Early Diagnosis of Native and Device-associated Meningitis
Bacterial Meningitis, Fungal Meningitis, Implant Infection
About this trial
This is an interventional diagnostic trial for Bacterial Meningitis focused on measuring Pathogen-specific diagnostic biomarker, Cerebrospinal fluid, D-lactate, Device-associated meningitis, Diagnosis of meningitis
Eligibility Criteria
Inclusion criteria:
- patients with suspected (clinical, paraclinical or radiological) native or device-associated meningitis
- age >18 years
- patient signs written consent to participate in the study
Exclusion criteria:
- inability of the patient or family member to consent to the study
- time from puncture to laboratory evaluation> 24 hours
Sites / Locations
- Charité Universitätsmedizin BerlinRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Aseptic Meningitis
Infective meningitis
In all patients cerebrospinal (CSF) fluid will be aspirated following the routine diagnostic procedure. After aspiration CSF will be tested with standard diagnostic tests and experimental diagnostic test (D-lactate). Immediately after aspiration, 0.5-1 ml of cerebrospinal fluid will be transferred into each of the following vials: native vial for conventional culture (agar plate & broth) EDTA vial for the determination of leukocyte count and differential pediatric blood culture bottle (BacTec PedsPlus/F) native vial for biomarker detection (D-Lactate)
In all patients cerebrospinal (CSF) fluid will be aspirated following the routine diagnostic procedure. After aspiration CSF will be tested with standard diagnostic tests and experimental diagnostic test (D-lactate). Immediately after aspiration, 0.5-1 ml of cerebrospinal fluid will be transferred into each of the following vials: native vial for conventional culture (agar plate & broth) EDTA vial for the determination of leukocyte count and differential pediatric blood culture bottle (BacTec PedsPlus/F) native vial for biomarker detection (D-Lactate)