Using the Multiphase Optimization Strategy to Adapt Cognitive Processing Therapy (CPT MOST)
Stress Disorders, Post-Traumatic
About this trial
This is an interventional treatment trial for Stress Disorders, Post-Traumatic focused on measuring Stress Disorders, Post-Traumatic, Veterans, Psychotherapy
Eligibility Criteria
Inclusion Criteria:
The investigators designed the sample to be representative of Veterans with PTSD who are treated in PTSD Clinical Teams (PCTs), with minimal exclusion criteria. PCT clinicians will provide care for those with exclusionary comorbidities or preference for a medication-based approach, as per standard policies and procedures. Inclusion criteria are:
- score of 33 or above on the PCL-5
- at least 8 weeks on a stable dose for individuals who are taking psychotropic medication
- over the age of 18
Exclusion Criteria:
- active suicidality (assessed by the Columbia Suicide Severity Rating Scale with scores indicating elevated acute risk for suicide warranting hospitalization or intensive treatment)
- need for detoxification
- severe cognitive impairment that, in the judgment of the investigator, makes it unlikely that the patient can provide informed consent or adhere to the study regimen (as evidenced by confusion, inability to track discussion or answer questions, or other clear and significant indicators of cognitive impairment)
- psychosis or unmanaged bipolar disorder
- previous receipt of CPT in the past year
- current engagement in trauma-focused psychotherapy (Prolonged Exposure or Cognitive Processing Therapy)
Sites / Locations
- VA Ann Arbor Healthcare System, Ann Arbor, MIRecruiting
- Cincinnati VA Medical Center, Cincinnati, OHRecruiting
- VA Salt Lake City Health Care System, Salt Lake City, UTRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Arm 7
Arm 8
Arm 9
Arm 10
Arm 11
Arm 12
Arm 13
Arm 14
Arm 15
Arm 16
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
Core Session 1, Core Session 2, Module Choice, Final Session
Core Session 1, Core Session 2, Modified A-B-C, Final Session
Core Session 1, Core Session 2, Challenging Questions, Final Session
Core Session 1, Core Session 2, Modified A-B-C, Challenging Questions, Module Choice, Final Session
Core Session 1, Core Session 2, Problematic Patterns, Final Session
Core Session 1, Core Session 2, Modified A-B-C, Problematic Patterns, Module Choice, Final Session
Core Session 1, Core Session 2, Challenging Questions, Problematic Patterns, Module Choice, Final Session
Core Session 1, Core Session 2, Modified A-B-C, Challenging Questions, Problematic Patterns, Final Session
Core Session 1, Core Session 2, Challenging Beliefs, Final Session
Core Session 1, Core Session 2, Modified A-B-C , Challenging Beliefs, Module Choice, Final Session
Core Session 1, Core Session 2, Challenging Questions, Challenging Beliefs, Module Choice, Final Session
Core Session 1, Core Session 2, Modified A-B-C, Challenging Questions, Challenging Beliefs, Final Session
Core Session 1, Core Session 2, Problematic Patterns, Challenging Beliefs, Module Choice, Final Session
Core Session 1, Core Session 2, Modified A-B-C, Problematic Patterns, Challenging Beliefs, Final Session
Core Session 1, Core Session 2, Challenging Questions, Problematic Patterns, Challenging Beliefs, Final Session
Core Session 1, Core Session 2, Modified A-B-C, Challenging Questions, Problematic Patterns, Challenging Beliefs, Module Choice, Final Session