Evaluation of the Effectiveness of Extracorporeal Methods for Removing Mediators of Systemic Inflammation
Renal Failure Acute, Multiple Organ Failure, Cardiovascular Diseases
About this trial
This is an interventional treatment trial for Renal Failure Acute focused on measuring mediators of systemic inflammation, extracorporeal methods, interleukins
Eligibility Criteria
Inclusion Criteria:
- multiple organ dysfunction;
- SOFA equal to or more than 4;
- CRP equal to or more than 100 ng / ml;
- increase of IL6 by 5 times or more
Exclusion Criteria:
- the impossibility to use heparin ( bleeding; heparin-induced thrombocytopenia)
Sites / Locations
- Petrovsky Nacional research Centre of SurgeryRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
oXiris
oXiris in combination with Jafron HA330
Monotoring of extracorporeal Method for Removing Mediators of Systemic Inflammation of oXiris will be performed for 24 hours
Extracorporeal Method for Removing Mediators of Systemic Inflammation oXiris in combination with Jafron HA330 will be performed for 4 hours. If SOFA is more or equally 4 , CRP is more than 100 ng/ml;, the IL6 value is increased by 5 or more times after 12 hours of procedure Jafron HA330 will be reconnected and performed for 4 hours. Monitoring of whole procedure will be performed for 24 hours.