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The Effect of Brief Bodyweight Exercise on Acute Glycemic Control in Healthy Inactive Adults

Primary Purpose

Exercise

Status
Completed
Phase
Not Applicable
Locations
Canada
Study Type
Interventional
Intervention
Exercise
Sponsored by
McMaster University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional basic science trial for Exercise focused on measuring Glycemic Control

Eligibility Criteria

18 Years - 35 Years (Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

  • Inactive, defined as not meeting the physical activity targets in the Canadian 24-Hour Movement Guidelines for Adults.
  • Deemed able to safely participate in physical activity and exercise, as determined by the Canadian Society for Exercise Physiology (CSEP) Get Active Questionnaire prescreening tool.

Exclusion Criteria:

- Experiencing a condition that might preclude safe participation in physical activity and exercise, as determined by answering "Yes" to any question on Page 1 of the CSEP Get Active Questionnaire.

Sites / Locations

  • McMaster University

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

No Intervention

Arm Label

Bodyweight Exercise

Non-Exercise Control

Arm Description

A standardized 11-minute bodyweight exercise session that involves a 1-minute warm-up followed by 5, 1-minute bouts of exercise at a self-selected "challenging" pace, interspersed with 1-minute periods of low-intensity exercise for recovery.

An 11-minute period of quiet sitting.

Outcomes

Primary Outcome Measures

24-hour mean glucose
Mean glucose following the bodyweight exercise or control condition

Secondary Outcome Measures

Glycemic variability
Variability in glucose measured following exercise or control
Peak glucose
Peak glucose measured after each meal following exercise or control
2-hour postprandial mean glucose
Mean glucose measured after each meal following exercise or control

Full Information

First Posted
November 22, 2021
Last Updated
July 8, 2022
Sponsor
McMaster University
Collaborators
York University
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1. Study Identification

Unique Protocol Identification Number
NCT05144490
Brief Title
The Effect of Brief Bodyweight Exercise on Acute Glycemic Control in Healthy Inactive Adults
Official Title
The Effect of Brief Bodyweight Exercise on Acute Glycemic Control in Healthy Inactive Adults
Study Type
Interventional

2. Study Status

Record Verification Date
July 2022
Overall Recruitment Status
Completed
Study Start Date
December 6, 2021 (Actual)
Primary Completion Date
June 30, 2022 (Actual)
Study Completion Date
June 30, 2022 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
McMaster University
Collaborators
York University

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
This study will investigate whether an 11-minute bodyweight exercise session can improve short-term glycemic control. Glycemic control refers to the process of how the body regulates blood sugar. The process can be measured in different ways. This study will use a small device called a continuous glucose monitor to measure changes in glucose levels over a 24-hour period. Participants will complete two trials and the investigators will compare glycemic control after the exercise session and a control period that does not involve exercise. Food intake will be controlled such that each participant will consume the same diet in both conditions. This study will help determine whether a single session of bodyweight exercise affects glycemic control.
Detailed Description
This study will investigate whether an 11-minute bodyweight exercise session can improve short-term glycemic control. Glycemic control will be assessed using continuous glucose monitoring for 24 hours following exercise or a control condition that does not involve exercise. The exercise and control periods will be directly supervised by a study investigator. Participants will complete two trials in a randomized, crossover manner separated by 7 days. Food intake will be controlled such that each participant will consume the same diet over the 24-hour period of measurement in both conditions. Standardized meals will be provided to participants prior and following the exercise and control conditions. This study will determine whether a single session of bodyweight exercise affects glycemic control as primarily assessed by mean 24-hour glucose.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Exercise
Keywords
Glycemic Control

7. Study Design

Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Crossover Assignment
Masking
Investigator
Allocation
Randomized
Enrollment
35 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Bodyweight Exercise
Arm Type
Experimental
Arm Description
A standardized 11-minute bodyweight exercise session that involves a 1-minute warm-up followed by 5, 1-minute bouts of exercise at a self-selected "challenging" pace, interspersed with 1-minute periods of low-intensity exercise for recovery.
Arm Title
Non-Exercise Control
Arm Type
No Intervention
Arm Description
An 11-minute period of quiet sitting.
Intervention Type
Other
Intervention Name(s)
Exercise
Intervention Description
A single session of bodyweight exercise
Primary Outcome Measure Information:
Title
24-hour mean glucose
Description
Mean glucose following the bodyweight exercise or control condition
Time Frame
24-hour measurement period
Secondary Outcome Measure Information:
Title
Glycemic variability
Description
Variability in glucose measured following exercise or control
Time Frame
24-hour measurement period
Title
Peak glucose
Description
Peak glucose measured after each meal following exercise or control
Time Frame
2-hour measurement period after each meal
Title
2-hour postprandial mean glucose
Description
Mean glucose measured after each meal following exercise or control
Time Frame
2-hour measurement period after each meal

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
35 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: Inactive, defined as not meeting the physical activity targets in the Canadian 24-Hour Movement Guidelines for Adults. Deemed able to safely participate in physical activity and exercise, as determined by the Canadian Society for Exercise Physiology (CSEP) Get Active Questionnaire prescreening tool. Exclusion Criteria: - Experiencing a condition that might preclude safe participation in physical activity and exercise, as determined by answering "Yes" to any question on Page 1 of the CSEP Get Active Questionnaire.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Martin Gibala, PhD
Organizational Affiliation
McMaster University
Official's Role
Principal Investigator
Facility Information:
Facility Name
McMaster University
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8S4K1
Country
Canada

12. IPD Sharing Statement

Plan to Share IPD
No

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The Effect of Brief Bodyweight Exercise on Acute Glycemic Control in Healthy Inactive Adults

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