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Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations (OBERON)

Primary Purpose

Chronic Obstructive Pulmonary Disease (COPD)

Status

Recruiting

Phase

Phase 3

Locations

International

Study Type

Interventional

Intervention

Tozorakimab

Placebo

About this trial

This is an interventional treatment trial for Chronic Obstructive Pulmonary Disease (COPD) focused on measuring Chronic Obstructive Pulmonary Disease, COPD, tozorakimab, exacerbations, ICS, LABA/LAMA

Eligibility Criteria

40 Years - 130 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

Participant must be ≥ 40 years of age and capable of giving signed informed consent.
Documented diagnosis of COPD for at least one year prior to enrolment.
Post BD FEV1/FVC < 0.70 and post-BD FEV1 >20% of predicted normal value.
Documented history of ≥ 2 moderate or ≥ 1 severe COPD exacerbations within 12 months prior to enrolment.
Documented optimized inhaled dual or triple therapy at a stable dose for at least 3 months prior to enrolment.
Smoking history of ≥ 10 pack-years.
CAT total score ≥10, with each of the phlegm (sputum) and cough items with a score ≥ 2.

Exclusion Criteria:

Clinically important pulmonary disease other than COPD.
Radiological findings suggestive of a respiratory disease other than COPD that is contributing to the participant's respiratory symptoms.
Current diagnosis of asthma, prior history of asthma, or asthma-COPD overlap. Childhood history of asthma is allowed and defined as asthma diagnosed and resolved before the age of 18.
Any unstable disorder, including, but not limited to, cardiovascular, gastrointestinal, hepatic, renal, neurological, musculoskeletal, infectious, endocrine, metabolic, haematological, psychiatric disorder, major physical and/or cognitive impairment that could affect safety, study findings or participants ability to complete the study.
COPD exacerbation, within 2 weeks prior to randomization, that was treated with systemic corticosteroids and/or antibiotics, and/or led to hospitalization.
Active significant infection within the 4 weeks prior to randomization, pneumonia within 6 weeks prior to randomization, or medical condition that predisposes the participant to infection.
Suspicion of, or confirmed, ongoing SARS-CoV-2 infection.
Significant COVID-19 illness within the 6 months prior to enrolment.
Unstable cardiovascular disorder.
Diagnosis of cor pulmonale, pulmonary arterial hypertension and/or right ventricular failure.
History of known immunodeficiency disorder, including a positive test for HIV-1 or HIV 2.
History of positive test or treatment for hepatitis B or hepatitis C (except for cured hepatitis C).
Evidence of active liver disease, including jaundice during screening.
Malignancy, current or within the past 5 years, except for adequately treated non-invasive basal cell and squamous cell carcinoma of the skin and cervical carcinoma-in-situ treated with apparent success more than one year prior to enrolment. Suspected malignancy or undefined neoplasms.
Participants who have evidence of active TB.
Participants that have previously received tozorakimab.
Any clinically significant abnormal findings in physical examination, vital signs, ECG, or laboratory testing during the screening period, which in the opinion of the investigator may put the participant at risk because of their participation in the study, or may influence the results of the study, or the participant's ability to complete the entire duration of the study.
Active vaping of any products within the 6 months prior to randomization and during the study.

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Placebo Comparator

Arm Label

Tozorakimab Dose 1

Tozorakimab Dose 2

Placebo

Arm Description

Dosing subcutaneously tozorakimab Dose 1 and placebo

Dosing subcutaneously tozorakimab Dose 2

Dosing subcutaneously with equivalent volume to tozorakimab

Outcomes

Primary Outcome Measures

Annualized rate of moderate to severe COPD exacerbations in participants who are former smokers.

The primary endpoint will be assessed first in the primary population (former smokers with symptomatic COPD and a history of exacerbations, on optimised treatment with maintenance inhaled therapy [triple therapy, or dual therapy if triple is not considered appropriate]) and then assessed in the overall population of participants.

Secondary Outcome Measures

Annualized rate of moderate to severe COPD exacerbations in former or current smokers.

The annualized rate will be assessed in the overall population of participants including current and former smokers with symptomatic COPD and history of exacerbations, on optimised treatment with maintenance inhaled therapy.

Time to first moderate to severe COPD exacerbation in former smokers.

To explore the extent to which treatment with each dose of tozorakimab delays the time to first exacerbation compared with placebo in former smokers.

Mean change from baseline in pre-BD, pre-dose trough FEV1 (mL) in former smokers.

Change from baseline in pre-bronchodilator, pre dose trough FEV1 (mL) in former smokers.

Mean change from baseline in pre-BD, pre-dose trough FEV1 (mL) in the overall population of current and former smokers.

Change from baseline in pre-bronchodilator, pre dose trough FEV1 (mL) in the overall population of current and former smokers.

Percentage of responders achieving MCID in E-RS:COPD total score in former smokers.

Responder analyses for E-RS:COPD total score at Week 52 based upon a ≥ 2 point improvement (decrease) from baseline in former smokers.

Percentage of responders achieving MCID in E-RS:COPD total score in the overall population of current and former smokers.

Responder analyses for E-RS:COPD total score at Week 52 based upon a ≥ 2 point improvement (decrease) from baseline in the overall population of current and former smokers.

Mean change from baseline in E-RS:COPD total score in former smokers.

Difference in mean change in E-RS:COPD total score from baseline in former smokers.

Mean change from baseline in E-RS:COPD total score in the overall population of current and former smokers.

Difference in mean change in E-RS:COPD total score from baseline in the overall population of current and former smokers.

Percentage of responders achieving MCID in SGRQ total score in former smokers.

Percentage of participants with a decrease in SGRQ total score of ≥ 4 points from baseline in former smokers.

Percentage of responders achieving MCID in SGRQ total score in the overall population of current and former smokers.

Percentage of participants with a decrease in SGRQ total score of ≥ 4 points from baseline in the overall population of current and former smokers.

Mean change from baseline in SGRQ total score from in former smokers.

Difference in mean change from baseline in SGRQ total score in former smokers.

Mean change from baseline in SGRQ total score from in the overall population of current and former smokers

Difference in mean change from baseline in SGRQ total score in the overall population of current and former smokers.

Time to first severe COPD exacerbation in former smokers.

To evaluate hazard ratio of first severe COPD exacerbation in former smokers.

Annualized rate of severe COPD exacerbations in former smokers.

The rate ratio of severe COPD exacerbations will be assessed in former smokers.

Change from baseline in CAT total score.

Analyses of change from baseline in CAT total score in former smokers.

Percentage of participants with a decrease in CAT total score in former smokers.

Proportion of participants achieving MCID in CAT total score, a decrease in CAT total score of ≥ 2 points from baseline in former smokers.

Proportion of participants having ≥ 1 healthcare resource utilization type in former smokers.

Annualized rate of healthcare resource utilization in former smokers.

The change from baseline in mean number of puffs per day in rescue use in former smokers.

Difference in mean number of puffs per day from baseline.

Trough serum concentrations of tozorakimab.

Pharmacokinetics: concentrations of tozorakimab in trough serum.

Presence of anti-drug antibodies.

Immunogenicity: presence of tozorakimab anti-drug antibodies in blood serum.

Full Information

NCT ID

NCT05166889

First Posted

December 9, 2021

Last Updated

October 12, 2023

Sponsor

AstraZeneca

1. Study Identification

Unique Protocol Identification Number

NCT05166889

Brief Title

Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations

Acronym

OBERON

Official Title

A Phase III, Multicentre, Randomised, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Two Dose Regimens of Tozorakimab in Participants With Symptomatic Chronic Obstructive Pulmonary Disease (COPD) With a History of COPD Exacerbations (OBERON)

Study Type

Interventional

2. Study Status

Record Verification Date

October 2023

Overall Recruitment Status

Recruiting

Study Start Date

January 3, 2022 (Actual)

Primary Completion Date

June 4, 2025 (Anticipated)

Study Completion Date

August 27, 2025 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

AstraZeneca

4. Oversight

Studies a U.S. FDA-regulated Drug Product

Yes

Studies a U.S. FDA-regulated Device Product

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

The purpose of this Phase III study is to evaluate the efficacy and safety of tozorakimab Dose 1 and Dose 2 administered subcutaneously (SC) in adult participants with symptomatic COPD and history of ≥ 2 moderate or ≥ 1 severe exacerbation of COPD in the previous 12 months. Participants should be receiving optimised treatment with maintenance inhaled therapy (ICS/LABA/LAMA triple therapy, or dual therapy if triple is not considered appropriate) in stable doses throughout at least 3 months prior to enrolment.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Chronic Obstructive Pulmonary Disease (COPD)

Keywords

Chronic Obstructive Pulmonary Disease, COPD, tozorakimab, exacerbations, ICS, LABA/LAMA

7. Study Design

Primary Purpose

Treatment

Study Phase

Phase 3

Interventional Study Model

Parallel Assignment

Masking

ParticipantCare ProviderInvestigator

Masking Description

unblinded administrator/pharmacist

Allocation

Randomized

Enrollment

1060 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title

Tozorakimab Dose 1

Arm Type

Experimental

Arm Description

Dosing subcutaneously tozorakimab Dose 1 and placebo

Arm Title

Tozorakimab Dose 2

Arm Type

Experimental

Arm Description

Dosing subcutaneously tozorakimab Dose 2

Arm Title

Placebo

Arm Type

Placebo Comparator

Arm Description

Dosing subcutaneously with equivalent volume to tozorakimab

Intervention Type

Drug

Intervention Name(s)

Tozorakimab

Intervention Description

Administered subcutaneously tozorakimab Dose 1 and placebo through Week 52.

Intervention Type

Drug

Intervention Name(s)

Tozorakimab

Intervention Description

Administered subcutaneously tozorakimab Dose 2 through Week 52.

Intervention Type

Drug

Intervention Name(s)

Placebo

Intervention Description

Placebo administered subcutaneously, equivalent volume to tozorakimab through week 52.

Primary Outcome Measure Information:

Title

Annualized rate of moderate to severe COPD exacerbations in participants who are former smokers.

Description

Time Frame

over 52 weeks

Secondary Outcome Measure Information:

Title

Annualized rate of moderate to severe COPD exacerbations in former or current smokers.

Description

Time Frame

over 52 weeks

Title

Time to first moderate to severe COPD exacerbation in former smokers.

Description

To explore the extent to which treatment with each dose of tozorakimab delays the time to first exacerbation compared with placebo in former smokers.

Time Frame

over 52 weeks

Title

Mean change from baseline in pre-BD, pre-dose trough FEV1 (mL) in former smokers.

Description

Change from baseline in pre-bronchodilator, pre dose trough FEV1 (mL) in former smokers.

Time Frame

Week 52, or over 52 weeks

Title

Mean change from baseline in pre-BD, pre-dose trough FEV1 (mL) in the overall population of current and former smokers.

Description

Change from baseline in pre-bronchodilator, pre dose trough FEV1 (mL) in the overall population of current and former smokers.

Time Frame

Week 52, or over 52 weeks

Title

Percentage of responders achieving MCID in E-RS:COPD total score in former smokers.

Description

Responder analyses for E-RS:COPD total score at Week 52 based upon a ≥ 2 point improvement (decrease) from baseline in former smokers.

Time Frame

Week 52

Title

Percentage of responders achieving MCID in E-RS:COPD total score in the overall population of current and former smokers.

Description

Responder analyses for E-RS:COPD total score at Week 52 based upon a ≥ 2 point improvement (decrease) from baseline in the overall population of current and former smokers.

Time Frame

Week 52

Title

Mean change from baseline in E-RS:COPD total score in former smokers.

Description

Difference in mean change in E-RS:COPD total score from baseline in former smokers.

Time Frame

over 52 weeks

Title

Mean change from baseline in E-RS:COPD total score in the overall population of current and former smokers.

Description

Difference in mean change in E-RS:COPD total score from baseline in the overall population of current and former smokers.

Time Frame

over 52 weeks

Title

Percentage of responders achieving MCID in SGRQ total score in former smokers.

Description

Percentage of participants with a decrease in SGRQ total score of ≥ 4 points from baseline in former smokers.

Time Frame

Week 52

Title

Percentage of responders achieving MCID in SGRQ total score in the overall population of current and former smokers.

Description

Percentage of participants with a decrease in SGRQ total score of ≥ 4 points from baseline in the overall population of current and former smokers.

Time Frame

Week 52

Title

Mean change from baseline in SGRQ total score from in former smokers.

Description

Difference in mean change from baseline in SGRQ total score in former smokers.

Time Frame

over 52 weeks

Title

Mean change from baseline in SGRQ total score from in the overall population of current and former smokers

Description

Difference in mean change from baseline in SGRQ total score in the overall population of current and former smokers.

Time Frame

over 52 weeks

Title

Time to first severe COPD exacerbation in former smokers.

Description

To evaluate hazard ratio of first severe COPD exacerbation in former smokers.

Time Frame

over 52 weeks

Title

Annualized rate of severe COPD exacerbations in former smokers.

Description

The rate ratio of severe COPD exacerbations will be assessed in former smokers.

Time Frame

over 52 weeks

Title

Change from baseline in CAT total score.

Description

Analyses of change from baseline in CAT total score in former smokers.

Time Frame

Week 52

Title

Percentage of participants with a decrease in CAT total score in former smokers.

Description

Proportion of participants achieving MCID in CAT total score, a decrease in CAT total score of ≥ 2 points from baseline in former smokers.

Time Frame

Week 52

Title

Proportion of participants having ≥ 1 healthcare resource utilization type in former smokers.

Description

Proportion of participants having ≥ 1 healthcare resource utilization type in former smokers.

Time Frame

over 52 weeks

Title

Annualized rate of healthcare resource utilization in former smokers.

Description

Annualized rate of healthcare resource utilization in former smokers.

Time Frame

over 52 weeks

Title

The change from baseline in mean number of puffs per day in rescue use in former smokers.

Description

Difference in mean number of puffs per day from baseline.

Time Frame

over 52 weeks

Title

Trough serum concentrations of tozorakimab.

Description

Pharmacokinetics: concentrations of tozorakimab in trough serum.

Time Frame

over 52 weeks

Title

Presence of anti-drug antibodies.

Description

Immunogenicity: presence of tozorakimab anti-drug antibodies in blood serum.

Time Frame

over 60 weeks

10. Eligibility

Sex

All

Minimum Age & Unit of Time

40 Years

Maximum Age & Unit of Time

130 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Participant must be ≥ 40 years of age and capable of giving signed informed consent. Documented diagnosis of COPD for at least one year prior to enrolment. Post BD FEV1/FVC < 0.70 and post-BD FEV1 >20% of predicted normal value. Documented history of ≥ 2 moderate or ≥ 1 severe COPD exacerbations within 12 months prior to enrolment. Documented optimized inhaled dual or triple therapy at a stable dose for at least 3 months prior to enrolment. Smoking history of ≥ 10 pack-years. CAT total score ≥10, with each of the phlegm (sputum) and cough items with a score ≥ 2. Exclusion Criteria: Clinically important pulmonary disease other than COPD. Radiological findings suggestive of a respiratory disease other than COPD that is significantly contributing to the participant's respiratory symptoms. Current diagnosis of asthma, prior history of asthma, or asthma-COPD overlap. Childhood history of asthma is allowed and defined as asthma diagnosed and resolved before the age of 18. Any unstable disorder, including, but not limited to, cardiovascular, gastrointestinal, hepatic, renal, neurological, musculoskeletal, infectious, endocrine, metabolic, haematological, psychiatric disorder, major physical and/or cognitive impairment that could affect safety, study findings or participants ability to complete the study. COPD exacerbation, within 2 weeks prior to randomization, that was treated with systemic corticosteroids and/or antibiotics, and/or led to hospitalization. Active significant infection within the 4 weeks prior to randomization, pneumonia within 6 weeks prior to randomization, or medical condition that predisposes the participant to infection. Suspicion of, or confirmed, ongoing SARS-CoV-2 infection. Significant COVID-19 illness within the 6 months prior to enrolment. Unstable cardiovascular disorder. Diagnosis of cor pulmonale, pulmonary arterial hypertension and/or right ventricular failure. History of known immunodeficiency disorder, including a positive test for HIV-1 or HIV 2. History of positive test or treatment for hepatitis B or hepatitis C (except for cured hepatitis C) Evidence of active liver disease, including jaundice during screening. Malignancy, current or within the past 5 years, except for adequately treated non-invasive basal cell and squamous cell carcinoma of the skin and cervical carcinoma-in-situ treated with apparent success more than one year prior to enrolment. Suspected malignancy or undefined neoplasms. Participants who have evidence of active TB. Participants that have previously received tozorakimab. Any clinically significant abnormal findings in physical examination, vital signs, ECG, or laboratory testing during the screening period, which in the opinion of the investigator may put the participant at risk because of their participation in the study, or may influence the results of the study, or the participant's ability to complete the entire duration of the study. Active vaping of any products or using smoked marijuana within the 6 months prior to randomization and during the study.

Central Contact Person:

First Name & Middle Initial & Last Name or Official Title & Degree

AstraZeneca Clinical Study Information Center

Phone

1-877-240-9479

information.center@astrazeneca.com

Facility Information:

Facility Name

Research Site

City

Huntsville

State/Province

Alabama

ZIP/Postal Code

35801

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Mobile

State/Province

Alabama

ZIP/Postal Code

36608

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Montgomery

State/Province

Alabama

ZIP/Postal Code

36106

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Tempe

State/Province

Arizona

ZIP/Postal Code

85283

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bakersfield

State/Province

California

ZIP/Postal Code

93301

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Palm Springs

State/Province

California

ZIP/Postal Code

92262

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Sacramento

State/Province

California

ZIP/Postal Code

95821

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Boynton Beach

State/Province

Florida

ZIP/Postal Code

33435

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Jacksonville

State/Province

Florida

ZIP/Postal Code

32209

Country

United States

Individual Site Status

Suspended

Facility Name

Research Site

City

Kissimmee

State/Province

Florida

ZIP/Postal Code

34744

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ormond Beach

State/Province

Florida

ZIP/Postal Code

32174

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Plantation

State/Province

Florida

ZIP/Postal Code

33324

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Brookhaven

State/Province

Georgia

ZIP/Postal Code

30329

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Meridian

State/Province

Idaho

ZIP/Postal Code

83642

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60608

Country

United States

Individual Site Status

Suspended

Facility Name

Research Site

City

Evanston

State/Province

Illinois

ZIP/Postal Code

60201

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Evergreen Park

State/Province

Illinois

ZIP/Postal Code

60805

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Normal

State/Province

Illinois

ZIP/Postal Code

61761

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Iowa City

State/Province

Iowa

ZIP/Postal Code

52242

Country

United States

Individual Site Status

Suspended

Facility Name

Research Site

City

Kansas City

State/Province

Kansas

ZIP/Postal Code

66104

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Baton Rouge

State/Province

Louisiana

ZIP/Postal Code

70816

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Zachary

State/Province

Louisiana

ZIP/Postal Code

70791

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Baltimore

State/Province

Maryland

ZIP/Postal Code

21224

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Rochester

State/Province

Minnesota

ZIP/Postal Code

55905

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63110

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63141

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Missoula

State/Province

Montana

ZIP/Postal Code

59808

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Brick

State/Province

New Jersey

ZIP/Postal Code

08724

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Guttenberg

State/Province

New Jersey

ZIP/Postal Code

07093

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Albuquerque

State/Province

New Mexico

ZIP/Postal Code

87131

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Bronx

State/Province

New York

ZIP/Postal Code

10455

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Buffalo

State/Province

New York

ZIP/Postal Code

14215

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Hawthorne

State/Province

New York

ZIP/Postal Code

10532

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

New Hyde Park

State/Province

New York

ZIP/Postal Code

11042

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

New York

State/Province

New York

ZIP/Postal Code

10037

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

North Massapequa

State/Province

New York

ZIP/Postal Code

11758

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Schenectady

State/Province

New York

ZIP/Postal Code

12304

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Charlotte

State/Province

North Carolina

ZIP/Postal Code

28277

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Durham

State/Province

North Carolina

ZIP/Postal Code

27710

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Gastonia

State/Province

North Carolina

ZIP/Postal Code

28054

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Raleigh

State/Province

North Carolina

ZIP/Postal Code

27607

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Fargo

State/Province

North Dakota

ZIP/Postal Code

58104

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

DuBois

State/Province

Pennsylvania

ZIP/Postal Code

15801

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hershey

State/Province

Pennsylvania

ZIP/Postal Code

17033

Country

United States

Individual Site Status

Suspended

Facility Name

Research Site

City

Pittsburgh

State/Province

Pennsylvania

ZIP/Postal Code

15213

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sayre

State/Province

Pennsylvania

ZIP/Postal Code

18840

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Rapid City

State/Province

South Dakota

ZIP/Postal Code

57702

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Franklin

State/Province

Tennessee

ZIP/Postal Code

37067

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nashville

State/Province

Tennessee

ZIP/Postal Code

37232

Country

United States

Individual Site Status

Suspended

Facility Name

Research Site

City

Fort Worth

State/Province

Texas

ZIP/Postal Code

76107

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Houston

State/Province

Texas

ZIP/Postal Code

77022

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kingwood

State/Province

Texas

ZIP/Postal Code

77339

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sherman

State/Province

Texas

ZIP/Postal Code

75092

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Salt Lake City

State/Province

Utah

ZIP/Postal Code

84108

Country

United States

Individual Site Status

Suspended

Facility Name

Research Site

City

Burlington

State/Province

Vermont

ZIP/Postal Code

05401

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Tacoma

State/Province

Washington

ZIP/Postal Code

98405

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Charleston

State/Province

West Virginia

ZIP/Postal Code

25304

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Marshfield

State/Province

Wisconsin

ZIP/Postal Code

54449

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Buenos Aires

ZIP/Postal Code

C1121 ABE

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Buenos Aires

ZIP/Postal Code

C1414AIF

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Caba

ZIP/Postal Code

C1425BEN

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Córdoba

ZIP/Postal Code

X5003DCE

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Florencio Varela

ZIP/Postal Code

1888

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Mar del Plata

ZIP/Postal Code

7600

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Mar del Plata

ZIP/Postal Code

B7600GWV

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Mendoza

ZIP/Postal Code

M5500GIP

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Quilmes

ZIP/Postal Code

B1878FNR

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ranelagh

ZIP/Postal Code

1886

Country

Argentina

Individual Site Status

Withdrawn

Facility Name

Research Site

City

San Fernando

ZIP/Postal Code

B1646EBJ

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

San Miguel de Tucuman

ZIP/Postal Code

4000

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bruxelles

ZIP/Postal Code

1000

Country

Belgium

Individual Site Status

Recruiting

Facility Name

Research Site

City

Gent

ZIP/Postal Code

9000

Country

Belgium

Individual Site Status

Recruiting

Facility Name

Research Site

City

Leuven

ZIP/Postal Code

3000

Country

Belgium

Individual Site Status

Recruiting

Facility Name

Research Site

City

Liege

ZIP/Postal Code

4000

Country

Belgium

Individual Site Status

Recruiting

Facility Name

Research Site

City

Namur

ZIP/Postal Code

5101

Country

Belgium

Individual Site Status

Recruiting

Facility Name

Research Site

City

Dupnitsa

ZIP/Postal Code

2600

Country

Bulgaria

Individual Site Status

Recruiting

Facility Name

Research Site

City

Haskovo

ZIP/Postal Code

6305

Country

Bulgaria

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kozloduy

ZIP/Postal Code

3320

Country

Bulgaria

Individual Site Status

Recruiting

Facility Name

Research Site

City

Lovech

ZIP/Postal Code

5500

Country

Bulgaria

Individual Site Status

Recruiting

Facility Name

Research Site

City

Petrich

ZIP/Postal Code

2850

Country

Bulgaria

Individual Site Status

Recruiting

Facility Name

Research Site

City

Pleven

ZIP/Postal Code

5800

Country

Bulgaria

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ruse

ZIP/Postal Code

7002

Country

Bulgaria

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sliven

ZIP/Postal Code

8800

Country

Bulgaria

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sofia

ZIP/Postal Code

1000

Country

Bulgaria

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sofia

ZIP/Postal Code

1154

Country

Bulgaria

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Sofia

ZIP/Postal Code

1606

Country

Bulgaria

Individual Site Status

Recruiting

Facility Name

Research Site

City

Troyan

ZIP/Postal Code

5600

Country

Bulgaria

Individual Site Status

Recruiting

Facility Name

Research Site

City

Varna

ZIP/Postal Code

9000

Country

Bulgaria

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Vratsa

ZIP/Postal Code

3000

Country

Bulgaria

Individual Site Status

Recruiting

Facility Name

Research Site

City

Calgary

State/Province

Alberta

ZIP/Postal Code

T3E 7M8

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Edmonton

State/Province

Alberta

ZIP/Postal Code

T5A 4L8

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sherwood Park

State/Province

Alberta

ZIP/Postal Code

T8L 0N2

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kamloops

State/Province

British Columbia

ZIP/Postal Code

V2C 5T1

Country

Canada

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Kelowna

State/Province

British Columbia

ZIP/Postal Code

V1Y 4N7

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ajax

State/Province

Ontario

ZIP/Postal Code

L1S 2J5

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Barrie

State/Province

Ontario

ZIP/Postal Code

L4N 1B3

Country

Canada

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Guelph

State/Province

Ontario

ZIP/Postal Code

N1H 6J2

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hamilton

State/Province

Ontario

ZIP/Postal Code

L8S 4K1

Country

Canada

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Markham

State/Province

Ontario

ZIP/Postal Code

L3T 0C8

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Stouffville

State/Province

Ontario

ZIP/Postal Code

L4A 1H2

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Winchester

State/Province

Ontario

ZIP/Postal Code

K0C 2K0

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Montreal

State/Province

ZIP/Postal Code

H3T 1E2

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Terrebonne

State/Province

Quebec

ZIP/Postal Code

J6V 2H2

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Quebec

ZIP/Postal Code

G1G 3Y8

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Quebec

ZIP/Postal Code

G1V 4G5

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Brno

ZIP/Postal Code

625 00

Country

Czechia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Broumov

ZIP/Postal Code

55001

Country

Czechia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Jihlava

ZIP/Postal Code

586 33

Country

Czechia

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Jindrichuv Hradec

ZIP/Postal Code

377 01

Country

Czechia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Liberec 1

ZIP/Postal Code

460 63

Country

Czechia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Mlada Boleslav

ZIP/Postal Code

293 01

Country

Czechia

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Olomouc

ZIP/Postal Code

779 00

Country

Czechia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Rokycany

ZIP/Postal Code

337 22

Country

Czechia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Aarhus

ZIP/Postal Code

8200

Country

Denmark

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Hvidovre

ZIP/Postal Code

2650

Country

Denmark

Individual Site Status

Recruiting

Facility Name

Research Site

City

København NV

ZIP/Postal Code

2400

Country

Denmark

Individual Site Status

Recruiting

Facility Name

Research Site

City

Næstved

ZIP/Postal Code

4700

Country

Denmark

Individual Site Status

Recruiting

Facility Name

Research Site

City

Roskilde

ZIP/Postal Code

4000

Country

Denmark

Individual Site Status

Recruiting

Facility Name

Research Site

City

Vejle

ZIP/Postal Code

7100

Country

Denmark

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ålborg

ZIP/Postal Code

9000

Country

Denmark

Individual Site Status

Recruiting

Facility Name

Research Site

City

Helsinki

ZIP/Postal Code

00290

Country

Finland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hämeenlinna

ZIP/Postal Code

13530

Country

Finland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kuopio

ZIP/Postal Code

70210

Country

Finland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Tampere

ZIP/Postal Code

33520

Country

Finland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Turku

ZIP/Postal Code

20100

Country

Finland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Turku

ZIP/Postal Code

20520

Country

Finland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Baja

ZIP/Postal Code

6500

Country

Hungary

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Budapest

ZIP/Postal Code

1036

Country

Hungary

Individual Site Status

Recruiting

Facility Name

Research Site

City

Budapest

ZIP/Postal Code

1106

Country

Hungary

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Budapest

ZIP/Postal Code

1121

Country

Hungary

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Debrecen

ZIP/Postal Code

4032

Country

Hungary

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Edelény

ZIP/Postal Code

3780

Country

Hungary

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Encs

ZIP/Postal Code

3860

Country

Hungary

Individual Site Status

Recruiting

Facility Name

Research Site

City

Gyöngyös

ZIP/Postal Code

3200

Country

Hungary

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Mosonmagyaróvár

ZIP/Postal Code

9200

Country

Hungary

Individual Site Status

Recruiting

Facility Name

Research Site

City

Százhalombatta

ZIP/Postal Code

2440

Country

Hungary

Individual Site Status

Recruiting

Facility Name

Research Site

City

Székesfehérvár

ZIP/Postal Code

8000

Country

Hungary

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Ahmedabad

ZIP/Postal Code

382415

Country

India

Individual Site Status

Recruiting

Facility Name

Research Site

City

Belagavi

ZIP/Postal Code

590010

Country

India

Individual Site Status

Recruiting

Facility Name

Research Site

City

Coimbatore

ZIP/Postal Code

641028

Country

India

Individual Site Status

Recruiting

Facility Name

Research Site

City

Dehradun

ZIP/Postal Code

248001

Country

India

Individual Site Status

Recruiting

Facility Name

Research Site

City

Jaipur

ZIP/Postal Code

302039

Country

India

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kolkatta

ZIP/Postal Code

700027

Country

India

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Mohali

ZIP/Postal Code

160062

Country

India

Individual Site Status

Terminated

Facility Name

Research Site

City

Nagpur

ZIP/Postal Code

440012

Country

India

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nashik

ZIP/Postal Code

422007

Country

India

Individual Site Status

Recruiting

Facility Name

Research Site

City

New Delhi

ZIP/Postal Code

110017

Country

India

Individual Site Status

Withdrawn

Facility Name

Research Site

City

New Delhi

ZIP/Postal Code

110029

Country

India

Individual Site Status

Recruiting

Facility Name

Research Site

City

Thane

ZIP/Postal Code

401107

Country

India

Individual Site Status

Recruiting

Facility Name

Research Site

City

Asahikawa-shi

ZIP/Postal Code

078-8510

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bunkyo-ku

ZIP/Postal Code

113-8519

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chikushino-shi

ZIP/Postal Code

818-8502

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chuo-ku

ZIP/Postal Code

103-0022

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chuo-ku

ZIP/Postal Code

103-0028

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Fujieda-shi

ZIP/Postal Code

426-8677

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Fukuoka-shi

ZIP/Postal Code

819-8555

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hamamatsu-shi

ZIP/Postal Code

430-8525

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hamamatsu-shi

ZIP/Postal Code

431-3192

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Himeji-shi

ZIP/Postal Code

672-8064

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hiroshima-shi

ZIP/Postal Code

730-0822

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hiroshima-shi

ZIP/Postal Code

734-8530

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Iizuka-shi

ZIP/Postal Code

820-8505

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Itabashi-ku

ZIP/Postal Code

173-8610

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Iwata-shi

ZIP/Postal Code

438-8550

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Izumi-shi

ZIP/Postal Code

594-0073

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Joyo-shi

ZIP/Postal Code

610-0113

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kagoshima-shi

ZIP/Postal Code

890-8520

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kakogawa-shi

ZIP/Postal Code

675-8611

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kamogawa-shi

ZIP/Postal Code

296-0041

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kanazawa-shi

ZIP/Postal Code

920-8530

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kanazawa-shi

ZIP/Postal Code

920-8650

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kawachinagano-shi

ZIP/Postal Code

586-8521

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kawasaki-shi

ZIP/Postal Code

216-8511

Country

Japan

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Kitakyusyu-shi

ZIP/Postal Code

806-8501

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kitakyusyu

ZIP/Postal Code

802-0052

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kiyose-shi

ZIP/Postal Code

204-8585

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kobe-shi

ZIP/Postal Code

651-0072

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kofu-shi

ZIP/Postal Code

400-8506

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Koga-shi

ZIP/Postal Code

811-3195

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kokubunji-shi

ZIP/Postal Code

185-0014

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Koto-ku

ZIP/Postal Code

136-0075

Country

Japan

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Matsusaka-shi

ZIP/Postal Code

515-8544

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Meguro-ku

ZIP/Postal Code

153-8515

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Mitaka-shi

ZIP/Postal Code

181-8611

Country

Japan

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Miyazaki-shi

ZIP/Postal Code

880-8510

Country

Japan

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Mizunami-shi

ZIP/Postal Code

509-6134

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nagaoka-shi

ZIP/Postal Code

940-8621

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nagoya-shi

ZIP/Postal Code

457-0866

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nagoya-shi

ZIP/Postal Code

460-0001

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Narita-shi

ZIP/Postal Code

286-8520

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Niigata-shi

ZIP/Postal Code

950-1197

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nishinomiya-shi

ZIP/Postal Code

663-8501

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Obihiro

ZIP/Postal Code

080-0017

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Okayama-shi

ZIP/Postal Code

702-8055

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Okayama

ZIP/Postal Code

700-8558

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Osaka-shi

ZIP/Postal Code

531-0073

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Osaka-shi

ZIP/Postal Code

543-8555

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Osaka-shi

ZIP/Postal Code

545-8586

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sakai-shi

ZIP/Postal Code

590-0064

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sakaide-shi

ZIP/Postal Code

762-0031

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Saku-shi

ZIP/Postal Code

385-0051

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sapporo-shi

ZIP/Postal Code

062-0931

Country

Japan

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Sendai-Shi

ZIP/Postal Code

984-0042

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Seto-shi

ZIP/Postal Code

489-8642

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shinjuku-ku

ZIP/Postal Code

162-8655

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shizuoka-shi

ZIP/Postal Code

420-8630

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Tachikawa-shi

ZIP/Postal Code

190-0014

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Takamatsu-shi

ZIP/Postal Code

760-0018

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Toshima-ku

ZIP/Postal Code

170-0003

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Toyama-shi

ZIP/Postal Code

930-8550

Country

Japan

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Toyonaka-shi

ZIP/Postal Code

560-8552

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Wakayama-shi

ZIP/Postal Code

640-8505

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Yamagata-shi

ZIP/Postal Code

990-9585

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Yanagawa-shi

ZIP/Postal Code

832-0059

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Yokohama-shi

ZIP/Postal Code

221-0855

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Yokohama-shi

ZIP/Postal Code

223-0059

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Yokohama-shi

ZIP/Postal Code

232-0024

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Daegu

ZIP/Postal Code

42415

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Incheon

ZIP/Postal Code

21431

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Jeonju-si

ZIP/Postal Code

54907

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Seoul

ZIP/Postal Code

03722

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Seoul

ZIP/Postal Code

05030

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Seoul

ZIP/Postal Code

05505

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Seoul

ZIP/Postal Code

06591

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Seoul

ZIP/Postal Code

07061

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Benito Juarez

ZIP/Postal Code

03650

Country

Mexico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chihuahua

ZIP/Postal Code

31000

Country

Mexico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Guadalajara

ZIP/Postal Code

44100

Country

Mexico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Guadalajara

ZIP/Postal Code

44200

Country

Mexico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Mexico City

ZIP/Postal Code

0 3100

Country

Mexico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Monterrey

ZIP/Postal Code

64460

Country

Mexico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Morelia

ZIP/Postal Code

58000

Country

Mexico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Mérida

ZIP/Postal Code

97070

Country

Mexico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Oaxaca

ZIP/Postal Code

68020

Country

Mexico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Veracruz

ZIP/Postal Code

91910

Country

Mexico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Alkmaar

ZIP/Postal Code

1815 JD

Country

Netherlands

Individual Site Status

Recruiting

Facility Name

Research Site

City

Eindhoven

ZIP/Postal Code

5623EJ

Country

Netherlands

Individual Site Status

Recruiting

Facility Name

Research Site

City

Groningen

ZIP/Postal Code

9713 GZ

Country

Netherlands

Individual Site Status

Recruiting

Facility Name

Research Site

City

Harderwijk

ZIP/Postal Code

3844 DG

Country

Netherlands

Individual Site Status

Recruiting

Facility Name

Research Site

City

Heerlen

ZIP/Postal Code

6419 PC

Country

Netherlands

Individual Site Status

Recruiting

Facility Name

Research Site

City

Zutphen

ZIP/Postal Code

7207 AE

Country

Netherlands

Individual Site Status

Recruiting

Facility Name

Research Site

City

Zwolle

ZIP/Postal Code

8025 AB

Country

Netherlands

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bergen

ZIP/Postal Code

5021

Country

Norway

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bodø

ZIP/Postal Code

8092

Country

Norway

Individual Site Status

Recruiting

Facility Name

Research Site

City

Levanger

ZIP/Postal Code

7600

Country

Norway

Individual Site Status

Terminated

Facility Name

Research Site

City

Lørenskog

ZIP/Postal Code

1478

Country

Norway

Individual Site Status

Recruiting

Facility Name

Research Site

City

Oslo

ZIP/Postal Code

0450

Country

Norway

Individual Site Status

Recruiting

Facility Name

Research Site

City

Tønsberg

ZIP/Postal Code

3103

Country

Norway

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ålesund

ZIP/Postal Code

6017

Country

Norway

Individual Site Status

Recruiting

Facility Name

Research Site

City

Lisboa

ZIP/Postal Code

1769-001

Country

Portugal

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Lisboa

ZIP/Postal Code

1998-018

Country

Portugal

Individual Site Status

Recruiting

Facility Name

Research Site

City

Matosinhos

ZIP/Postal Code

4454-509

Country

Portugal

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Vila Nova de Gaia

ZIP/Postal Code

4434-502

Country

Portugal

Individual Site Status

Recruiting

Facility Name

Research Site

City

Guaynabo

ZIP/Postal Code

00968

Country

Puerto Rico

Individual Site Status

Recruiting

Facility Name

Research Site

City

San Juan

ZIP/Postal Code

00921-3201

Country

Puerto Rico

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Galdakao

ZIP/Postal Code

48960

Country

Spain

Individual Site Status

Recruiting

Facility Name

Research Site

City

Madrid

ZIP/Postal Code

28040

Country

Spain

Individual Site Status

Recruiting

Facility Name

Research Site

City

Malaga

ZIP/Postal Code

29010

Country

Spain

Individual Site Status

Recruiting

Facility Name

Research Site

City

Mérida

ZIP/Postal Code

06800

Country

Spain

Individual Site Status

Recruiting

Facility Name

Research Site

City

Pozuelo de Alarcon

ZIP/Postal Code

28223

Country

Spain

Individual Site Status

Recruiting

Facility Name

Research Site

City

Santander

ZIP/Postal Code

39008

Country

Spain

Individual Site Status

Recruiting

Facility Name

Research Site

City

Valencia

ZIP/Postal Code

46010

Country

Spain

Individual Site Status

Recruiting

Facility Name

Research Site

City

Zaragoza

ZIP/Postal Code

50009

Country

Spain

Individual Site Status

Recruiting

Facility Name

Research Site

City

Göteborg

ZIP/Postal Code

413 45

Country

Sweden

Individual Site Status

Recruiting

Facility Name

Research Site

City

Göteborg

ZIP/Postal Code

413 46

Country

Sweden

Individual Site Status

Recruiting

Facility Name

Research Site

City

Lund

ZIP/Postal Code

222 22

Country

Sweden

Individual Site Status

Recruiting

Facility Name

Research Site

City

Malmö

ZIP/Postal Code

205 02

Country

Sweden

Individual Site Status

Recruiting

Facility Name

Research Site

City

Stockholm

ZIP/Postal Code

11239

Country

Sweden

Individual Site Status

Recruiting

Facility Name

Research Site

City

Örebro

ZIP/Postal Code

70185

Country

Sweden

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Ankara

ZIP/Postal Code

06620

Country

Turkey

Individual Site Status

Recruiting

Facility Name

Research Site

City

Aydin

ZIP/Postal Code

09100

Country

Turkey

Individual Site Status

Recruiting

Facility Name

Research Site

City

Istanbul

ZIP/Postal Code

34069

Country

Turkey

Individual Site Status

Recruiting

Facility Name

Research Site

City

Istanbul

ZIP/Postal Code

34098

Country

Turkey

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Izmir

ZIP/Postal Code

35040

Country

Turkey

Individual Site Status

Recruiting

Facility Name

Research Site

City

Izmir

ZIP/Postal Code

35965

Country

Turkey

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Mersin

ZIP/Postal Code

33343

Country

Turkey

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hanoi

ZIP/Postal Code

100000

Country

Vietnam

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ho Chi Minh

ZIP/Postal Code

700000

Country

Vietnam

Individual Site Status

Recruiting

12. IPD Sharing Statement

Learn more about this trial

Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations

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Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations (OBERON)

Chronic Obstructive Pulmonary Disease (COPD)

About this trial

Eligibility Criteria

Sites / Locations

Arms of the Study

Arm 1

Arm 2

Arm 3

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

1. Study Identification

2. Study Status

3. Sponsor/Collaborators

4. Oversight

5. Study Description

6. Conditions and Keywords

7. Study Design

8. Arms, Groups, and Interventions

10. Eligibility

12. IPD Sharing Statement

Learn more about this trial