Reinforcement of Placebo Response in Knee Osteoarthritis: A Randomised Trial
Knee Osteoarthritis
About this trial
This is an interventional treatment trial for Knee Osteoarthritis focused on measuring Illness perception, Knee osteoarthritis, Placebo, Randomized trial
Eligibility Criteria
Inclusion Criteria:
- Age ≥50 years
- A clinical diagnosis of tibiofemoral OA in the target knee according to the American College of Rheumatology
- Average knee pain in the last week during weight bearing activities of at least 4 on a 0 to 10 points scale (0=no pain; 10=worst possible pain).
Exclusion Criteria:
- Not able to speak or understand Danish
- Scheduled surgery during study participation
- History of target knee surgery within 12 months
- History of arthroplasty in the target knee
- Injection therapy in either knee within 3 months
- Current use of oral glucocorticoids
- Current use of synthetic or non-synthetic opioids
- Contraindications to intra-articular injections, such as wounds or skin rash over injection site.
- Planning to start or discontinue other treatment for knee OA in the study participation period
- Inflammatory arthritis, such as rheumatoid arthritis or psoriatic arthritis.
- Regional pain syndromes
- Generalised pain syndromes such as fibromyalgia
- Lumbar or cervical nerve root compression syndromes
- Any other condition or impairment that, in the opinion of the investigator, makes a potential participant unsuitable for participation or which obstruct participation, such as large knee joint effusion, uncontrolled diabetes, psychiatric and/or neurological disorders, or opiate dependency
Sites / Locations
- The Parker Institute, Bispebjerg-Frederiksberg Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
intervention arm
control arm
The illness perception conversation will be delivered in one session during around 15 minutes. The conversation will be based on responses to the eight item Brief illness perception questionnaire and a rating of the most relevant item made by the patient on the same day. The aim of the conversation will be to get an overview of the patient's illness perceptions concerning their knee OA and what is deemed the most maladaptive perceptions by the participant. Participants will be invited to elaborate on their thoughts concerning these perceptions.Although any maladaptive perceptions will be corrected if natural during the conversation, the conversation will not lead to any active attempts of changing illness perceptions. Rather, the conversation focusses on giving patients time and opportunity to express knee pain related perceptions and worries concerning their knee pain.
The control conversation will be delivered in one session during around 15 minutes. In order to create two similar conversational settings where the only difference is the actual content of the conversations. The conversation will be based on responses to an eight item questionnaire concerning motivation for research participation and - similar to the illnes perception conversation - a rating of the most relevant item made by the patient. The aim of the conversation will be to get an overview of the patient's motivation for research participation and let them elaborate on their thoughts concerning their motivation.