Percent reduction in Yale Global Tic Severity Scale -Revised - (YGTSS-R-TTS) of at least 20%
Response to treatment according to YGTSS-R-TTS of at least 20% reduction (compared to baseline)
The responder criterion defined as a more severe Tic, or a greater impact the Tic has on the person's life The Global Severity Score has a range of 0- 100. A higher score the scale suggests a more severe Tic, or a greater impact the Tic has on the person's life.
Percent reduction in Yale Global Tic Severity Scale -Revised - (YGTSS-R-TTS) of at least 30%, 35% and 50%
Response to treatment according to YGTSS-R-TTS responder criterion, defined as a percent reduction in YGTSS-R-TTS of at least 30%, 35% and 50% (compared to baseline) The Global Severity Score has a range of 0- 100. A higher score on the scale suggests a more severe Tic, or a greater impact the Tic has on the person's life.
Absolute change from baseline of YGTSS-R Total Score
Absolute change from baseline of YGTSS-R Total Score, the corresponding subdomain motor and phonic total tic scores, the YGTSS-R Impairment Score, as well as of the combination of the total tic score and the impairment score (YGTSS-R-GS (= YGTSS-R-TTS + YGTSS-R-impairment score).
Percent change from baseline of YGTSS-R Total Score
Percent change from baseline of YGTSS-R Total Score, the corresponding subdomain motor and phonic total tic scores, the YGTSS-R Impairment Score, as well as of the combination of the total tic score and the impairment score (YGTSS-R-GS (= YGTSS-R-TTS + YGTSS-R-impairment score).
Clinical Global Impression-Improvement Score (CGI-I)
Absolute values of the Clinical Global Impression-Improvement Score (CGI-I). CGI is a 7 point scale that ranges from 1 Very much improved to 7 Very much worse
Clinical Global Impression-Severity Score (CGI-S) Absolute result
Absolute change from baseline of Clinical Global Impression-Severity Score (CGI-S).
CGI-S is a 7-point scale that requires the clinician to rate the severity of the patient's illness at the time of assessment, relative to the clinician's past experience with patients who have the same diagnosis.
The range is from 1 Normal, not at all ill to 7 Among the most extremely ill patients
Clinical Global Impression-Severity Score (CGI-S) Percent result
Percent change from baseline of Clinical Global Impression-Severity Score (CGI-S).
CGI-S is a 7-point scale that requires the clinician to rate the severity of the patient's illness at the time of assessment, relative to the clinician's past experience with patients who have the same diagnosis.
The range is from 1 Normal, not at all ill to 7 Among the most extremely ill patients
Total Pre-monitory Urge for Tics Scale (PUTS) Absolute Score
Absolute change from baseline of the total Pre-monitory Urge for Tics Scale (PUTS) Score.
The range of the test is between 9 - 36. A higher score on the scale indicates an extremely high intensity with probable severe impairment.
Total Pre-monitory Urge for Tics Scale (PUTS) Percent Score
Percent change from baseline of the total Pre-monitory Urge for Tics Scale (PUTS) Score.
The range of the test is between 9 - 36. A higher score on the scale indicates an extremely high intensity with probable severe impairment.
Adult Tic Questionnaire (ATQ) Percent Score
Percent change from baseline of the total Adult Tic Questionnaire (ATQ) Score. The Adult Tic Questionnaire (ATQ) Score has a range of 0- 50. A higher score on all scales suggests a more severe Tic, or a greater impact the Tic has on the person's life.
Adult Tic Questionnaire (ATQ) Absolute Score
The absolute change from baseline of the total Adult Tic Questionnaire (ATQ) Score.
The Adult Tic Questionnaire (ATQ) Score has a range of 0- 50. A higher score on all scales suggests a more severe Tic, or a greater impact the Tic has on the person's life.
Changes in Beck Depression Inventory (BDI-II) Percent score.
Percent change from baseline of the Beck Depression Inventory (BDI-II) total score The questionnaire contains about 21 questions, each answer being scored on a scale value of 0 to 3. Higher total scores indicate more severe depressive symptoms.
0-13: minimal depression 14-19: mild depression 20-28: moderate depression 29-63: severe depression
Changes in Beck Depression Inventory (BDI-II) absolute score.
Absolute change from baseline of the Beck Depression Inventory (BDI-II) total score The questionnaire contains about 21 questions, each answer being scored on a scale value of 0 to 3. Higher total scores indicate more severe depressive symptoms.
0-13: minimal depression 14-19: mild depression 20-28: moderate depression 29-63: severe depression
Changes in Yale-Brown Obsessive Compulsive Scale (Y BOCS) absolute score
Absolute change from baseline of the Yale-Brown Obsessive Compulsive Scale (Y BOCS) Total scores on the measure range from 0 to 40, with a score of 0-7 indicating subclinical symptoms, 8-15 mild symptoms, 16-23 moderate symptoms, 24-31 severe symptoms and 32-40 extreme symptoms.
Changes in Yale-Brown Obsessive Compulsive Scale (Y BOCS) Percent score
Percent change from baseline of the Yale-Brown Obsessive Compulsive Scale (Y BOCS) score.
Total scores on the measure range from 0 to 40, with a score of 0-7 indicating subclinical symptoms, 8-15 mild symptoms, 16-23 moderate symptoms, 24-31 severe symptoms and 32-40 extreme symptoms.
Changes in Obsessive-compulsive disorder (OCD) severity Absolute score
Absolute change from baseline of the total Obsessive-compulsive disorder (OCD) severity score.
The range of the test is between 8-15 = Mild OCD; 16-23 = Moderate OCD; 24-31= Severe OCD; 32-40 = Extreme OCD
Changes in Obsessive-compulsive disorder (OCD) severity Percent score
Percent change from baseline of the total Obsessive-compulsive disorder (OCD) severity score.
The range of the test is between 8-15 = Mild OCD; 16-23 = Moderate OCD; 24-31= Severe OCD; 32-40 = Extreme OCD
Changes in Conners' Adult ADHD Rating Scale (CAARS) Absolute score.
Absolute change from baseline of the Conners' Adult ADHD Rating Scale (CAARS) score.
When total score is less than 60 there is no indication of ADHD. A score higher than 60 may indicate ADHD. And a total score higher than 70 means ADHD with more serious symptoms.
Changes in Conners' Adult ADHD Rating Scale (CAARS) Percent score
Percent change from baseline of the Conners' Adult ADHD Rating Scale (CAARS) score When total score is less than 60 there is no indication of ADHD. A score higher than 60 may indicate ADHD. And a total score higher than 70 means ADHD with more serious symptoms.
Changes in Beck Anxiety Inventory (BAI) Absolute scores
Absolute and percent change from baseline of the Beck Anxiety Inventory (BAI) The BAI assessments contains 21 questions, each answer being scored on a scale value of 0 (not at all) to 3 (severely). Higher total scores indicate more severe anxiety symptoms. The standardized cutoffs are: 0-7: Minimal, 8-15: Mild, 16-25: Moderate and 26-63: Severe
Changes in Beck Anxiety Inventory (BAI) percent scores
Percent change from baseline of the Beck Anxiety Inventory (BAI) score. The BAI assessments contains 21 questions, each answer being scored on a scale value of 0 (not at all) to 3 (severely). Higher total scores indicate more severe anxiety symptoms. The standardized cutoffs are: 0-7: Minimal, 8-15: Mild, 16-25: Moderate and 26-63: Severe
Changes in Beck Depression Inventory (BDI) Absolute score
Absolute change from baseline of the total BDI score. When the test is scored, a value of 0 to 3 is assigned for each answer and then the total score is compared to a key to determine the depression's severity. The standard cut-off scores were as follows: 0-9: indicates minimal depression, 10-18: indicates mild depression, 19-29: indicates moderate depression, 30-63: indicates severe depression. Higher total scores indicate more severe depression
Changes in Beck Depression Inventory (BDI) percent score
Percent change from baseline of the total BDI score. When the test is scored, a value of 0 to 3 is assigned for each answer and then the total score is compared to a key to determine the depression's severity. The standard cut-off scores were as follows: 0-9: indicates minimal depression, 10-18: indicates mild depression, 19-29: indicates moderate depression, 30-63: indicates severe depression. Higher total scores indicate more severe depression
Changes in Rage Attacks Questionnaire (RAQ-R) Absolute scores
Absolute change from baseline of the Rage Attacks Questionnaire (RAQ-R) score. The RAQ-R assessments contains 22 questions, each answer being scored on a scale value of 0 (not at all) to 4 (Very powerful, very common). Higher total scores indicate more severe Rage Attacks.
Changes in Rage Attacks Questionnaire (RAQ-R) percent scores
Percent change from baseline of the Rage Attacks Questionnaire (RAQ-R) score. The RAQ-R assessments contains 22 questions, each answer being scored on a scale value of 0 (not at all) to 4 (Very powerful, very common). Higher total scores indicate more severe Rage Attacks.
Changes in Pittsburgh Sleep Quality Index (PSQI) Absolute scores
Absolute change from baseline of the Pittsburgh Sleep Quality Index (PSQI) global score.
PSQI Consisting of 19 items, Each item is weighted on a 0-3 interval scale. The global PSQI score is then calculated by totaling the seven component scores, providing an overall score ranging from 0 to 21, where lower scores denote a healthier sleep quality.
Changes in Pittsburgh Sleep Quality Index (PSQI) Percent scores
Percent change from baseline of the Pittsburgh Sleep Quality Index (PSQI) global score.
PSQI Consisting of 19 items, Each item is weighted on a 0-3 interval scale. The global PSQI score is then calculated by totaling the seven component scores, providing an overall score ranging from 0 to 21, where lower scores denote a healthier sleep quality.
Changes to the Tourette Syndrome-Quality of Life Scale (GTS-QoL) score
Changes from baseline of Tourette Syndrome-Quality of Life Scale (GTS-QoL). GTS-QoL is a 27-item, self-report questionnaire that assesses HR-QoL in young patients with tic disorders, encompassing 4 areas of HR-QoL: psychological, physical/activities of daily living, obsessive-compulsive, and cognitive domains. Each item is rated on a 5-point Likert-type scale and higher scores indicate worse HR-QoL. The instrument includes a Visual Analogue Scale used to express the extent of self-satisfaction about life (higher scores indicate higher satisfaction)
Changes to the 12-item short-form Health Survey (SF-12) score
Changes from baseline of 12-item short-form Health Survey (SF-12). Scores range from 0 to 100, with higher scores indicating better physical and mental health functioning.