Response To Medical Therapy in Inflammatory Bowel Disease Patients Carrying-out a Prescribed Exercise Programme
Inflammatory Bowel Diseases
About this trial
This is an interventional treatment trial for Inflammatory Bowel Diseases
Eligibility Criteria
Inclusion Criteria:
- 18 years of age or above.
- Confirmed moderate to severe inflammatory bowel disease based on endoscopic evaluation, clinical scoring tools and faecal calprotectin.
- Be able to provide written informed consent.
- Stable dose of steroids.
- Physically able to complete an exercise programme.
- Healthy controls.
Exclusion Criteria:
- Inability to participate in the exercise program (unable to perform 6MWT, unable to attend for assessment of parameters at any time point).
- An uncontrolled cardiovascular condition such as unstable angina, uncontrolled cardiac arrhythmias, uncontrolled symptomatic heart failure or symptomatic severe aortic stenosis.
- A significant musculoskeletal condition, neurological condition, mental illness or intellectual disability that restricts participation in a physical exercise program.
- Pregnancy.
- Healthy controls with underlying inflammatory conditions.
Sites / Locations
- Beaumont HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Other
No Intervention
Inflammatory Bowel Disease Exercise Group
Inflammatory Bowel Disease Control Group
Healthy Control Group
The exercise group will be randomized to a 20-week physician-prescribed exercise programme following the principles of Frequency, Intensity, Time, and Type (FITT) in addition to best medical therapy with the aim of increasing physical fitness levels, inflammatory response, quality of life/fatigue improvements and favorable body composition changes.
The IBD control group will be randomized to best medical therapy alone.
A group of healthy controls without inflammatory bowel disease will be included in the study for comparison of inflammatory markers including cytokine analysis and body composition.