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Interest of GLP1 Analogues in Overweight Type 2 Diabetic Patients With Chronic Inflammatory Bowel Disease (DiagMICI)

Primary Purpose

Inflammatory Bowel Diseases, Diabetes Mellitus, Type 2

Status
Recruiting
Phase
Not Applicable
Locations
France
Study Type
Interventional
Intervention
GLP1 analogues
Sponsored by
Fondation HΓ΄pital Saint-Joseph
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Inflammatory Bowel Diseases

Eligibility Criteria

18 Years - 75 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers
  • Patients between 18 and 75 years of age
  • Patients with inflammatory bowel disease (Crohn's disease (CD) or ulcerative colitis (UC))
  • Patient with poorly controlled type 2 diabetes (defined as deviation from the set glycemic target of more than 1% HbA1c)
  • Patient with a BMI β‰₯ 25 kg/m2
  • For women of childbearing age: effective contraception* during treatment and up to 5 weeks after discontinuation

    * Any contraceptive method used regularly and appropriately that has a low failure rate (i.e., less than 1% per year)

  • Patient enrolled in a health insurance plan
  • Francophone patient
  • Patient with free, informed, written consent

Exclusion Criteria:

  • Patient with a personal or family history of medullary thyroid cancer
  • Patient with an active cancer
  • Patient with a history of acute or chronic pancreatitis
  • Patients with a history of hypersensitivity to GLP1 analogues (or to any other component of the product)
  • Patient with a history of severe GI intolerance to GLP-1 receptor agonists
  • Patient already included in a risky interventional research protocol (RIPH1)
  • Pregnant or breastfeeding women
  • Patients with congestive heart failure New York Heart Association (NYHA) class IV
  • Patient with end-stage renal disease
  • Patients with clinically significant sustained elevation of resting heart rate
  • Patient with anti-GAD antibodies in a previous workup at inclusion
  • Patient under guardianship or curatorship
  • Patient under court protection
  • Patient deprived of liberty

Sites / Locations

  • Groupe Hospitalier Paris Saint-JosephRecruiting

Arms of the Study

Arm 1

Arm Type

Experimental

Arm Label

GLP1 analogues

Arm Description

This cohort study has 2 phases: an observation phase to collect all initial clinical and biological parameters and an intervention phase (prescription of GLP1 analogues) of 6 months including a visit at 3 and 6 months.

Outcomes

Primary Outcome Measures

Glycemic control
This outcome corresponds to the Change in HbA1c at 3 and 6 months compared with baseline at initiation of therapy.
Weight loss
This outcome corresponds to the weight reducation at 3 and 6 months compared to baseline.

Secondary Outcome Measures

Tolerance of GLP1 analogues after 3 months of treatment
This outcome corresponds to th number of serious and non-serious adverse events after 3 months of treatment with aGLP1.
Tolerance of GLP1 analogues after 6 months of treatment tolerance of GLP1 analogues after 3 and 6 months of treatment
This outcome corresponds to the number of serious and non-serious adverse events after 6 months of treatment with aGLP1.
Quality of life after 3 months of treatment
This outcome corresponds to the Quality of life of patients according to the Inflammatory Bowel Disease Questionnaire score. It includes 32 items in four domains: digestive symptoms (10 items), systemic symptoms (5 items), emotional disorders (12 items), social function (5 items). Each item is measured using the Likert technique. For each item, the interviewer presents a set of 7 statements describing an attitude. To each degree of agreement, a numerical value (from 1 to 7) is attached. In this way, by adding the individual scores, a total numerical value can be calculated. The total score ranges from 32 to 224, the higher the score the better the quality of life. This index has been validated and is correlated with the different disease activity scores.
Quality of life after 6 months of treatment
This outcome corresponds to the Quality of life of patients according to the Inflammatory Bowel Disease Questionnaire score. It includes 32 items in four domains: digestive symptoms (10 items), systemic symptoms (5 items), emotional disorders (12 items), social function (5 items). Each item is measured using the Likert technique. For each item, the interviewer presents a set of 7 statements describing an attitude. To each degree of agreement, a numerical value (from 1 to 7) is attached. In this way, by adding the individual scores, a total numerical value can be calculated. The total score ranges from 32 to 224, the higher the score the better the quality of life. This index has been validated and is correlated with the different disease activity scores.
Impact of aGLP1 on the treatment already in place to regulate blood glucose
This outcome corresponds to the reduction in number/dose of anti-diabetic medications or daily insulin dose.

Full Information

First Posted
December 30, 2021
Last Updated
March 6, 2023
Sponsor
Fondation HΓ΄pital Saint-Joseph
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1. Study Identification

Unique Protocol Identification Number
NCT05196958
Brief Title
Interest of GLP1 Analogues in Overweight Type 2 Diabetic Patients With Chronic Inflammatory Bowel Disease
Acronym
DiagMICI
Official Title
Interest of GLP1 Analogues (aGLP1) in Overweight Type 2 Diabetic Patients With Chronic Inflammatory Bowel Disease (IBD)
Study Type
Interventional

2. Study Status

Record Verification Date
March 2023
Overall Recruitment Status
Recruiting
Study Start Date
January 25, 2022 (Actual)
Primary Completion Date
January 14, 2024 (Anticipated)
Study Completion Date
December 31, 2024 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Fondation HΓ΄pital Saint-Joseph

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
The risk of type 2 diabetes appears to be higher in patients with chronic inflammatory diseases, including chronic inflammatory bowel disease (IBD). IBD is a group of inflammatory diseases that includes mainly Crohn's disease and ulcerative colitis. Although the majority of IBD patients are not overweight, the prevalence of obesity in this population remains significant, estimated at 15 to 40%. It has been shown that obesity can impact the response to therapies used in IBD as well as the clinical course of the disease: 1) plasma concentrations of immunomodulatory therapies are often lower in the obese compared to those with a normal Body Mass Index (BMI) with a lower dose per kg of the administered drug as well as an acceleration of drug clearance. 2nd) Surgical management of IBD is associated with a higher risk of peri- and post-operative complications in obese patients, including an increase in operating time, bleeding risk, length of hospital stay and percentage of post-operative infections. 3e) Finally, obesity seems to have a negative impact on the clinical course of IBD, with a correlation between an increase in BMI and an increase in the number of hospitalizations, the number of follow-up consultations and the need for therapeutic escalation. One of the common pathophysiological explanations between IBD and metabolic syndrome (including type 2 diabetes and obesity), would involve metabolites in the gut that are modulated by the gut microbiota. Glucagon-Like Peptide 1 (aGLP1) analogues are a new class of injectable antidiabetic drugs that have revolutionized the management of type 2 diabetes. They include exenatide, lixisenatide, liraglutide, dulaglutide and semaglutide. They combine an effect on glycemic control but also usually a weight loss. In some countries, they are used in non-diabetic obese patients, with a weight loss of up to -10 to -15%. These molecules bind to GLP1 receptors, stimulate insulin secretion when blood glucose levels are high, decrease glucagon secretion, slow gastric emptying and stimulate satiety. In addition to glycemic control, weight reduction is most often associated. In addition, some aGLP1s have been shown to reduce cardiovascular events in diabetics. They are well tolerated, but their side effects are mainly digestive, such as nausea, vomiting and sometimes diarrhea. These problems occur in about 20% of cases, most often after the first injection, with vomiting requiring permanent cessation of treatment. Most often they gradually subside, spontaneously or after symptomatic treatment, and allow titration of the drug. Due to the lack of studies and possible intestinal effects, aGLP1 is not recommended in cases of severe gastrointestinal disease, and therefore in cases of IBD, although it is not contraindicated. The main objective of this study is to test the interest of these GLP1 analogues in type 2 diabetics with IBD, who are overweight and whose glycemic target is not reached. The expected benefit is to facilitate diabetes control and weight loss in this population. The second objective is to monitor the occurrence of adverse events in this population with the different GLP1 analogues used.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Inflammatory Bowel Diseases, Diabetes Mellitus, Type 2

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
N/A
Enrollment
20 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
GLP1 analogues
Arm Type
Experimental
Arm Description
This cohort study has 2 phases: an observation phase to collect all initial clinical and biological parameters and an intervention phase (prescription of GLP1 analogues) of 6 months including a visit at 3 and 6 months.
Intervention Type
Other
Intervention Name(s)
GLP1 analogues
Intervention Description
This cohort study has 2 phases: an observation phase to collect all initial clinical and biological parameters and an intervention phase (prescription of GLP1 analogues) of 6 months including a visit at 3 and 6 months.
Primary Outcome Measure Information:
Title
Glycemic control
Description
This outcome corresponds to the Change in HbA1c at 3 and 6 months compared with baseline at initiation of therapy.
Time Frame
Month 6
Title
Weight loss
Description
This outcome corresponds to the weight reducation at 3 and 6 months compared to baseline.
Time Frame
Month 6
Secondary Outcome Measure Information:
Title
Tolerance of GLP1 analogues after 3 months of treatment
Description
This outcome corresponds to th number of serious and non-serious adverse events after 3 months of treatment with aGLP1.
Time Frame
Month 3
Title
Tolerance of GLP1 analogues after 6 months of treatment tolerance of GLP1 analogues after 3 and 6 months of treatment
Description
This outcome corresponds to the number of serious and non-serious adverse events after 6 months of treatment with aGLP1.
Time Frame
Month 6
Title
Quality of life after 3 months of treatment
Description
This outcome corresponds to the Quality of life of patients according to the Inflammatory Bowel Disease Questionnaire score. It includes 32 items in four domains: digestive symptoms (10 items), systemic symptoms (5 items), emotional disorders (12 items), social function (5 items). Each item is measured using the Likert technique. For each item, the interviewer presents a set of 7 statements describing an attitude. To each degree of agreement, a numerical value (from 1 to 7) is attached. In this way, by adding the individual scores, a total numerical value can be calculated. The total score ranges from 32 to 224, the higher the score the better the quality of life. This index has been validated and is correlated with the different disease activity scores.
Time Frame
Month 3
Title
Quality of life after 6 months of treatment
Description
This outcome corresponds to the Quality of life of patients according to the Inflammatory Bowel Disease Questionnaire score. It includes 32 items in four domains: digestive symptoms (10 items), systemic symptoms (5 items), emotional disorders (12 items), social function (5 items). Each item is measured using the Likert technique. For each item, the interviewer presents a set of 7 statements describing an attitude. To each degree of agreement, a numerical value (from 1 to 7) is attached. In this way, by adding the individual scores, a total numerical value can be calculated. The total score ranges from 32 to 224, the higher the score the better the quality of life. This index has been validated and is correlated with the different disease activity scores.
Time Frame
Month 6
Title
Impact of aGLP1 on the treatment already in place to regulate blood glucose
Description
This outcome corresponds to the reduction in number/dose of anti-diabetic medications or daily insulin dose.
Time Frame
Month 6

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
75 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Patients between 18 and 75 years of age Patients with inflammatory bowel disease (Crohn's disease (CD) or ulcerative colitis (UC)) Patient with poorly controlled type 2 diabetes (defined as deviation from the set glycemic target of more than 1% HbA1c) Patient with a BMI β‰₯ 25 kg/m2 For women of childbearing age: effective contraception* during treatment and up to 5 weeks after discontinuation * Any contraceptive method used regularly and appropriately that has a low failure rate (i.e., less than 1% per year) Patient enrolled in a health insurance plan Francophone patient Patient with free, informed, written consent Exclusion Criteria: Patient with a personal or family history of medullary thyroid cancer Patient with an active cancer Patient with a history of acute or chronic pancreatitis Patients with a history of hypersensitivity to GLP1 analogues (or to any other component of the product) Patient with a history of severe GI intolerance to GLP-1 receptor agonists Patient already included in a risky interventional research protocol (RIPH1) Pregnant or breastfeeding women Patients with congestive heart failure New York Heart Association (NYHA) class IV Patient with end-stage renal disease Patients with clinically significant sustained elevation of resting heart rate Patient with anti-GAD antibodies in a previous workup at inclusion Patient under guardianship or curatorship Patient under court protection Patient deprived of liberty
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Adela VOICAN, MD
Phone
144127608
Ext
+33
Email
avoican@ghpsj.fr
First Name & Middle Initial & Last Name or Official Title & Degree
Helene BEAUSSIER, PharmD, PhD
Phone
144127883
Ext
+33
Email
crc@ghpsj.fr
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Adela VOICAN, MD
Organizational Affiliation
Fondation HΓ΄pital Saint-Joseph
Official's Role
Principal Investigator
Facility Information:
Facility Name
Groupe Hospitalier Paris Saint-Joseph
City
Paris
ZIP/Postal Code
75014
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Helene BEAUSSIER, PharmD, PhD
Phone
144127883
Ext
+33
Email
crc@ghpsj.fr

12. IPD Sharing Statement

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Interest of GLP1 Analogues in Overweight Type 2 Diabetic Patients With Chronic Inflammatory Bowel Disease

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