Integrated Rehabilitation in Treating Post-stroke Anxiety (IRTPA)
Post-stroke, Anxiety
About this trial
This is an interventional treatment trial for Post-stroke focused on measuring post-stroke anxiety, integrated rehabilitation, acupuncture, traditional Chinese medicine, repetitive transcranial magnetic stimulation, randomized controlled trial
Eligibility Criteria
Inclusion Criteria:
- Meet the diagnostic criteria of cerebral infarction or cerebral hemorrhage with anxiety disorder, the type of depression and clinical syndrome of liver stagnation transforming into fire;
- Patients with clear consciousness, stable vital signs, ability to understand and cooperate with instructions, barthel index (BI) > 20, FMA (0-95), Mini-mental State Examination (MMSE) meet the following criteria: illiterate > 17, primary school level > 20, secondary school level (including technical secondary school) > 22, and college level (including junior college) > 23 points;
- 25 <= age <= 85 years, male or female;
- First episode of stroke, no personal or family history of mental disability before the stroke;
- Anxiety level as mild or moderate (HAMA scores >= 7 and <= 21);
- Anxiety symptoms occur after the stroke in a clear temporal sequence;
- The course of the PSA is limited to 2 weeks to 36 months after the stroke;
- Participants can understand the study protocol and written informed consent is signed.
Exclusion Criteria:
- Patients with acute brain trauma, brain infection, effusion, or tumor occupation;
- There are intracranial metals and other foreign bodies (such as orthopedic materials, arterial clips, etc.), cardiac pacemakers, deep brain stimulators and other electronic devices;
- Previous seizures, including primary and secondary seizures;
- Patients have severe complications in cardiovascular, liver, kidney or psychiatric history;
- There is a significant cognitive impairment (MMSE: literacy <= 17, primary school level <= 20, secondary school level (including technical secondary school) <= 22, and college level (including junior college) <= 23 points) or hearing impairment, aphasia;
- Coma, dying or chronic illness;
- Patients have taken psychotropic drugs or been treated for anxiety for nearly a month;
- People with unstable vital signs or patients with other mental disorders.
Sites / Locations
- the Third Affiliated Hospital of Zhejiang Chinese Medical UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Integrated rehabilitation group
Standard care group
This group will include 94 patients. On the basis of standard care, patients in this group will receive acupuncture, traditional Chinese medicine, repetitive transcranial magnetic stimulation.
The patients were recommended to take one oral tablet of escitalopram oxalate (10 mg) every morning after a meal for 4 weeks. Internal medicine includes lipid regulation, blood sugar control, anti-hypertension, anticoagulation, and other drugs. Moreover, general duty nursing and motor therapy are also needed.