Autologous Platelet Rich Plasma Intraovarian Infusion for Poor Responders (PRPPOR)
Poor Response to Ovulation Induction, Infertility, Female, Ovarian Insufficiency
About this trial
This is an interventional treatment trial for Poor Response to Ovulation Induction focused on measuring Autologous platelet rich plasma intraovarian infusion, Assisted reproduction, PRP, In vitro fertilization, Ovarian functionality improvement
Eligibility Criteria
Inclusion Criteria:
Poor Ovarian Response according to Bologna Criteria (fulfilling 2 out of 3 of the following):
- Age ≥ 40 years
- AMH < 1.1 ng/ml OR AFC < 7
≤ 3 oocytes with a conventional stimulation protocol
- Discontinuation of any complementary/adjuvant treatment including hormone replacement and acupuncture, for at least three months prior to recruitment.
- Willing to comply with study requirements
Exclusion Criteria:
- Any pathological disorder related to reproductive system anatomy
- Cycle irregularities
- Amenorrhea
- Endometriosis
- Adenomyosis
- Fibroids and adhesions
- Infections in reproductive system
- Current or previous diagnosis of cancer in reproductive system
- History of familiar cancer in reproductive system
- Severe male factor infertility
- Prior referral for Preimplantation Genetic Testing (PGT) -Ovarian inaccessibility -Endocrinological disorders (Hypothalamus-
- Pituitary disorders, thyroid dysfunction, diabetes mellitus, metabolic syndrome)
- BMI>30 kg/m2 or BMI<18.5 kg/m2
- Systematic autoimmune disorders
Sites / Locations
- Genesis Athens ClinicRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Experimental: Group of participants receiving PRP treatment
Control Group: Group of participants receiving standard protocol
Women presenting with POR, treated with autologous PRP intraovarian infusion during the mid-luteal phase, undergoing a subsequent stimulated fresh ET-ICSI cycle on the first month following PRP infusion
Women presenting with POR undergoing a stimulated fresh ET-ICSI cycle