boluses if needed " which will be 5 ml syringe containing 3 IU of oxytocin
in this group :5 mL syringe containing a bolus of 100 mcg of carbetocin and infusion syringe " which will be prepared with a 50 mL syringe containing normal saline will be administrated for the patient after delivery of the fetus shoulder. Additional bolus syringes will be prepared for use as rescue boluses if needed which will be 5 ml syringe containing 100 mcg of carbetocin