Effect of Controlling Environmental Risk Factors in Established RA (DISRUPT-estRA)
Primary Purpose
Rheumatoid Arthritis
Status
Recruiting
Phase
Not Applicable
Locations
France
Study Type
Interventional
Intervention
Management of risk factors
Smoking cessation
weightloss
periodontal disease treatment
increased physical activity
Decreased anxiety
Sponsored by
About this trial
This is an interventional prevention trial for Rheumatoid Arthritis focused on measuring prevention, smoking, diet, periodontitis, physical activity, stress
Eligibility Criteria
Inclusion Criteria:
- RA (ACR / EULAR 2010 criteria), with an active disease (2.6 <DAS 28 <5.1)
- Basis treatment for at least 3 months and corticoids <= 10mg / day
And at least 3 risk factors among:
- BMI ≥25 kg / m²
- Low physical activity (IPAQ short version)
- Active smoking
- Periodontitis ( bone loss on dental panoramic)
- Anxiety ( Beck anxiety Index > 16)
Exclusion Criteria:
- Patient under protective measure or unable to consent
- Patient for whom a change in basic treatment for RA is planned within 6 months
- Active cancer
- Active infection
- Antibiotic therapy in the previous 3 months
- No health cover
- Diabetes
- Unbalanced psychiatric pathologies
- Pregnant or breastfeeding women
Sites / Locations
- Centre Hospitalier Universitaire de MontpellierRecruiting
Arms of the Study
Arm 1
Arm Type
Experimental
Arm Label
Management of risk factors
Arm Description
-6 month program for reduction /correction of risk factors in patient with active RA : Smoking cessation weightloss Increased physical activity Periodontal treatment Decreased anxiety
Outcomes
Primary Outcome Measures
Estimate the effectiveness at 6 months of this program on the overall reduction / correction of risk factors.
Number of patients for whom at least 2 or 3 risk factors (depending on whether 3 present or 4-5 present at baseline) are corrected / in the process of correction.
Risk factors will be considered corrected / in the process of being corrected if:
Weight loss ≥5% of initial weight at 6 months (objective measurement of weight) and / or BMI at 6 months < 25kg/m²
Complete smoking cessation (declarative assessment)
Correction of sedentary lifestyle with moderate to strong IPAQ AND increase of ≥2,000 steps / day compared to the initial assessment (on average 5 days / 7) (questionnaire and quantified assessment obtained with the pedometer and automatically reported on the platform)
Improvement in periodontal disease scores ≥4 points on 6 teeth assessed according to Ramfjord's recommendation (plaque index (Sillness and Loe index), gingival (Lobene index) and papillary bleeding index) (evaluation by the periodontologist)
Decrease in anxiety score from N class to N-1 class
Secondary Outcome Measures
To assess the acceptability and adherence of RA patients to the intervention program.
Acceptability:
number of patients agreeing to participate in the protocol / total number of screened patients fulfilling the inclusion criteria.
questionnaire with different visual analog scales carried out at the end of the program.
Adherence: assessed by completing online questionnaires / weight, using the accelerometer, participating in various teleconsultations and organized group sessions
At least two risk factors (if 3 present at base) or at least three (if 4 or 5 present at base) are corrected / in the process of correction.
same description as for the outcome 1
RA activity
DAS 28-CRP, RAID, biological markers (FR, ACPA, CRP)
Distribution of the different germs of the oral and fecal micobiota and alpha and beta diversity
targeted metagenomics 16s RNA
Personality traits assessed by the Minnesota Multiphasic Personality Inventory questionnaire (MMPI)
Full Information
NCT ID
NCT05198271
First Posted
January 5, 2022
Last Updated
September 7, 2023
Sponsor
University Hospital, Montpellier
1. Study Identification
Unique Protocol Identification Number
NCT05198271
Brief Title
Effect of Controlling Environmental Risk Factors in Established RA
Acronym
DISRUPT-estRA
Official Title
Effect of Controlling Environmental Risk Factors in Established RA
Study Type
Interventional
2. Study Status
Record Verification Date
September 2023
Overall Recruitment Status
Recruiting
Study Start Date
May 31, 2022 (Actual)
Primary Completion Date
July 2024 (Anticipated)
Study Completion Date
January 2025 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
University Hospital, Montpellier
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No
5. Study Description
Brief Summary
The factors contributing to the development of rheumatoid arthritis are multiple, with a role of the environment and a predisposing genetic background.
Among the modifiable environmental factors :unbalanced diet, overweight, low physical activity, smoking, periodontal disease, stress have been identified as risk factors for developing RA.
By causing low-grade inflammation and stimulation of the immune system (particularly through adipokines, citrullination phenomena and changes in the microbiota), these factors promote the onset of the disease and could also participate in the maintenance of inflammatory processes.
Thus, obese subjects have more active RA, a lower therapeutic response, and weight loss is associated with lower disease activity ; sedentary lifestyle is associated with more active RA and increased physical activity has beneficial effects on RA; people who smoke respond less well to treatment; periodontal disease is associated with more active RA and their treatment is associated with a decrease in this activity.
Finally, different methods having a beneficial impact on stress (mindfulness meditation, yoga, relaxation, etc.) have shown interesting results in patients with RA.
It is important to note that all of these factors are also associated with an increased cardiovascular risk, the leading cause of death in RA.
The combination of these factors probably has synergistic effects and it is therefore relevant to propose a correction of all these factors in the same program.
We have developed a management program for environmental risk factors for RA based with experts including rheumatologists, nutritionists, smoking cessation specialists, periodontal disease specialists and stress specialists.
Detailed Description
Methodology:
We will conduct a Phase 2 to one phase trial with A'Hern design.
The patients included will have RA (ACR / EULAR 2010 criteria), with an active disease (2.6 <DAS 28 <5.1), and at least 3 risk factors among: BMI ≥25 kg / m², low physical activity , active smoking, periodontitis and anxiety.
The primary endpoint will be the number of patients for whom at least 2 or 3 risk factors (depending on whether 3 present or 4-5 present at baseline) are corrected / in the process of being corrected at 6 months.
The secondary endpoints will be:
A) Acceptability: number of patients agreeing to participate in the protocol / total number of screened patients fulfilling the inclusion criteria; questionnaires with EVA carried out at the end of the program; Membership of the program: online completion of questionnaires, use of the accelerometer, participation in teleconsultations and organized group sessions.
B) For each risk factors: number of patients who corrected it at 3 and 6 months.
C) RA activity measured by DAS28-CRP + RAID questionnaire, biological markers
D) Distribution of the different germs of the oral and faecal micobiota and diversity.
As risks factor are established chronically, we hypothesize that only 10% of patients would correct at least 2 or 3 risk factors over 6 months in the absence of intervention. The expected efficiency is 40%.
By recruiting 25 patients, we will have a power of 90% to demonstrate that the one-sided 95% confidence interval of the effectiveness of the intervention is greater than 10% (p (0) if the true value of effectiveness is 35% (p (1)). This demonstration will be made if 6 patients out of 25 are successful.
Procedure:
3 visits will be necessary for rheumatological and biological evaluations (inclusion +/- M0, M3 and M6).
All patients will have 2 periodontal visits (M0 and M6 for evaluation and scaling). Those with periodontitis will have other visits depending on the care to be performed.
The smoking patients will have teleconsultations (TC) with a tobacco specialist (S0, S4 and S8 then according to tobacco specialist).
All patients will have a TC with a dietitian (45 min 1st consultation with set goals) and those overweight will then have a TC every 15 days for 3 months.
All patients will have a TC with a sports doctor (assessment of physical activity and development of a personalized program, explanation of the pedometer provided). For those with low physical activity, a virtual group session of 45 min / week will be organized.
Patients with anxiety will have TC with a psychiatrist specializing in stress management, with training in the use of cardiac coherence from connected equipment given to the patient.
All the interventions will be coordinated on an existing platform (MyGoodLife) which allows the dietary assessment, the automatic report of connected objects (pedometer) and the organization of group sessions.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Rheumatoid Arthritis
Keywords
prevention, smoking, diet, periodontitis, physical activity, stress
7. Study Design
Primary Purpose
Prevention
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
N/A
Enrollment
25 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Management of risk factors
Arm Type
Experimental
Arm Description
-6 month program for reduction /correction of risk factors in patient with active RA :
Smoking cessation
weightloss
Increased physical activity
Periodontal treatment
Decreased anxiety
Intervention Type
Other
Intervention Name(s)
Management of risk factors
Intervention Description
For all patients:
Online dietician consultation (45 min 1st consultation with set objectives then 15-20 min for the following ones) then proposal of varied weekly menus, adapted to different cultural and social contexts by email and reassessment at M3 and M6
Clinical and radiographic periodontological evaluation at M0 and M6 by a specialist with dental hygiene advice with delivery of equipment and scaling
Initial teleconsultation with motivational interview by sports doctor / APA (30 min) with evaluation of initial physical activity, search for contraindications and development of a personalized program with aerobic and resistance training. Provision of filmed sessions and digital exercise materials for regular practice at home and self-assessment using data from the accelerometer with automatic online report.
Motivational supports on the MyGoodLife / MyGoodCare platform (weight, food questionnaire, pedometer, tobacco consumption)
Intervention Type
Behavioral
Intervention Name(s)
Smoking cessation
Intervention Description
- For active smoking patients:
Tobacco consultations: S0, S4 and S8 then according to the opinion of the tobacco specialist
Nicotine substitutes +/- varenicline according to tobacco consumption
Online notebook to record tobacco consumption and "triggers"
Intervention Type
Behavioral
Intervention Name(s)
weightloss
Intervention Description
-For overweight or obese patients: Online dietician consultation every 15 days for 3 months, the consultation based on the online filling of food questionnaires and the weight curve
Intervention Type
Other
Intervention Name(s)
periodontal disease treatment
Intervention Description
- For patients with periodontal disease: treatment of periodontal disease (planing, cast splint, tooth avulsion, etc.) between M0 and M3, dental panoramic M0 at inclusion and M6
Intervention Type
Behavioral
Intervention Name(s)
increased physical activity
Intervention Description
- For patients with low physical activity: Follow-up by level gp session: 45 '/ week for 3 months
Intervention Type
Behavioral
Intervention Name(s)
Decreased anxiety
Intervention Description
- For anxious patients:
Teleconsultation with a psychiatrist specializing in stress management, global assessment, identification of the factors involved and training in the use of cardiac coherence
Delivery of connected equipment for the practice of cardiac coherence
Primary Outcome Measure Information:
Title
Estimate the effectiveness at 6 months of this program on the overall reduction / correction of risk factors.
Description
Number of patients for whom at least 2 or 3 risk factors (depending on whether 3 present or 4-5 present at baseline) are corrected / in the process of correction.
Risk factors will be considered corrected / in the process of being corrected if:
Weight loss ≥5% of initial weight at 6 months (objective measurement of weight) and / or BMI at 6 months < 25kg/m²
Complete smoking cessation (declarative assessment)
Correction of sedentary lifestyle with moderate to strong IPAQ AND increase of ≥2,000 steps / day compared to the initial assessment (on average 5 days / 7) (questionnaire and quantified assessment obtained with the pedometer and automatically reported on the platform)
Improvement in periodontal disease scores ≥4 points on 6 teeth assessed according to Ramfjord's recommendation (plaque index (Sillness and Loe index), gingival (Lobene index) and papillary bleeding index) (evaluation by the periodontologist)
Decrease in anxiety score from N class to N-1 class
Time Frame
6 MONTHS
Secondary Outcome Measure Information:
Title
To assess the acceptability and adherence of RA patients to the intervention program.
Description
Acceptability:
number of patients agreeing to participate in the protocol / total number of screened patients fulfilling the inclusion criteria.
questionnaire with different visual analog scales carried out at the end of the program.
Adherence: assessed by completing online questionnaires / weight, using the accelerometer, participating in various teleconsultations and organized group sessions
Time Frame
6 MONTHS
Title
At least two risk factors (if 3 present at base) or at least three (if 4 or 5 present at base) are corrected / in the process of correction.
Description
same description as for the outcome 1
Time Frame
3 MONTHS
Title
RA activity
Description
DAS 28-CRP, RAID, biological markers (FR, ACPA, CRP)
Time Frame
3 MONTHS, 6 MONTHS
Title
Distribution of the different germs of the oral and fecal micobiota and alpha and beta diversity
Description
targeted metagenomics 16s RNA
Time Frame
3 MONTHS, 6 MONTHS
Title
Personality traits assessed by the Minnesota Multiphasic Personality Inventory questionnaire (MMPI)
Time Frame
MONTH 0
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
RA (ACR / EULAR 2010 criteria), with an active disease (2.6 <DAS 28 <5.1)
Basis treatment for at least 3 months and corticoids <= 10mg / day
And at least 3 risk factors among:
BMI ≥25 kg / m²
Low physical activity (IPAQ short version)
Active smoking
Periodontitis ( bone loss on dental panoramic)
Anxiety ( Beck anxiety Index > 16)
Exclusion Criteria:
Patient under protective measure or unable to consent
Patient for whom a change in basic treatment for RA is planned within 6 months
Active cancer
Active infection
Antibiotic therapy in the previous 3 months
No health cover
Diabetes
Unbalanced psychiatric pathologies
Pregnant or breastfeeding women
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Claire DAIEN, MD
Phone
+33467337794
Email
c-daien@chu-montpellier.fr
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Claire DAIEN, MD
Organizational Affiliation
UH of Montpellier
Official's Role
Study Director
Facility Information:
Facility Name
Centre Hospitalier Universitaire de Montpellier
City
Montpellier
ZIP/Postal Code
34295
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Claire DAIEN, MD
Phone
04 67 33 77 94
Ext
+33
Email
c-daien@chu-montpellier.fr
12. IPD Sharing Statement
Plan to Share IPD
Undecided
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Effect of Controlling Environmental Risk Factors in Established RA
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