Accelerated Continue Theta-burst Stimulation (acTBS)Treatment for Obsessive Compulsive Disease
Obsessive-Compulsive Disorder, Accelerated Continue Theta-burst Stimulation, Transcranial Magnetic Stimulation
About this trial
This is an interventional treatment trial for Obsessive-Compulsive Disorder
Eligibility Criteria
Inclusion Criteria:
- Clinical diagnosis of obsessive-compulsive disorder
- Voluntarily participated and cooperated with the experiment.
Exclusion Criteria:
- History of significant head trauma or neurological disorders.
- Alcohol or drug abuse.
- Organic brain defects on T1 or T2 images.
- History of seizures or unexplained loss of consciousness.
- Family history of medication refractory epilepsy.
- Recent aggression or other forms of behavioral dyscontrol.
Sites / Locations
- Anhui Medical UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Active Comparator
Sham Comparator
accelerated continue theta-burst stimulation
1-HZ repetition transcranial magnetic stimulation Stimulation
accelerated continue theta-burst stimulation (sham)
Fifty intermittent TBS sessions (1800 pulses per session, 50 minute inter-session interval ) were delivered as ten daily sessions over five consecutive days at 80% resting motor threshold (RMT). The MRI data set should be collected before the first cTBS session and after the last cTBS session.
The repetition transcranial magnetic stimulation(rTMS) lasted 30 mins and delivered at 1 Hz with 1s duration, a total of 1800 pulses at 80% of the rest motor threshold (RMT) . MRI dataset should be acquired before the first rTMS session and after the last rTMS session.
Fifty intermittent TBS sessions (1800 pulses per session, 50 minute inter-session interval ) were delivered as ten daily sessions over five consecutive days at 80% resting motor threshold (RMT). The MRI data set should be collected before the first cTBS session and after the last rTMS session. No actual magnetic stimulation was applied on the head of the volunteers. MRI dataset should be acquired before the first cTBS session and after the last cTBS session.